Abstract: Systems, devices, and methods for data collection and development as well as providing user interaction policies are provided. In one embodiment, a method includes collecting contextual data for a first subset of a plurality of users. The method further includes generating a first set of contextual profiles for the first subset of the plurality of users based on the collected contextual data. Additionally, the method includes training one or more imputation models to develop the contextual data for the second subset of the plurality of users. The method also includes generating the contextual data for the second subset of the plurality of users using the one or more imputation models. Further, the method includes generating a second set of contextual profiles for the second subset of the plurality of users based on the generated contextual data for the second subset of the plurality of users.

Abstract: The present disclosure relates to methods and compounds for promoting anabolic pathways in neuronal cells leading to improved neuronal survival. In particular, the present disclosure relates to inhibiting PHD to promote glycolysis and neuronal survival in a variety of neurodegenerative conditions such as retinitis pigmentosa.

Abstract: Compound of formula I activate the insulin receptor kinase. Pharmaceutical compositions comprising the compounds, and methods of treatment of hyperglycemia and other diseases involving imbalance of glucose levels, especially for the treatment of type II diabetes, by administering these compounds to mammalian hosts, and processes for their preparation, are also described.