Abstract: Coherent light (e.g., laser light) is emitted into a tissue sample through an optical fiber. The tissue sample diffuses the coherent light. Different blood flow quantities generate different coherent light interference patterns. An image of a coherent light interference pattern is captured with an image sensor coupled to an optical fiber. The speckle contrast of the image quantifies coherent light interference pattern. The speckle contrast is determined and is mapped to blood flow quantities using one or more data models. A quantity of blood flow is identified in a tissue sample at least partially based on the speckle contrast value of the captured image.

Abstract: To achieve wavelength stabilization in pulsed lasers, a laser oscillator and a laser amplifier are driven with currents in a pre-lasing stage and a lasing stage. The laser oscillator is co-packaged with the laser amplifier.

Abstract: One or more ultrasonic transducers are driven to direct a therapeutic ultrasound signal into tissue. The therapeutic ultrasound signal has a resonant ultrasound frequency to harmonically excite and damage abnormal tissue but not harmonically excite healthy tissue.

Abstract: A wearable device includes one or more ultrasonic emitters disposed to direct a therapeutic ultrasound signal into tissue. The therapeutic ultrasound signal has a resonant ultrasound frequency to harmonically excite blood clots to liquify the blood clot to become soluble to blood flowing through the head.

Abstract: An anti-tumor agent is provided to a patient to increase a susceptibility of a tumor within the patient to harmonic excitation. Ultrasonic transducers of a wearable are driven to direct a therapeutic ultrasound signal into tissue of the patient. The therapeutic ultrasound signal has a resonant ultrasound frequency to harmonically excite and damage the tumor while the anti-tumor agent has increased the susceptibility of the tumor to the harmonic excitation of the therapeutic ultrasound signal.

Abstract: A health message is received. At least one target brain region is selected in response to receiving the health message. An ultrasound modality profile based on the health message and the at least one target brain region is generated. A wearable therapeutic ultrasound device directs the ultrasound beams to the at least one target brain region in response to the health message. The ultrasound beams are driven with the ultrasound beam profile.

Abstract: An ultrasound emitter launches an ultrasonic signal into a diffuse medium such as tissue. The diffuse medium is illuminated with an infrared illumination signal. activating an ultrasound emitter to launch an ultrasonic signal into a diffuse medium. An infrared reference beam is interfered with an infrared exit signal having an infrared wavelength that is the same as the infrared illumination signal. An infrared image is captured of the interference of the infrared reference beam with the infrared exit signal.

Abstract: Coherent light (e.g., laser light) is emitted into a cranium through an optical fiber. A tissue sample (e.g., red blood cells, blood vessels, brain tissue) within the cranium diffuses the coherent light. Different tissue sample motion quantities generate different coherent light interference patterns. An image of a coherent light interference pattern is captured with an image sensor coupled to an optical element. The speckle contrast of the image quantifies coherent light interference pattern. A waveform of sequentially captured speckle contrast values over time has characteristics that reflect intracranial blood flow health. If waveform characteristics indicate poor or questionable intracranial blood flow heath, a notification message is displayed, played, or otherwise transmitted.

Abstract: A first optical measurement of tissue with a first optical device is initiated. The first optical measurement includes a first shallow optical reading and a first deeper optical reading. A second optical measurement of the tissue with a second optical device spaced is initiated. The second optical device is spaced apart from the first optical device. The second optical measurement includes a second shallow optical reading and a second deeper optical reading. A first difference value between the first shallow optical reading and the first deeper optical reading is determined. A second difference value between the second shallow optical reading and the second deeper optical reading is determined. A large vessel occlusion (LVO) alert is generated when a ratio of the first difference value to the second difference value is larger than a threshold value.

Abstract: A large vessel occlusion (LVO) alert generated by a point-of-care diagnostic system is received. The LVO alert is representative of a probability of an LVO event in a patient. A mapping coordinate is received. A database of care centers proximate to the mapping coordinate is accessed. A preferred care center from the database is selected based at least on a treatment capability associated with the preferred care center and a distance of the care centers to the mapping coordinate. An LVO event notification is transmitted to initiate stroke medical care.

Abstract: Laser light is emitted from a laser into a scattering layer. An ultrasound signal is emitted into a sample. A signal is generated with a light detector in response to a measurement beam of laser light exiting the light scattering layer into the light detector. At least a portion of the measurement beam formed between the laser and the light detector is wavelength-shifted by the ultrasound signal subsequent to the ultrasound signal propagating through the sample.

Abstract: A first signal is generated with a first light detector in response to an ultrasound signal encountering a first measurement beam. A second signal is generated with a second light detector in response to the ultrasound signal encountering a second measurement beam. The second measurement beam propagates through the sample and the first measurement beam propagates outside the sample.

Abstract: A first signal is generated with a first light detector in response to an ultrasound signal encountering a first measurement beam. A second signal is generated with a second light detector in response to the ultrasound signal encountering a second measurement beam. The second measurement beam propagates through the sample and the first measurement beam propagates outside the sample.

Abstract: Laser light is emitted from a laser into a scattering layer. An ultrasound signal is emitted into a sample. A signal is generated with a light detector in response to a measurement beam of laser light exiting the light scattering layer into the light detector. At least a portion of the measurement beam formed between the laser and the light detector is wavelength-shifted by the ultrasound signal subsequent to the ultrasound signal propagating through the sample.

Abstract: Coherent light (e.g., laser light) is emitted into a tissue sample through an optical fiber. The tissue sample diffuses the coherent light. Different blood flow quantities generate different coherent light interference patterns. An image of a coherent light interference pattern is captured with an image sensor coupled to an optical fiber. The speckle contrast of the image quantifies coherent light interference pattern. The speckle contrast is determined and is mapped to blood flow quantities using one or more data models. A quantity of blood flow is identified in a tissue sample at least partially based on the speckle contrast value of the captured image.

Abstract: A system or a device for imaging includes an infrared light source, an optical structure, and a sensor. The sensor may include an image pixel array. The infrared light generates an infrared illumination signal for illuminating a diffuse medium such as tissue. An optical structure is configured to facilitate an interference of an infrared reference beam and an infrared exit signal. The infrared reference beam has a same infrared wavelength as the infrared illumination signal. The image pixel array is configured to capture holographic infrared images of the interference of the infrared reference beam and the infrared exit signal.

Abstract: An ultrasound emitter launches an ultrasonic signal into a diffuse medium such as tissue. The diffuse medium is illuminated with an infrared illumination signal. activating an ultrasound emitter to launch an ultrasonic signal into a diffuse medium. An infrared reference beam is interfered with an infrared exit signal having an infrared wavelength that is the same as the infrared illumination signal. An infrared image is captured of the interference of the infrared reference beam with the infrared exit signal.

Abstract: A semiconductor die is inspected using an optical microscope to generate a test image of the semiconductor die. A difference image between the test image of the semiconductor die and a reference image is derived. For each defect of a plurality of defects for the semiconductor die, a point-spread function is fit to the defect as indicated in the difference image and one or more dimensions of the fitted point-spread function are determined. Potential defects of interest in the plurality of defects are distinguished from nuisance defects, based at least in part on the one or more dimensions of the fitted point-spread function for respective defects of the plurality of defects.

Abstract: A semiconductor die is inspected using an optical microscope to generate a test image of the semiconductor die. A difference image between the test image of the semiconductor die and a reference image is derived. For each defect of a plurality of defects for the semiconductor die, a point-spread function is fit to the defect as indicated in the difference image and one or more dimensions of the fitted point-spread function are determined. Potential defects of interest in the plurality of defects are distinguished from nuisance defects, based at least in part on the one or more dimensions of the fitted point-spread function for respective defects of the plurality of defects.

Abstract: Methods and systems for determining boundaries of patterned features formed on a specimen from an unresolved image of the specimen are provided. One system includes computer subsystem(s) configured for comparing a difference image in which patterned feature(s) are unresolved to different simulated images. The different simulated images are generated by simulating difference images generated for the patterned feature(s) formed on the specimen with different perturbations, respectively. The computer subsystem(s) are configured for, based on the comparing, assigning an amplitude to each of the different perturbations. The computer subsystem(s) are further configured for determining one or more boundaries of the patterned feature(s) formed on the specimen by applying the different perturbations to one or more designed boundaries of the patterned feature(s) with the assigned amplitudes.