Abstract: This invention provides a method for protein patterning and fabrication of biomolecule microarrays, based on the selective biomolecule adsorption on hydrophilic versus hydrophobic patterns created by selective plasma deposition of fluorocarbon film.

Abstract: An integrated optoelectronic silicon biosensor that can detect biomolecules by the change of the optical coupling between the integrated light source and the integrated detector that is caused by the binding of the appropriately labeled analytes onto the recognition molecules, that have been previously immobilized onto the integrated optical fiber that connects the optical source with the detector. The device contains the optoelectronic silicon chip and its biological activation. The optoelectronic chip is realized following integrated circuits fabrication methods so as the light source, the detector and the optical fiber, that optically couples the light source with the detector, to be monolithically integrated on the same silicon substrate. The biological activation of the chip is performed through physicochemical modification of the chip surface in order to permit immobilization of the recognition biomolecules onto the optical fiber surface.

Abstract: Novel photoresist materials, which can be photolithographically processed in biocompatible conditions are presented in this invention. Suitable lithographic scheme for the use of these and analogous resists for biomolecule layer patterning on solid substrates are also described. The processes described enable micropatterning of more than two different proteins on solid substrates without denaturation of the proteins. The preferred resist materials are based on (meth)acrylate copolymers that contain at least one acid cleavable ester group and at least one hydrophilic group such as an alcoholic or a carboxylic group.

Abstract: An integrated optoelectronic silicon biosensor that can detect biomolecules by the change of the optical coupling between the integrated light source and the integrated detector that is caused by the binding of the appropriately labeled analytes onto the recognition molecules, that have been previously immobilized onto the integrated optical fiber that connects the optical source with the detector. The device contains the optoelectronic silicon chip and its biological activation. The optoelectronic chip is realized following integrated circuits fabrication methods so as the light source, the detector and the optical fiber, that optically couples the light source with the detector, to be monolithically integrated on the same silicon substrate. The biological activation of the chip is performed through physicochemical modification of the chip surface in order to permit immobilization of the recognition biomolecules onto the optical fiber surface.