Patents by Inventor Sophie Paquerault

Sophie Paquerault has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fitting melting curve data to determine copy number variation
    Patent number: 11332781
    Abstract: The present invention relates to a method and system for determining Copy Number Variations (CNVs) in a genomic test sample including target amplicons and a reference amplicons. Specifically, nucleic acid melting curves are generated for the test sample. A mathematical model is fitted to each of the nucleic acid melting curves to separate target and reference melting reactions within the measured nucleic acid melting curve. The fitting parameters of the mathematical model are calculated. A CNV of the test sample is determined based on the fitting parameters of the mathematical model corresponding to the target and reference melting reactions.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: May 17, 2022
    Assignee: Canon U.S.A., Inc.
    Inventors: Yang Yang, Sophie Paquerault, Bradley Scott Denney, Lingxia Jiang
  • System and method for modeling and subtracting background signals from a melt curve
    Patent number: 11232851
    Abstract: The present invention relates to methods for the analysis of nucleic acids present in biological samples, and more specifically to normalize a high resolution melt curve to assist in the identification of one or more properties of the nucleic acids. The present invention provides methods and systems that incorporate a background identification algorithm according to invention principles using raw melt curve data to identify reactions that are unrelated actual DNA melt reactions. Furthermore, a web-based application for analyzing experimental data is provided. The raw experimental data obtained from a variety of instruments is processed and analyzed on a server and presented to a user through a user interface (UI).
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: January 25, 2022
    Assignee: Canon Information and Imaging Solutions, Inc.
    Inventors: Yang Yang, Sophie Paquerault, Bradley Scott Denney, Lance Charlton, Jeanette Paek, Attaullah Seikh, Vyshnnavi Parthasarathy, Ken Pearson, Hung Huang, Tejinder Uppal
  • SYSTEM AND METHOD FOR COPY NUMBER VARIATION ANALYSIS
    Publication number: 20180073070
    Abstract: The present invention relates to a method and system for determining Copy Number Variations (CNVs) in a genomic test sample including target amplicons and a reference amplicons. Specifically, nucleic acid melting curves are generated for the test sample. A mathematical model is fitted to each of the nucleic acid melting curves to separate target and reference melting reactions within the measured nucleic acid melting curve. The fitting parameters of the mathematical model are calculated. A CNV of the test sample is determined based on the fitting parameters of the mathematical model corresponding to the target and reference melting reactions.
    Type: Application
    Filed: October 3, 2017
    Publication date: March 15, 2018
    Inventors: Yang Yang, Sophie Paquerault, Bradley Scott Denney, Lingxia Jiang
  • SYSTEM AND METHOD FOR MELTING CURVE NORMALIZATION
    Publication number: 20170372002
    Abstract: The present invention relates to methods for the analysis of nucleic acids present in biological samples, and more specifically to normalize a high resolution melt curve to assist in the identification of one or more properties of the nucleic acids. The present invention provides methods and systems that incorporate a background identification algorithm according to invention principles using raw melt curve data to identify reactions that are unrelated actual DNA melt reactions. Furthermore, a web-based application for analyzing experimental data is provided. The raw experimental data obtained from a variety of instruments is processed and analyzed on a server and presented to a user through a user interface (UI).
    Type: Application
    Filed: June 23, 2017
    Publication date: December 28, 2017
    Inventors: Yang Yang, Sophie Paquerault, Bradley Scott Denney, Lance Charlton, Jeanette Paek, Attaullah Seikh, Vyshnnavi Parthasarathy, Ken Pearson, Hung Huang, Tejinder Uppal