Abstract: A hearing aid comprises a microphone for transforming an acoustic signal surrounding a hearing aid user into an electrical signal, a signal processing means for processing the electrical signal into an electrical output signal and to a receiver (2) driven by the electrical output signal and generating an acoustical signal into the ear canal (11) of a hearing aid user. The hearing aid comprises an ear plug part (1) prepared for being arranged in the ear canal of a hearing aid user. The hearing aid comprises sound generation means for generating an acoustic guiding signal to be provided for a limited period through said receiver during insertion of the ear plug part into the ear canal, in order to be applied by the hearing aid user to optimize the positioning of the ear plug part (1). The invention further provides a method for guiding a hearing aid user during insertion of an ear plug.

Abstract: The present disclosure relates to antibodies specific for pyroglutamated A?, as well as their use in the treatment of Alzheimer's disease and as use in diagnostic methods or as diagnostic imaging ligands Further, is provided pyroglutamated N-terminal fragments of murine or human A? to generate antibodies and for use m therapeutic purposes

Abstract: A navigation system includes a hearing device configured to be head worn and having loudspeakers for emission of sound towards ears of a user; a GPS unit for determining a geographical position of the system; a sound generator connected for outputting audio signals to the loudspeakers; and a processor configured for selecting Points-Of-Interest in a vicinity of the system, and controlling the sound generator to output the audio signals that represents spoken information on the selected Points-Of-Interest in sequence.

Abstract: A hearing aid comprises a microphone for transforming an acoustic signal surrounding a hearing aid user into an electrical signal, a signal processing means for processing the electrical signal into an electrical output signal and to a receiver (2) driven by the electrical output signal and generating an acoustical signal into the ear canal (11) of a hearing aid user. The hearing aid comprises an ear plug part (1) prepared for being arranged in the ear canal of a hearing aid user. The hearing aid comprises sound generation means for generating an acoustic guiding signal to be provided for a limited period through said receiver during insertion of the ear plug part into the ear canal, in order to be applied by the hearing aid user to optimize the positioning of the ear plug part (1). The invention further provides a method for guiding a hearing aid user during insertion of an ear plug.

Abstract: A hearing aid (1) comprising a receiver (2) and at least one first microphone for transforming an acoustic signal surrounding a hearing aid user into an electrical signal, where the hearing aid comprises an ear plug part prepared for fitting tightly into the car canal (11) of a hearing aid user such that an inner volume is formed in the inner part of the ear canal between the car plug part and the car drum of the hearing aid user. The car plug part comprises a second microphone (3) arranged for transforming an acoustic signal in the volume into an electrical signal. The hearing aid comprises estimating means for estimating the effective size of the air leak between the inner volume and the surroundings based on the acoustical signal detected in said volume by said second microphone (3) from a known acoustical signal below 1000 Hz generated by the receiver. The hearing aid further comprises notification means for notifying the hearing aid user if the size range of the air leak is outside a predefined range.

Abstract: A navigation system includes: a hearing device configured to be head worn and having loudspeakers for emission of sound towards ears of a user, and accommodating an inertial measurement unit for determining head yaw, when the user wears the hearing device in its intended operational position on the user's head; a GPS unit for determining a geographical position of the system; a sound generator connected for outputting audio signals to the loudspeakers; and a processor configured for: selecting a POI in a forward looking direction of the user based on the determined head yaw, and controlling the sound generator to output the audio signals that represent spoken information on the selected POI.

Abstract: A navigation system includes a hearing device configured to be head worn and having loudspeakers for emission of sound towards ears of a user; a GPS unit for determining a geographical position of the system; a sound generator connected for outputting audio signals to the loudspeakers; and a processor configured for selecting Points-Of-Interest in a vicinity of the system, and controlling the sound generator to output the audio signals that represents spoken information on the selected Points-Of-Interest in sequence.

Abstract: A personal navigation system includes a hearing device configured to be head worn and having speakers for emission of sound towards ears of a user, the hearing device accommodating an inertial measurement unit for determining head yaw of the user, when the user wears the hearing device in its intended operational position on the user's head. The system also includes a GPS unit for determining a geographical position of the user, a sound generator connected for outputting audio signals to the speakers, and a pair of filters with a Head-Related Transfer Function connected in parallel between the sound generator and the speakers for generation of a binaural acoustic sound signal, wherein the speakers are configured to emit the sound towards the ears of the user so that the sound is perceived by the user as coming from a sound source positioned in a direction corresponding to the Head-Related Transfer Function.

Abstract: A new hearing device is provided with an inertial measurement unit for determination of yaw of the orientation of a user's head, when the hearing device is worn in its intended operational position on the user's head.

Abstract: The present invention discloses a method for production of novel carbamylated erythropoietin and compositions comprising the novel carbamylated erythropoietin and pharmaceutical compositions comprising this and uses thereof.

Abstract: The invention relates to a method for the production of a composition comprising a plurality of spherical radiofrequency-identifiable (RF-tagged) polymeric beads as well the composition as such. The invention also relates to an apparatus for analyzing, identifying or sorting as well as treating a plurality of spherical radiofrequency-identifiable beads, and further to a method for recording individual reaction steps involved in the step-wise synthesis of a chemical compound on a radiofrequency-detectable bead. The beads of the composition are substantial spherical and preferably comprises a hydrophilic polymer material so as to prevent fouling.

Abstract: The invention provides sequence information of a microbial protein having lipoxy-genase activity and a method of producing the protein by recombinant DNA technology. More specifically, the inventors have isolated a gene encoding a lipoxygenase from Gaeu-mannomyces graminis, cloned it into an E. coli strain and sequenced it. A comparison shows less than 25% identity to known lipoxygenase sequences, the closest being human 15S li-poxygenase. The inventors have expressed the lipoxygenase recombinantly and found that the recombinant lipoxygenase is glycosylated.

Abstract: The present invention relates to an apparatus and a method for converting power from a power input to a DC output current or voltage, where a first feedback circuit a traditional feedback. The converter type is a resonant DC-DC converter. The scope of the invention is to reach a high effective and fast responding switch mode power supply. This can be achieved with an apparatus or method comprising a second feedback circuit leading a signal from a serial resonance capacitor(s) to a reference input terminal at the control circuit, which second feedback circuit contains a signal depending on the actual change in charge of the resonant capacitor(s). This means that at high load, a very powerful signal will be transmitted through the second feedback at the control circuit that will change the operation of the circuit into a charge mode operation.

Abstract: Enterprise resource planning systems can be configured to help businesses keep track of events that could affect one or more supply chains. A key purpose for such a system is to ensure a smooth flow of goods or services from suppliers to purchasers. One way to help ensure that the supply chain is efficiently maintained is to set alerts when events occur. However, alerts are usually not flexible or as easy to use as users would like. An apparatus and methods are provided for facilitating the creation and use of user-defined event rules for aggregate fields. Aggregate fields are defined by a user, who can also define one or more rules relative to the aggregate field.

Abstract: An esterase isolated from Aspergillus oryzae is capable of stereoselective hydrolysis of chiral esters and also has arylesterase activity (EC 3.1.1.2) and feruloyl esterase activity (EC 3.1.1.73). The esterase has only a limited homology to known amino acid sequences.

Abstract: The present invention discloses a method for production of novel carbamylated erythropoietin and compositions comprising the novel carbamylated erythropoietin and pharmaceutical compositions comprising this and uses thereof.

Abstract: The invention relates to a spatially encoded polymer matrix in the form of a bead or a granule for combinatorial solid phase synthesis, assaying, functional proteomics and diagnostic use. Compositions of such beads or granules are also provided. Each beaded polymer matrix of the composition comprises a plurality of spatially immobilised particles. The spatial immobilisation of the particles confers on each beaded polymer matrix a “fingerprint” which enables identification of unique beads in a population of beads. The unique identification of individual beads makes it possible to perform combinatorial chemistry strategies while logging individual chemical transformation. Also provided are methods for detection of relative positions in space of particles, methods for generating matrices, methods for distance matrix determination, methods for identifying individual matrices and devices for recording and storing images of matrices.

Abstract: The properties of dough or bread can be improved by the addition of a carbohydrate oxidase which can oxidize the reducing end of an oligosaccharide more efficiently than the corresponding monosaccharide, e.g., preferentially oxidizing maltodextrins or cellodextrins over glucose. A novel carbohydrate oxidase having the capability to oxidize maltodextrins and cellodextrins more efficiently than glucose may be obtained from a strain of Microdochium, particularly M. nivale. The amino acid sequence of the novel carbohydrate oxidase has very low homology (<20% identity) with known amino acid sequences.

Abstract: A device for determining one or more respiratory parameters relating to an individual is disclosed, as well as a method for determining one or more respiratory parameters by means of the device, wherein the individual is suffering from hypoxemia or is at risk of hypoxemia. However, the method and the device may also be applied to healthy individual e.g. for testing of medicaments. The device is controlled by a computer equipped with suitable software and includes functionality for on-line continuous data collection, automatic assessment of the timing of measurements, automatic assessment of the next target (oxygen saturation of arterial blood (SpO2)), automatic assessment of the appropriate fraction of oxygen in inspired gas (FIO2) settings to achieve the target SpO2, automatic control of the FIO2, on-line parameter estimation, and automatic assessment of the number of measurememts requied.

Abstract: The properties of dough or bread can be improved by the addition of a carbohydrate oxidase which can oxidize the reducing end of an oligosaccharide more efficiently than the corresponding monosaccharide, e.g., preferentially oxidizing maltodextrins or cellodextrins over glucose. A novel carbohydrate oxidase having the capability to oxidize maltodextrins and cellodextrins more efficiently than glucose may be obtained from a strain of Microdochium, particularly M. nivale. The amino acid sequence of the novel carbohydrate oxidase has very low homology (<20% identity) with known amino acid sequences.