Patents by Inventor Sophia Lee

Sophia Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220357339
    Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).
    Type: Application
    Filed: March 21, 2022
    Publication date: November 10, 2022
    Inventors: Gary Lewis BLOOMGREN, Carmen BOZIC, Sophia LEE, Amy PACE, Tatiana PLAVINA, Meena SUBRAMANYAM
  • Patent number: 11280794
    Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: March 22, 2022
    Assignee: Biogen MA Inc.
    Inventors: Gary Lewis Bloomgren, Carmen Bozic, Sophia Lee, Amy Pace, Tatiana Plavina, Meena Subramanyam
  • Publication number: 20220011310
    Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).
    Type: Application
    Filed: August 3, 2021
    Publication date: January 13, 2022
    Inventors: Gary Lewis Bloomgren, Carmen Bozic, Sophia Lee, Meena Subramanyam, Tatiana Plavina
  • Publication number: 20200408776
    Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).
    Type: Application
    Filed: June 8, 2020
    Publication date: December 31, 2020
    Inventors: Gary Lewis BLOOMGREN, Carmen BOZIC, Sophia LEE, Amy PACE, Tatiana PLAVINA, Meena SUBRAMANYAM
  • Patent number: 10677803
    Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: June 9, 2020
    Assignee: Biogen MA Inc.
    Inventors: Gary Lewis Bloomgren, Carmen Bozic, Sophia Lee, Amy Pace, Tatiana Plavina, Meena Subramanyam
  • Patent number: 10461352
    Abstract: During operation of flow battery systems, the volume of one or more electrolyte solutions can change due to solvent loss processes. An electrochemical balancing cell can be used to combat volume variability. Methods for altering the volume of one or more electrolyte solutions can include: providing a first electrochemical balancing cell containing a membrane disposed between two half-cells, establishing fluid communication between a first aqueous electrolyte solution of a flow battery system and a first half-cell of the first electrochemical balancing cell, and applying a current to the first electrochemical balancing cell to change a concentration of one or more components in the first aqueous electrolyte solution. Applying the current causes water to migrate across the membrane, either to or from the first aqueous electrolyte solution, and a rate of water migration is a function of current.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: October 29, 2019
    Assignee: Lockheed Martin Energy, LLC
    Inventors: Jeremy Loretz, Kean Duffey, Sophia Lee
  • Patent number: 10388978
    Abstract: The invention concerns methods of determining the state of charge of a half-cell within a redox flow battery, the method comprising: (i) measuring the rate of change in equilibrium half-cell reduction potential of the electrolyte as charge is passed into the electrolyte solution within the cell; and (ii) correlating said rate of change in equilibrium half-cell reduction potential with the state of charge of said half-cell. Other aspects of the invention concern balancing the state of charge of a flow battery and methods of calibrating an oxidation/reduction probe.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: August 20, 2019
    Assignee: Lockheed Martin Energy, LLC
    Inventors: Adam Morris-Cohen, Kean Duffey, Peter F. Hays, Sophia Lee
  • Publication number: 20190227064
    Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).
    Type: Application
    Filed: December 5, 2018
    Publication date: July 25, 2019
    Inventors: Gary Lewis Bloomgren, Carmen Bozic, Sophia Lee, Meena Subramanyam, Tatiana Plavina
  • Publication number: 20190137511
    Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).
    Type: Application
    Filed: August 28, 2018
    Publication date: May 9, 2019
    Inventors: Gary Lewis BLOOMGREN, Carmen BOZIC, Sophia LEE, Amy PACE, Tatiana PLAVINA, Meena SUBRAMANYAM
  • Patent number: 10119976
    Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: November 6, 2018
    Assignee: Biogen MA Inc.
    Inventors: Gary Lewis Bloomgren, Carmen Bozic, Sophia Lee, Amy Pace, Tatiana Plavina, Meena Subramanyam
  • Publication number: 20180277868
    Abstract: During operation of flow battery systems, the volume of one or more electrolyte solutions can change due to solvent loss processes. An electrochemical balancing cell can be used to combat volume variability. Methods for altering the volume of one or more electrolyte solutions can include: providing a first electrochemical balancing cell containing a membrane disposed between two half-cells, establishing fluid communication between a first aqueous electrolyte solution of a flow battery system and a first half-cell of the first electrochemical balancing cell, and applying a current to the first electrochemical balancing cell to change a concentration of one or more components in the first aqueous electrolyte solution. Applying the current causes water to migrate across the membrane, either to or from the first aqueous electrolyte solution, and a rate of water migration is a function of current.
    Type: Application
    Filed: March 21, 2017
    Publication date: September 27, 2018
    Inventors: Jeremy LORETZ, Kean DUFFEY, Sophia LEE
  • Publication number: 20160254562
    Abstract: The invention concerns methods of determining the state of charge of a half-cell within a redox flow battery, the method comprising: (i) measuring the rate of change in equilibrium half-cell reduction potential of the electrolyte as charge is passed into the electrolyte solution within the cell; and (ii) correlating said rate of change in equilibrium half-cell reduction potential with the state of charge of said half-cell. Other aspects of the invention concern balancing the state of charge of a flow battery and methods of calibrating an oxidation/reduction probe.
    Type: Application
    Filed: November 6, 2014
    Publication date: September 1, 2016
    Inventors: Adam MORRIS-COHEN, Kean DUFFEY, Peter F. HAYS, Sophia LEE
  • Publication number: 20160116483
    Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).
    Type: Application
    Filed: May 27, 2014
    Publication date: April 28, 2016
    Inventors: Gary Lewis Bloomgren, Carmen Bozic, Sophia Lee, Amy Pace, Tatiana Plavina, Meena Subramanyam
  • Publication number: 20150220693
    Abstract: Methods, systems and kits to detect and/or quantify disease progression in a subject having a progressive form of MS are disclosed.
    Type: Application
    Filed: August 8, 2013
    Publication date: August 6, 2015
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Diego Cadavid, Deborah Ann Kinch, Sophia Lee, Lei Xu
  • Publication number: 20140322164
    Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).
    Type: Application
    Filed: May 31, 2012
    Publication date: October 30, 2014
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Gary L. Bloomgren, Carmen Bozic, Sophia Lee, Meena Subramanyam, Tatiana Plavina
  • Patent number: 6271592
    Abstract: The present disclosure pertains to our discovery that depositing various film layers in a particular order using a combination of Ion Metal Plasma (IMP) and traditional sputter deposition techniques with specific process conditions results in a barrier layer structure which provides excellent barrier properties and allows for metal/conductor filling of contact sizes down to 0.25 micron and smaller without junction spiking. Specifically, the film layers are deposited on a substrate in the following order: (a) a first layer of a barrier metal (M), deposited by IMP sputter deposition; (b) a second layer of an oxygen-stuffed barrier metal (MOx), an oxygen-stuffed nitride of a barrier metal (MNOx), or a combination thereof; (c) a third layer of a nitride of a barrier metal (MNx), deposited by IMP sputter deposition of the barrier metal in the presence of nitrogen; and (d) a fourth, wetting layer of a barrier metal, deposited by traditional sputter deposition.
    Type: Grant
    Filed: August 6, 1999
    Date of Patent: August 7, 2001
    Assignee: Applied Materials, Inc.
    Inventors: Edwin Kim, Michael Nam, Chris Cha, Gongda Yao, Sophia Lee, Fernand Dorleans, Gene Y. Kohara, Jianming Fu
  • Patent number: 5985759
    Abstract: The present disclosure pertains to our discovery that depositing various film layers in a particular order using a combination of Ion Metal Plasma (IMP) and traditional sputter deposition techniques with specific process conditions results in a barrier layer structure which provides excellent barrier properties and allows for metal/conductor filling of contact sizes down to 0.25 micron and smaller without junction spiking. Specifically, the film layers are deposited on a substrate in the following order: (a) a first layer of a barrier metal (M), deposited by IMP sputter deposition; (b) a second layer of an oxygen-stuffed barrier metal (MOx), an oxygen-stuffed nitride of a barrier metal (MNOx), or a combination thereof; (c) a third layer of a nitride of a barrier metal (MN.sub.x), deposited by IMP sputter deposition of the barrier metal in the presence of nitrogen; and (d) a fourth, wetting layer of a barrier metal, deposited by traditional sputter deposition.
    Type: Grant
    Filed: February 24, 1998
    Date of Patent: November 16, 1999
    Assignee: Applied Materials, Inc.
    Inventors: Edwin Kim, Michael Nam, Chris Cha, Gongda Yao, Sophia Lee, Fernand Dorleans, Gene Y. Kohara, Jianming Fu