Abstract: A system for real-time sinkhole detection comprises a plurality of measuring devices, a network system, and an analysis system. The plurality of measuring devices include a plurality of sensors, wherein each of the plurality sensors is configured to record, process and compile spatial data into a data set. The network system is configured to electronically collect a plurality of the data sets from each of the plurality of sensors. The analysis system comprises an electronic database system and a server. The server is configured to electronically transmit the plurality of the data sets to the electronic database system; query the data set from the electronic database system; process the data set by applying a machine learning algorithm to generate a real-time result about sinkhole detection; transmit the real-time result to an interface system; and update the electronic database system by transmitting the real-time result back to the electronic database system.

Abstract: A pericardium puncture needle assembly includes a puncture needle and a guide wire capable of sliding in the puncture needle; or includes an outer sleeve and a guide wire capable of sliding in the outer sleeve; or includes an outer sleeve and a puncture needle and a guide wire capable of sliding in the outer sleeve, wherein after the puncture needle is pulled out of the outer sleeve, the guide wire is capable of sliding in the outer sleeve. The guide wire is made of a highly elastic material and includes a far-end bent segment. The far-end bent segment is formed by bending the guide wire and has a preset bending shape, and is suitable for being recovered from a stretching state to the preset bending shape. The tip of the far-end bent segment has a pointed structure.

Abstract: A pericardium puncture needle assembly comprises a puncture needle (12) and a guide wire (13) capable of sliding in the puncture needle (12); or comprises an outer sleeve (22) and a guide wire (13) capable of sliding in the outer sleeve (22); or comprises an outer sleeve (22) and a puncture needle (12) and a guide wire (13) capable of sliding in the outer sleeve (22), wherein after the puncture needle (12) is pulled out of the outer sleeve (22), the guide wire (13) is capable of sliding in the outer sleeve (22). The guide wire (13) is made of a highly elastic material and comprises a far-end bent segment (32). The far-end bent segment (32) is formed by bending the guide wire (13) and has a preset bending shape, and is suitable for being recovered from a stretching state to the preset bending shape. The tip of the far-end bent segment has a pointed structure.

Abstract: Disclosed is a pericardiocentesis needle component (10), comprising a guide wire (13) and a puncture needle (12). The guide wire (13) extends into and through the puncture needle (12), and the guide wire (13) comprises a bent section (32) at the distal end and a straight section at the proximal end. The bent section (32) at the distal end is formed by bending the guide wire (13), and the end of the bent section is a pointed-shape structure. The guide wire (13) is made of a highly elastic material. The pointed end rotates at least 90 degrees within a range of no more than 3 mm starting from the pointed end at the bent section (32) of the guide wire. The pericardiocentesis needle component (10) of the present disclosure is less likely to damage a heart during a pericardiocentesis procedure.

Abstract: Disclosed is a pericardiocentesis needle component (10), comprising a guide wire (13) and a puncture needle (12). The guide wire (13) extends into and through the puncture needle (12), and the guide wire (13) comprises a bent section (32) at the distal end and a straight section at the proximal end. The bent section (32) at the distal end is formed by bending the guide wire (13), and the end of the bent section is a pointed-shape structure. The guide wire (13) is made of a highly elastic material. The pointed end rotates at least 90 degrees within a range of no more than 3 mm starting from the pointed end at the bent section (32) of the guide wire. The pericardiocentesis needle component (10) of the present invention is less likely to damage a heart during a pericardiocentesis procedure.

Abstract: A pericardium puncture needle assembly comprises a puncture needle (12) and a guide wire (13) capable of sliding in the puncture needle (12); or comprises an outer sleeve (22) and a guide wire (13) capable of sliding in the outer sleeve (22); or comprises an outer sleeve (22) and a puncture needle (12) and a guide wire (13) capable of sliding in the outer sleeve (22), wherein after the puncture needle (12) is pulled out of the outer sleeve (22), the guide wire (13) is capable of sliding in the outer sleeve (22). The guide wire (13) is made of a highly elastic material and comprises a far-end bent segment (32). The far-end bent segment (32) is formed by bending the guide wire (13) and has a preset bending shape, and is suitable for being recovered from a stretching state to the preset bending shape. The tip of the far-end bent segment has a pointed structure.

Abstract: A method of determining overlay error. The method includes transferring a pattern from a reticle to a wafer and selecting a first set of data points to measure the positional difference between features on the reticle and features on the wafer. The method also includes determining a second set of data points characteristic of the first set of data points but containing fewer data points. A control system for using the second set of data points to dynamically adjust the position of the reticle.

Abstract: The present invention discloses an ablation electrode used in a catheter. The ablation electrode includes an electrode shell, an optional cavity inside the electrode shell and a temperature sensor. An outflow liquid pathway for the perfusion liquid is arranged on the electrode shell, and an inflow liquid pathway for the perfusion liquid is arranged in the proximal end of the electrode shell. A thermal conduction isolation structure is arranged between the temperature sensor and the liquid pathway. The thickness of the electrode shell where the temperature sensor is located is less than 0.2 mm. The present invention also provides a perfusion electrode catheter which includes the ablation electrode. The perfused electrode catheter of the present invention can provide efficient prompts on the rising ablation temperature in the ablation process.

Abstract: A method and device for pattern alignment are disclosed. The device can include an exposure field; a die within the exposure field, wherein the die comprises an integrated circuit region, a seal ring region, and a corner stress relief region; and a die alignment mark disposed between the seal ring region and the corner stress relief region.

Abstract: Disclosed is a pericardiocentesis needle component (10), comprising a guide wire (13) and a puncture needle (12). The guide wire (13) extends into and through the puncture needle (12), and the guide wire (13) comprises a bent section (32) at the distal end and a straight section at the proximal end. The bent section (32) at the distal end is formed by bending the guide wire (13), and the end of the bent section is a pointed-shape structure. The guide wire (13) is made of a highly elastic material. The pointed end rotates at least 90 degrees within a range of no more than 3 mm starting from the pointed end at the bent section (32) of the guide wire. The pericardiocentesis needle component (10) of the present invention is less likely to damage a heart during a pericardiocentesis procedure.

Abstract: A method of determining overlay error. The method includes transferring a pattern from a reticle to a wafer and selecting a first set of data points to measure the positional difference between features on the reticle and features on the wafer. The method also includes determining a second set of data points characteristic of the first set of data points but containing fewer data points. A control system for using the second set of data points to dynamically adjust the position of the reticle.

Abstract: The present disclosure provides an integrated circuit. The integrated circuit includes a semiconductor substrate; a plurality of material layers formed on the semiconductor substrate, each of the material layers including a circuit pattern therein; and a plurality of diffraction-based periodic marks formed in the plurality of material layers and stacked in a same region. One of the diffraction-based periodic marks is different from at least one other of the diffraction-based periodic marks in pitch.

Abstract: Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.

Abstract: A method and device for pattern alignment are disclosed. The device can include an exposure field; a die within the exposure field, wherein the die comprises an integrated circuit region, a seal ring region, and a corner stress relief region; and a die alignment mark disposed between the seal ring region and the corner stress relief region.

Abstract: The present disclosure provides an integrated circuit. The integrated circuit includes a semiconductor substrate; a plurality of material layers formed on the semiconductor substrate, each of the material layers including a circuit pattern therein; and a plurality of diffraction-based periodic marks formed in the plurality of material layers and stacked in a same region. One of the diffraction-based periodic marks is different from at least one other of the diffraction-based periodic marks in pitch.

Abstract: A semiconductor wafer has a pre-alignment pattern including two or more notches on the wafer edge and the notches are used for wafer pre-alignment in fabrication processes. In one embodiment, at least two distances along the wafer edge between any adjacent notches are different. In another embodiment, distances along the wafer edge between any adjacent notches are each different. In another aspect, the pre-alignment pattern includes one or more notches on the wafer edge and one flat side on the wafer edge, wherein the notches and the flat side are used for wafer pre-alignment in fabrication processes. In one embodiment, at least two distances along the wafer edge between any adjacent notches or between the flat side and an adjacent notch are different. In another embodiment, distances along the wafer edge between any adjacent notches and between the flat side and an adjacent notch are each different.

Abstract: Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.

Abstract: Methods and devices for delivering cardiac therapy to a patient are provided. Various implantable device embodiments comprise a plurality of leads and a controller. The leads include at least one lead to be positioned within a lead path to deliver ventricular pacing pulses and to deliver neural stimulation at a site proximate to the heart to inhibit sympathetic nerve activity. The controller controls delivery of the ventricular pacing pulses in accordance with a programmed pacing mode and controls delivery of the neural stimulation. The controller is programmed to deliver remodeling control therapy (RCT) by delivering ventricular pacing to pre-excite a ventricular myocardium region to mechanically unload that region during systole, and further is programmed to deliver anti-remodeling therapy (ART) by delivering neural stimulation to inhibit sympathetic nerve activity in conjunction with RCT. Other embodiments are provided herein.

Abstract: An implantable medical device for generating a cardiac pressure-volume loop, the implantable medical device comprising a pulse generator including control circuitry, a first cardiac lead including a proximal end and a distal end and coupled to the pulse generator at the proximal end, a first electrode located at the distal end of the cardiac lead and operatively coupled to the control circuitry, a sound sensor operatively coupled to the control circuitry, and a pressure sensor operatively coupled to the control circuitry, wherein the implantable medical device is adapted for measuring intracardiac impedance. A method of using the implantable medical device to optimize therapy delivered to the heart.

Abstract: An implantable medical device for generating a cardiac pressure-volume loop, the implantable medical device comprising a pulse generator including control circuitry, a first cardiac lead including a proximal end and a distal end and coupled to the pulse generator at the proximal end, a first electrode located at the distal end of the cardiac lead and operatively coupled to the control circuitry, a sound sensor operatively coupled to the control circuitry, and a pressure sensor operatively coupled to the control circuitry, wherein the implantable medical device is adapted for measuring intracardiac impedance. A method of using the implantable medical device to optimize therapy delivered to the heart.