Patents by Inventor Sophia Y. Tsai

Sophia Y. Tsai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System for regulation of transgene expression
    Publication number: 20030220286
    Abstract: Disclosed is a novel inducible expression system characterized by undetectable biological effect in the absence of an inducer, but which exhibits efficient inducibility in the presence of an inducer.
    Type: Application
    Filed: March 25, 2003
    Publication date: November 27, 2003
    Inventors: Ronald V. Abruzzese, Vidya Mehta, Jeffrey L. Nordstrom, Jason Fewell, Bert W. O'Malley, Sophia Y. Tsai
  • Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy
    Publication number: 20030109683
    Abstract: The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors. The invention further provides a molecular switch protein for regulating expression in gene therapy.
    Type: Application
    Filed: April 16, 2002
    Publication date: June 12, 2003
    Applicants: Baylor College of Medicine, Valentis, Inc.
    Inventors: Bert W. O'Malley, Ming-Jer Tsai, Sophia Y. Tsai, Harry C. Ledebur, Yaolin Wang, Joseph D. Kittle
  • Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy
    Publication number: 20020182698
    Abstract: The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors. The invention further provides a molecular switch protein for regulating expression in gene therapy.
    Type: Application
    Filed: April 16, 2002
    Publication date: December 5, 2002
    Applicant: Baylor College of Medicine
    Inventors: Bert W. O'Malley, Ming-Jer Tsai, Sophia Y. Tsai, Harry C. Ledebur, Yaolin Wang, Joseph D. Kittle
  • Modified steroid hormones for gene therapy and methods for their use
    Publication number: 20020147327
    Abstract: The present invention provides modified proteins of steroid hormone receptors. These mutated proteins are useful as gene medicines. In particular, these mutated proteins are useful for regulating expression of genes in gene therapy. In addition, the present invention provides plasmids encoding for the desired mutated steroid hormone receptor proteins, as well as cells transfected with those plasmids.
    Type: Application
    Filed: July 25, 2001
    Publication date: October 10, 2002
    Inventors: Bert W. O'Malley, Ming-Jer Tsai, Sophia Y. Tsai, Harry C. Ledebur, Yaolin Wang, Joseph D. Kittle
  • Steroid receptor coactivator compositions and methods of use
    Patent number: 6380373
    Abstract: The present invention relates to SRC-1 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for enhancing and inhibiting transcription by providing SRC-1 polypeptides or fragments thereof to a cell.
    Type: Grant
    Filed: August 21, 1996
    Date of Patent: April 30, 2002
    Assignee: Baylor College of Medicine
    Inventors: Bert O'Malley, Ming-Jer Tsai, Sophia Y. Tsai, Sergio Onate
  • Method for identifying a hedgehog-mediated phosphorylation state dependent transcription factor
    Patent number: 6277566
    Abstract: The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: August 21, 2001
    Inventors: Phillip A. Beachy, Ming-Jer Tsai, Sophia Y. Tsai, Venkatesh Krishnan, Chen-Huan Chen