Patents by Inventor Sophia Tsai

Sophia Tsai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of hedgehog-mediated signaling pathway
    Patent number: 7829333
    Abstract: The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: November 9, 2010
    Assignees: The Johns Hopkins University School of Medicine, Baylor College of Medicine
    Inventors: Philip A. Beachy, Ming-Jer Tsai, Sophia Tsai, Venkatesh Krishnan, Chien-Huan Chen
  • Gene switch systems employing regulators with decreased dimerization
    Patent number: 7579326
    Abstract: Disclosed is a novel inducible expression system characterized by undetectable biological effect in the absence of an inducer, but which exhibits efficient inducibility in the presence of an inducer.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: August 25, 2009
    Assignees: Genetronics, Inc., Baylor College of Medicine
    Inventors: Ronald V Abruzzese, Vidya Mehta, Jeffrey L Nordstrom, Jason Fewell, Bert O'Malley, Sophia Tsai
  • Modulation of hedgehog-mediated signaling pathway
    Publication number: 20060211114
    Abstract: The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
    Type: Application
    Filed: May 22, 2006
    Publication date: September 21, 2006
    Inventors: Philip Beachy, Ming-Jer Tsai, Sophia Tsai, Venkatesh Krishnan, Chien-Huan Chen
  • Modulation of hedgehog-mediated signaling pathway
    Patent number: 7049090
    Abstract: The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
    Type: Grant
    Filed: October 1, 2003
    Date of Patent: May 23, 2006
    Assignees: The Johns Hopkins University School of Medicine, Baylor College of Medicine
    Inventors: Philip A. Beachy, Ming-Jer Tsai, Sophia Tsai, Venkatesh Krishnan, Chien-Huan Chen
  • Adenoviral vector-mediated delivery of modified steroid hormone receptors and related products and methods
    Publication number: 20050196751
    Abstract: The present invention relates to adenoviral delivery of modified steroid hormone receptor proteins. The adenoviral vector preferably contains no viral coding sequence and is capable of accepting a large insert. Such vectors preferably are capable of achieving high levels and durations of delivery and expression. The modified protein preferably is capable of distinguishing a hormone agonist from an antagonist and may be modified in the ligand binding domain, the DNA binding domain, and/or the transregulatory domain.
    Type: Application
    Filed: May 18, 2001
    Publication date: September 8, 2005
    Inventors: Mark Burcin, Bert O'Malley, Gudrun Schiedner, Sophia Tsai, Stefan Kochanek
  • Method for identifying an agent that affects a hedgehog signaling pathway
    Patent number: 6733971
    Abstract: The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: May 11, 2004
    Assignees: Baylor College of Medicine, The Johns Hopkins University School of Medicine
    Inventors: Philip A. Beachy, Ming-Jer Tsai, Sophia Tsai, Venkatesh Krishnan, Chien-Huan Chen
  • Modulation of hedgehog-mediated signaling pathway
    Publication number: 20040082036
    Abstract: The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
    Type: Application
    Filed: October 1, 2003
    Publication date: April 29, 2004
    Applicants: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE, BAYLOR COLLEGE OF MEDICINE
    Inventors: Philip A. Beachy, Ming-Jer Tsai, Sophia Tsai, Venkatesh Krishnan, Chien-Huan Chen
  • Method for identifying a hedgehog-mediated phophorylation state dependent transcription factor
    Publication number: 20020102646
    Abstract: The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
    Type: Application
    Filed: August 21, 2001
    Publication date: August 1, 2002
    Applicant: Baylor College of Medicine
    Inventors: Philip A. Beachy, Ming-Jer Tsai, Sophia Tsai, Venkatesh Krishnan, Chien-Huan Chen