Abstract: The present invention relates to the ranking/selection of tumor-specific neoantigens of a subject having cancer. The present invention also provides methods using the ranked/selected tumor-specific neoantigens in, for example, the treatment or prevention of cancer. Ranked and selected neoantigens may be used as biomarkers in the diagnosis, monitoring and/or prognosis of tumor diseases.

Abstract: The present invention relates to a nucleic acid molecule which encodes a splice variant of the human P2RX7 receptor, and nucleic acid molecules derived therefrom, a recombinant vector containing said nucleic acid molecules, a host containing said recombinant vector, a polypeptide encoded by said nucleic acid molecules, a host cell expressing said polypeptide, a binding molecule binding to said polypeptide, a pharmaceutical composition comprising said binding molecule, a method for the production of the isolated polypeptide, and other methods and uses in connection therewith.

Abstract: Methods for personalized neoantigen or neoepitope selection for a patient having cancer, whereby the patient can be treated in a personalized manner using a patient-specific cocktail of suitable neoantigen or neoepitope peptides and a pharmaceutically acceptable excipient, wherein the selection of suitable neoantigens or neoepitopes is based on properties of the patient-specific neoantigens or neoepitopes which are predicted or evaluated based on information derived from databases which in turn are derived from prior measurements and observations, and wherein the method reduces the influence of any errors in the underlying databases by binning certain descriptors of neoantigen or neoepitope properties and by improved ranking of the neonantigens or neoepitopes according to the binning of the descriptors; and pharmaceutical preparations selected by said methods, and data carriers and kits for carrying out said methods.

Abstract: The present invention relates to a nucleic acid molecule which encodes a splice variant of the human P2RX7 receptor, and nucleic acid molecules derived therefrom, a recombinant vector containing said nucleic acid molecules, a host containing said recombinant vector, a polypeptide encoded by said nucleic acid molecules, a host cell expressing said polypeptide, a binding molecule binding to said polypeptide, a pharmaceutical composition comprising said binding molecule, a method for the production of the isolated polypeptide, and other methods and uses in connection therewith.

Abstract: The present invention relates to a genetically modified Paramyxovirus, a pharmaceutical composition comprising this paramyxovirus, the use of a genetically modified Paramyxovirus for the therapeutic and/or prophylactic treatment of a tumor disease, and a method for the production of a pharmaceutical composition for the therapeutic or prophylactic treatment of a tumor disease.