Abstract: The present invention relates to a FUBPI inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of FUBPI inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to nucleic acid molecules, such as oligonucleotides including siRNA, shRNA and antisense oligonucleotides, which are complementary to FUBPI and capable of reducing a FUBPI mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection.

Abstract: The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD109B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome.

Abstract: An endoscope including a handle and an insertion cord. The handle includes a Y-connector having: a first branch/socket having a first opening from which a first channel extends; a second branch/socket having a second opening from which a second channel extends; and a third branch/socket having a third opening, wherein the first channel and the second channel join each other in a third joined channel and the third joined channel extends inside the third branch or socket towards the third opening. The first channel and the third joined channel form together an instrument insertion channel of the Y-connector. The first channel is a curved channel having a curvature at least in sections inside the first branch or socket and/or the third joined channel is a curved channel having a curvature at least in sections inside the third branch or socket.

Abstract: A hydraulic steering arrangement (1) comprising a supply port arrangement having a pressure port and a tank port, a working port arrangement having two working ports (L, R), a mechanical steering unit (3) connected to a steering wheel (2) and being arranged between the supply port arrangement and the working port arrangement (L, R), supply valve means (12) having a connection to the pressure port and to the working port arrangement (L, R) and being controlled by a controller (10), and a steering wheel sensor (9) connected to the controller (10) is described. Such a steering arrangement could allow a comfortable feeling for the driver.

Abstract: A hydraulic steering arrangement (1) is described comprising a supply port arrangement having a pressure port (P) and tank port (T), a working port arrangement having two working ports (L, R), a steering unit (2) arranged between the supply port arrangement and the working port arrangement and a steering valve (3) arranged between the supply port arrangement and the working port arrangement. Such a steering arrangement should have a safety means. To this end in a manual steering mode the steering valve (3) is connected to the working port arrangement through the steering unit (2).

Abstract: The present disclosure provides a hearing protection system and a method for estimating a voice signal of a hearing protection system user. The hearing protection system comprises an ear canal microphone for provision of an ear canal input signal; a receiver for provision of an audio output signal; a compensation module for receiving and filtering the ear canal output signal for provision of a compensation signal; and a mixer connected to the ear canal microphone and the compensation module for provision of a voice signal, wherein the compensation module comprises a filter controller, a primary filter and a secondary filter, wherein the primary filter is a static filter, wherein primary filter coefficients of the primary filter are static, and wherein the secondary filter is an adaptive filter, wherein secondary filter coefficients of the secondary filter are controlled by the filter controller based on the voice signal.

Abstract: A communication device includes a processor; a radio interface for connection to a radio unit; and an output interface; wherein the processor is configured to: obtain a first position signal indicative of first position of a first source; obtain a user position signal indicative of position of the user; obtain a direction signal indicative of a head direction of the user; determine a first angle between the head direction and a first direction from the user to the first source; determine a first filter function based on the first angle; apply the first filter function to a first audio signal for provision of a first left output signal and a first right output signal; and output a left signal and a right signal, wherein the left signal is based on the first left output signal, and wherein the right signal is based on the first right output signal.

Abstract: A hydraulic steering arrangement (1) comprising a supply port arrangement having a pressure port and a tank port, a working port arrangement having two working ports (L, R), a mechanical steering unit (3) connected to a steering wheel (2) and being arranged between the supply port arrangement and the working port arrangement (L, R), supply valve means (12) having a connection to the pressure port and to the working port arrangement (L, R) and being controlled by a controller (10), and a steering wheel sensor (9) connected to the controller (10) is described. Such a steering arrangement could allow a comfortable feeling for the driver.

Abstract: The present disclosure provides a hearing protection system and a method for estimating a voice signal of a hearing protection system user. The hearing protection system comprises an ear canal microphone for provision of an ear canal input signal; a receiver for provision of an audio output signal; a compensation module for receiving and filtering the ear canal output signal for provision of a compensation signal; and a mixer connected to the ear canal microphone and the compensation module for provision of a voice signal, wherein the compensation module comprises a filter controller, a primary filter and a secondary filter, wherein the primary filter is a static filter, wherein primary filter coefficients of the primary filter are static, and wherein the secondary filter is an adaptive filter, wherein secondary filter coefficients of the secondary filter are controlled by the filter controller based on the voice signal.

Abstract: The present disclosure provides a hearing protection system and a method for estimating a voice signal of a hearing protection system user. The hearing protection system comprises an ear canal microphone for provision of an ear canal input signal; a receiver for provision of an audio output signal; a compensation module for receiving and filtering the ear canal output signal for provision of a compensation signal; and a mixer connected to the ear canal microphone and the compensation module for provision of a voice signal, wherein the compensation module comprises a filter controller, a primary filter and a secondary filter, wherein the primary filter is a static filter, wherein primary filter coefficients of the primary filter are static, and wherein the secondary filter is an adaptive filter, wherein secondary filter coefficients of the secondary filter are controlled by the filter controller based on the voice signal.

Abstract: A hydraulic steering arrangement (1) is described comprising a supply port arrangement having a pressure port (P) and tank port (T), a working port arrangement having two working ports (L, R), a steering unit (2) arranged between the supply port arrangement and the working port arrangement and a steering valve (3) arranged between the supply port arrangement and the working port arrangement. Such a steering arrangement should have a safety means. To this end in a manual steering mode the steering valve (3) is connected to the working port arrangement through the steering unit (2).

Abstract: The present disclosure provides a hearing protection system and a method for estimating a voice signal of a hearing protection system user.

Abstract: A conveyor belt comprising a plurality of modules hingedly connected together includes a first type of module including raised ribs arranged in columns and a second type of module including chock segments aligned with the columns. A transfer device includes fingers aligned with gaps between the chock segments and valleys between the columns. Each chock segment is substantially triangular in shape.

Abstract: A conveyor belt comprising a plurality of modules hingedly connected together includes a first type of module including raised ribs arranged in columns and a second type of module including chock segments aligned with the columns. A transfer device includes fingers aligned with gaps between the chock segments and valleys between the columns. Each chock segment is substantially triangular in shape.

Abstract: Disclosed are a method, non-transitory medium, and system of a tunable design of an Interlaken region of an integrated circuit (IC). In one embodiment, a method comprises modeling a design abstraction of an Interlaken sub-circuit of an integrated circuit as a register transfer level (RTL) code within a data processing device, wherein a first stage of sequential logic in the RTL code is associated with a first stage of combinational logic in the RTL code. The method further comprises implementing, through a processor and based on a timing parameter input into a synthesis tool associated with the RTL code, a selective bypass or a selective enablement of the first stage of sequential logic. Still further, the method comprises synthesizing, through the processor, a netlist from the RTL code, wherein the first stage of sequential logic is sequentially bypassed or sequentially enabled.

Abstract: Disclosed are a method, non-transitory medium, and system of a tunable design of an Ethernet region of an integrated circuit (IC). In one embodiment, a method comprises modeling a design abstraction of an Ethernet sub-circuit of an integrated circuit as a register transfer level (RTL) code within a data processing device, wherein a first stage of sequential logic in the RTL code is associated with a first stage of combinational logic in the RTL code. The method further comprises implementing, through a processor and based on a timing parameter input into a synthesis tool associated with the RTL code, a selective bypass or a selective enablement of the first stage of sequential logic. Still further, the method comprises synthesizing, through the processor, a netlist from the RTL code, wherein the first stage of sequential logic is sequentially bypassed or sequentially enabled.

Abstract: The present invention relates to a method of adapting signal processing characteristics of a portable communication device to a hearing impaired user, comprising the steps of determining a perceptual reference level (PRL) of a first stimuli signal (FSS) in a reference frequency band (RFB) by presenting said first stimuli signal (FSS) to said hearing impaired user, and obtaining perceptual judgements of a loudness of said first stimuli signal (FSS) from said hearing impaired user, and determining said perceptual reference level (PRL) of a second stimuli signal (SSS) in a further frequency band (FFB) by presenting said second stimuli signal (SSS) to said hearing impaired user, and requesting said hearing impaired user to compare a loudness of said second stimuli signal (SSS) with said loudness of said first stimuli signal (FSS).

Abstract: The invention relates to a device for damping the pitching of an engine-driven vehicle with a chassis and axles 5, at least one of which is mounted fixedly on the chassis. The aim of the invention is to provide a simplified corresponding device. To this end, the torque of at least one wheel borne on the axles (5) is influenced on the basis of the size of the pitching in such a way that the pitching. is damped.

Abstract: The invention relates to a device for damping the pitching of an engine-driven vehicle with a chassis and axles 5, at least one of which is mounted fixedly on the chassis. The aim of the invention is to provide a simplified corresponding device. To this end, the torque of at least one wheel borne on the axles (5) is influenced on the basis of the size of the pitching in such a way that the pitching is damped.