Patents by Inventor Soren Knudsen
Soren Knudsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11884972Abstract: In traditional plant breeding approaches, chemical mutagenesis may be utilized to introduce nucleotide substitutions at random in the genome of a plant, i.e. without possibilities to control the sites of nucleotide changes. Because of genome complexities, the statistical probability is extremely little when it comes to finding a predetermined nucleotide substitution. The present invention, however, demonstrates how a novel, alternative use of digital polymerase chain reaction (dPCR), preferably droplet dPCR (ddPCR), is developed to exploit finding of specific nucleotide substitutions in mutated genes. The entire platform comprises a screening method with a library of mutagenized organisms, digital PCR-based systems and a set-up to propagate and analyze identified, mutated organisms.Type: GrantFiled: June 23, 2017Date of Patent: January 30, 2024Assignee: Carlsberg A/SInventors: Toni Wendt, Ole Olsen, Søren Knudsen, Hanne Cecille Thomsen, Birgitte Skadhauge, Magnus Wohlfahrt Rasmussen, Massimiliano Carciofi, Alexander Striebeck
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Patent number: 11690341Abstract: The present invention relates to barley plant or a part thereof, wherein the kernels of said barley plant have a reduced (1,3;1,4)-?-glucan content. The barley plant may carry a mutation in the CslF6 gene, wherein said mutated CslF6 gene encodes a mutant CslF6 polypeptide.Type: GrantFiled: December 21, 2018Date of Patent: July 4, 2023Assignee: Carlsberg A/SInventors: Søren Knudsen, Sabrina Bodevin, Ole Olsen, Hanne Thomsen, Toni Wendt, Jesper Harholt, Finn Lok
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Publication number: 20230111237Abstract: The present invention provides barley plants, or parts thereof, having a high limit dextrinase activity. In particular, barley plants carrying a mutation in HvLDI gene are provided. Furthermore, plant products prepared from said barley plants, or parts thereof, are described as well as methods of producing the same.Type: ApplicationFiled: March 1, 2021Publication date: April 13, 2023Applicant: Carlsberg A/SInventors: Ole Olsen, Finn Lok, Søren Knudsen, Lucia Marri, Alexander Striebeck, Pai Rosager Pedas, Jose Antonio Cuesta-Seijo, Hanne Cecilie Thomsen, Katarzyna Birch Braune
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Publication number: 20220389353Abstract: The present invention relates to methods for preparing cereal-based beverages. Particularly, the present invention provides, for example, methods for steeping and germination of cereal grain under continuous aeration. The present invention also provides for wet milling of germinated cereal grains and direct transfer of the germinated grain, without drying, to the brewery for further processing. Compared to current methods the methods of the present invention significantly reduces water consumption, energy consumption and transport need.Type: ApplicationFiled: May 31, 2022Publication date: December 8, 2022Applicant: Carlsberg Breweries A/SInventors: Birgitte Skadhauge, Finn Lok, Søren Knudsen, Toni Wendt, Katarzyna Krucewicz, Lucia Marri, Ole Olsen
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Publication number: 20220312707Abstract: The present invention provides methods of preparing plants, with specific predetermined mutation(s) in one or more NOI(s). The specific predetermined mutation(s) preferably may result in the identification of plants having desired traits.Type: ApplicationFiled: April 7, 2022Publication date: October 6, 2022Applicant: Carlsberg A/SInventors: Birgitte Skadhauge, Soren Knudsen, Gustav Hambraeus, Toni Wendt, Magnus Rasmussen, Jeppe Thulin Østerberg, Ross Fennessy
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Patent number: 11384322Abstract: The present invention relates to methods for preparing cereal-based beverages. Particularly, the present invention provides, for example, methods for steeping and germination of cereal grain under continuous aeration. The present invention also provides for wet milling of germinated cereal grains and direct transfer of the germinated grain, without drying, to the brewery for further processing. Compared to current methods the methods of the present invention significantly reduces water consumption, energy consumption and transport need.Type: GrantFiled: June 23, 2017Date of Patent: July 12, 2022Assignee: Carlsberg Breweries A/SInventors: Birgitte Skadhauge, Finn Lok, Søren Knudsen, Toni Wendt, Katarzyna Krucewicz, Lucia Marri, Ole Olsen
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Publication number: 20210395762Abstract: The invention relates to barley plants having a high ?-amylase activity. The barley plants of the invention may for example carry a mutation in one or more ?-amylase promoters, in the HRT gene, in the HBL12 gene and/or in the WRKY38 gene. The invention further provides plant products prepared from said barley plants.Type: ApplicationFiled: December 21, 2018Publication date: December 23, 2021Inventors: Christoph Dockter, Pai Rosager Pedas, Søren Knudsen, Ole Olsen, Lucia Marri, Katarzyna Krucewicz, Finn Lok, Toni Wendt, Massimiliano Carciofi, Hanne Thomsen, Magnus Rasmussen
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Publication number: 20210062208Abstract: The present invention relates to barley plant or a part thereof, wherein the kernels of said barley plant have a reduced (1,3;1,4)-?-glucan content. The barley plant may carry a mutation in the CslF6 gene, wherein said mutated CslF6 gene encodes a mutant CslF6 polypeptide.Type: ApplicationFiled: December 21, 2018Publication date: March 4, 2021Inventors: Søren Knudsen, Sabrina Bodevin, Ole Olsen, Hanne Thomsen, Toni Wendt, Jesper Harholt, Finn Lok
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Publication number: 20210062120Abstract: The present invention relates to methods for preparing cereal-based beverages. The present invention provides, for example, methods for steeping and germination of cereal grain under continuous aeration. Particularly, the present invention provides methods for heating the germinated cereal grains prior to wet milling of germinated cereal grains and direct transfer of the germinated grain, without drying, to the brewery for further processing. Compared to current methods the methods of the present invention significantly reduce water consumption, energy consumption and transport need.Type: ApplicationFiled: December 21, 2018Publication date: March 4, 2021Inventors: Finn Lok, Katarzyna Krucewicz, Lucia Marri, Birgitte Skadhauge, Søren Knudsen, Toni Wendt, Ole Olsen
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Publication number: 20200002657Abstract: The present invention relates to methods for preparing cereal-based beverages. Particularly, the present invention provides, for example, methods for steeping and germination of cereal grain under continuous aeration. The present invention also provides for wet milling of germinated cereal grains and direct transfer of the germinated grain, without drying, to the brewery for further processing. Compared to current methods the methods of the present invention significantly reduces water consumption, energy consumption and transport need.Type: ApplicationFiled: June 23, 2017Publication date: January 2, 2020Applicant: Carlsberg Breweries A/SInventors: Birgitte Skadhauge, Finn Lok, Søren Knudsen, Toni Wendt, Katarzyna Krucewicz, Lucia Marri, Ole Olsen
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Publication number: 20190194723Abstract: In traditional plant breeding approaches, chemical mutagenesis may be utilized to introduce nucleotide substitutions at random in the genome of a plant, i.e. without possibilities to control the sites of nucleotide changes. Because of genome complexities, the statistical probability is extremely little when it comes to finding a predetermined nucleotide substitution. The present invention, however, demonstrates how a novel, alternative use of digital polymerase chain reaction (dPCR), preferably droplet dPCR (ddPCR), is developed to exploit finding of specific nucleotide substitutions in mutated genes. The entire platform comprises a screening method with a library of mutagenized organisms, digital PCR-based systems and a set-up to propagate and analyze identified, mutated organisms.Type: ApplicationFiled: June 23, 2017Publication date: June 27, 2019Applicant: Carlsberg A/SInventors: Toni Wendt, Ole Olsen, Søren Knudsen, Hanne Cecille Thomsen, Birgitte Skadhauge, Magnus Wohlfahrt Rasmussen, Massimiliano Carciofi, Alexander Striebeck
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Publication number: 20190078042Abstract: According to the invention, there is provided null-LOX-1 barley and plant products produced thereof, such as malt manufactured by using barley kernels defective in synthesis of the fatty acid-converting enzyme lipoxygenase-1. Said enzyme accounts for the principal activity related to conversion of linoleic acid into 9-hydroperoxy octadecadienoic acid, a lipoxygenase pathway metabolite, which—through further enzymatic or spontaneous reactions—may lead to the appearance of trans-2-nonenal. The invention enables brewers to produce a beer devoid of detectable trans-2-nonenal-specific off-flavors, even after prolonged storage of the beverage.Type: ApplicationFiled: September 28, 2018Publication date: March 14, 2019Applicant: CARLSBERG A/SInventors: Klaus BREDDAM, Ole OLSEN, Birgitte SKADHAUGE, Finn LOK, Soren KNUDSEN, Lene Molskov BECH
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Patent number: 9834760Abstract: According to the invention, there is provided barley-derived beverages characterized by notably reduced levels of both dimethyl sulfide (DMS) and/or its precursor S-methyl-L-methionine (SMM), or lacking said compounds. In addition, the invention relates to methods for producing the above-mentioned beverages—and also to barley plants useful in the preparation of such beverages, as well as other plant products prepared from said plants. Utilization of the invention clears the way for making improved production procedures of beverages with improved taste profiles, and promises also for notable reductions in the thermal energy input for production of beer.Type: GrantFiled: December 1, 2009Date of Patent: December 5, 2017Assignees: CARLSBERG BREWERIES A/S, HEINEKEN SUPPLY CHAIN B.V.Inventors: Søren Knudsen, Gustav Hambraeus, Lene Molskov Bech, Steen Bech Sørensen, Birgitte Skadhauge, Klaus Breddam, Ole Olsen
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Publication number: 20170183611Abstract: Barley based beverages are produced in large quantities, employing highly energy consuming methods, for example in the malting and brewhouse facilities for kiln drying and wort boiling operations, respectively. The present invention relates to energy saving methods for preparing barley based beverages, as well as to barley plants useful in such methods. In particular, the invention describes barley plants with combined traits of null-lipoxygenase-1 (null-LOX-1), null-lipoxygenase-2 (null-LOX-2) and null-S-adenosylmethionine:methionine S-methyltransferase in one plant, which is particularly useful for energy saving methods to prepare barley based beverages, such as beer.Type: ApplicationFiled: January 23, 2017Publication date: June 29, 2017Applicants: Carlsberg Breweries A/S, Heineken Supply Chain B.V.Inventors: Søren Knudsen, Preben Riis, Birgitte Skadhauge, Lene Molskov Bech, Ole Olsen
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Patent number: 9587210Abstract: Barley based beverages are produced in large quantities, employing highly energy consuming methods, for example in the malting and brewhouse facilities for kiln drying and wort boiling operations, respectively. The present invention relates to energy saving methods for preparing barley based beverages, as well as to barley plants useful in such methods. In particular, the invention describes barley plants with combined traits of null-lipoxygenase-1 (null-LOX-1), null-lipoxygenase-2 (null-LOX-2) and null-S-adenosylmethionine:methionine S-methyltransferase in one plant, which is particularly useful for energy saving methods to prepare barley based beverages, such as beer.Type: GrantFiled: May 31, 2011Date of Patent: March 7, 2017Assignees: CARLSBERG BREWERIES A/S, HEINEKEN SUPPLY CHAIN B.V.Inventors: Søren Knudsen, Preben Riis, Birgitte Skadhauge, Lene Mølskov Bech, Ole Olsen
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Patent number: 9363959Abstract: According to the invention, there is provided barley with total loss of functional lipoxygenase (LOX)-1 and LOX-2 enzymes, and plant products produced thereof, such as malt manufactured by using barley kernels defective in the synthesis of the fatty acid-dioxygenating enzymes LOX-1 and LOX-2. Said enzymes account for the principal activities related to dioxygenation of linoleic acid into 9- and 13-hydroperoxy octadecadienoic acid, respectively. 9-Hydroperoxy octadecadienoic acid represents a LOX pathway metabolite, which—through further enzymatic or spontaneous reactions—may lead to the appearance of trans-2-nonenal (T2N). The invention enables brewers to produce a beer having insignificant levels of stale, T2N-specific off-flavors, even after prolonged storage of the beverage.Type: GrantFiled: December 28, 2009Date of Patent: June 14, 2016Assignees: CARLSBERG BREWERIES A/S, HEINEKEN SUPPLY CHAIN B.V.Inventors: Birgitte Skadhauge, Finn Lok, Klaus Breddam, Ole Olsen, Lette Mølskov Bech, Søren Knudsen
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Publication number: 20150218498Abstract: According to the invention, there is provided null-LOX-1 barley and plant products produced thereof, such as malt manufactured by using barley kernels defective in synthesis of the fatty acid-converting enzyme lipoxygenase-1. Said enzyme accounts for the principal activity related to conversion of linoleic acid into 9-hydroperoxy octadecadienoic acid, a lipoxygenase pathway metabolite, which-through further enzymatic or spontaneous reactions-may lead to the appearance of trans-2-nonenal. The invention enables brewers to produce a beer devoid of detectable trans-2-nonenal-specific off flavors, even after prolonged storage of the beverage.Type: ApplicationFiled: May 16, 2014Publication date: August 6, 2015Applicant: CARLSBERG A/SInventors: Klaus BREDDAM, Ole OLSEN, Birgitte SKADHAUGE, Finn LOK, Soren KNUDSEN, Lene Molskov BECH
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Publication number: 20130095207Abstract: Barley based beverages are produced in large quantities, employing highly energy consuming methods, for example in the malting and brewhouse facilities for kiln drying and wort boiling operations, respectively. The present invention relates to energy saving methods for preparing barley based beverages, as well as to barley plants useful in such methods. In particular, the invention describes barley plants with combined traits of null-lipoxygenase-1 (null-LOX-1), null-lipoxygenase-2 (null-LOX-2) and null-S-adenosylmethionine:methionine S-methyltransferase in one plant, which is particularly useful for energy saving methods to prepare barley based beverages, such as beer.Type: ApplicationFiled: May 31, 2011Publication date: April 18, 2013Applicants: HEINEKEN SUPPLY CHAIN B.V., CARLSBERG BREWERIES A/SInventors: Søren Knudsen, Preben Rils, Birgitte Skadhauge, Lene Mølskov Bech, Ole Olsen
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Publication number: 20110318469Abstract: According to the invention, there is provided barley with total loss of functional lipoxygenase (LOX)-1 and LOX-2 enzymes, and plant products produced thereof, such as malt manufactured by using barley kernels defective in the synthesis of the fatty acid-dioxygenating enzymes LOX-1 and LOX-2. Said enzymes account for the principal activities related to dioxygenation of linoleic acid into 9- and 13-hydroperoxy octadecadienoic acid, respectively. 9-Hydroperoxy octadecadienoic acid represents a LOX pathway metabolite, which—through further enzymatic or spontaneous reactions—may lead to the appearance of trans-2-nonenal (T2N). The invention enables brewers to produce a beer having insignificant levels of stale, T2N-specific off-flavors, even after prolonged storage of the beverage.Type: ApplicationFiled: December 28, 2009Publication date: December 29, 2011Applicants: Heineken Supply Chain B.V., Carlsberg Breweries A//SInventors: Birgitte Skadhauge, Finn Lok, Klaus Breddam, Ole Olsen, Lene Molskov Bech, Soren Knudsen
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Publication number: 20110293779Abstract: According to the invention, there is provided barley-derived beverages characterized by notably reduced levels of both dimethyl sulfide (DMS) and/or its precursor S-methyl-L-methionine (SMM), or lacking said compounds. In addition, the invention relates to methods for producing the above-mentioned beverages—and also to barley plants useful in the preparation of such beverages, as well as other plant products prepared from said plants. Utilization of the invention clears the way for making improved production procedures of beverages with improved taste profiles, and promises also for notable reductions in the thermal energy input for production of beer.Type: ApplicationFiled: December 1, 2009Publication date: December 1, 2011Applicants: Heineken Supply Chain B.V., Carlsberg Breweries A/SInventors: Søren Knudsen, Gustav Hambraeus, Lene Molskov Bech, Steen Bech Sorensen, Birgitte Skadhauge, Klaus Breddam, Ole Olsen