Patents by Inventor Sou Nakamura

Sou Nakamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210222124
    Abstract: The present invention provides a method for producing megakaryocytes that have an increased capacity to produce platelets, the method comprising a step of culturing, under conditions that cause the death of cells that do not express a gene that is specifically expressed by megakaryocytes, cells that have the capacity to differentiate into megakaryocytes.
    Type: Application
    Filed: March 22, 2021
    Publication date: July 22, 2021
    Inventors: Takeaki Dohda, Sachiko Kobayashi, Koji Eto, Hiroshi Endo, Sou Nakamura
  • Publication number: 20210130781
    Abstract: Methods of production and apparatuses for production for stably producing healthy and functional platelets, and methods for determining operating conditions of an apparatus for producing platelets are provided. The present invention relates to methods of production comprising a step of culturing megakaryocytes in a platelet production medium C, wherein the step of culturing comprises a step of stirring a medium C in containers 1, 4 using stirring mechanisms 2, 5. In one method of production, the step of stirring comprises reciprocating stirring blades 21, 24 in the stirring mechanisms 2, 24 such that any of predetermined turbulent energy, shearing stresses, or Kolmogorov scale is produced, in the medium C. In another method of production, the step of stirring comprises pivoting a stirring blade 51 in the stirring mechanism 5 wherein a plurality of stationary members 53 is placed therearound in a bottom region 4e of the container 4 such that the step of stirring produces turbulence in the medium C.
    Type: Application
    Filed: July 5, 2018
    Publication date: May 6, 2021
    Inventors: Koji ETO, Sou NAKAMURA, Yukitaka ITO, Tomohiro SHIGEMORI, Yoshikazu KATO
  • Patent number: 10947504
    Abstract: The present invention provides a highly functional platelet production promoting agent which comprises one or a plurality of aryl hydrocarbon receptor (AhR) antagonists and one or a plurality of Rho-associated coiled-coil forming kinase (ROCK) inhibitors.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: March 16, 2021
    Assignees: Kyoto University, Megakaryon Corporation
    Inventors: Koji Eto, Sou Nakamura, Yukitaka Ito, Tomohiro Shigemori, Takeaki Dohda
  • Publication number: 20200216807
    Abstract: Healthy functional platelets are mass produced. A method for producing platelets, comprising: (1) a culture step of culturing megakaryocytes in a platelet producing medium in the presence of mechanical stress and platelet production promoting factors including MIF, NRDc, IGFBP2, TSP-1, PAI-1, and CCL5, and (2) a harvest step of harvesting the platelets obtained by the culture step; wherein the culture step comprises: (a) a step of promoting a release of the platelet production promoting factors from megakaryocytes by mechanical stress; and/or (b) a step of externally adding platelet production promoting factors including MIF, NRDc, and IGFBP2.
    Type: Application
    Filed: March 5, 2018
    Publication date: July 9, 2020
    Inventors: KOJI ETO, SOU NAKAMURA, YUKITAKA ITO
  • Patent number: 10533185
    Abstract: An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: January 14, 2020
    Assignee: The University of Tokyo
    Inventors: Koji Eto, Hiromitsu Nakauchi, Naoya Takayama, Sou Nakamura
  • Publication number: 20190211305
    Abstract: The present invention provides a method for culturing pluripotent stem cells, comprising the step of contacting pluripotent stem cells with laminin 421 or a fragment thereof, laminin 121 or a fragment thereof, or a combination thereof.
    Type: Application
    Filed: August 25, 2017
    Publication date: July 11, 2019
    Inventors: Koji Eto, Sou Nakamura, Kiyotoshi Sekiguchi, Tomohiro Shigemori
  • Publication number: 20190048317
    Abstract: The present invention provides a highly functional platelet production promoting agent which comprises one or a plurality of aryl hydrocarbon receptor (AhR) antagonists and one or a plurality of Rho-associated coiled-coil forming kinase (ROCK) inhibitors.
    Type: Application
    Filed: June 16, 2016
    Publication date: February 14, 2019
    Inventors: Koji Eto, Sou Nakamura, Yukitaka Ito, Tomohiro Shigemori, Takeaki Dohda
  • Patent number: 10087419
    Abstract: The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage. The present invention also provides a method for producing specific cells, wherein oncogene-induced senescence (OIS) which is induced by the oncogene expressed in the cells in the desired differentiation stage is suppressed.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: October 2, 2018
    Assignee: The University of Tokyo
    Inventors: Koji Eto, Naoya Takayama, Sou Nakamura, Hiromitsu Nakauchi
  • Publication number: 20180044634
    Abstract: The present invention provides a method for producing megakaryocytes that have an increased capacity to produce platelets, the method comprising a step of culturing, under conditions that cause the death of cells that do not express a gene that is specifically expressed by megakaryocytes, cells that have the capacity to differentiate into megakaryocytes.
    Type: Application
    Filed: March 9, 2016
    Publication date: February 15, 2018
    Inventors: Takeaki Dohda, Sachiko Kobayashi, Koji Eto, Hiroshi Endo, Sou Nakamura
  • Publication number: 20180016597
    Abstract: An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.
    Type: Application
    Filed: August 18, 2017
    Publication date: January 18, 2018
    Applicant: The University of Tokyo
    Inventors: Koji Eto, Hiromitsu Nakauchi, Naoya Takayama, Sou Nakamura
  • Patent number: 9738906
    Abstract: An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: August 22, 2017
    Assignee: The University of Tokyo
    Inventors: Koji Eto, Hiromitsu Nakauchi, Naoya Takayama, Sou Nakamura
  • Publication number: 20160115449
    Abstract: The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage. The present invention also provides a method for producing specific cells, wherein oncogene-induced senescence (OIS) which is induced by the oncogene expressed in the cells in the desired differentiation stage is suppressed.
    Type: Application
    Filed: October 28, 2015
    Publication date: April 28, 2016
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Koji Eto, Naoya Takayama, Sou Nakamura, Hiromitsu Nakauchi
  • Patent number: 9200254
    Abstract: The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage. The present invention also provides a method for producing specific cells, wherein oncogene-induced senescence (OIS) which is induced by the oncogene expressed in the cells in the desired differentiation stage is suppressed.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: December 1, 2015
    Assignee: The University of Tokyo
    Inventors: Koji Eto, Naoya Takayama, Sou Nakamura, Hiromitsu Nakauchi
  • Publication number: 20140127815
    Abstract: An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.
    Type: Application
    Filed: May 11, 2012
    Publication date: May 8, 2014
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Koji Eto, Hiromitsu Nakauchi, Naoya Takayama, Sou Nakamura
  • Publication number: 20120238023
    Abstract: The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage. The present invention also provides a method for producing specific cells, wherein oncogene-induced senescence (OIS) which is induced by the oncogene expressed in the cells in the desired differentiation stage is suppressed.
    Type: Application
    Filed: September 15, 2010
    Publication date: September 20, 2012
    Inventors: Koji Eto, Naoya Takayama, Sou Nakamura, Hiromitsu Nakauchi
  • Patent number: 7742645
    Abstract: The encoding device of the present invention comprises a type determination unit inputs each bit of the weblet co-efficient in a depth direction in parallel and determines type information indicating which the bit is, the first “1” bit when viewed from an MSB side, a bit located further on the MSB side than the first “1” bit, a bit located further on an LSB side than the first “1” bit, a buffer unit for buffering the determined type information of each bit for each bit depth and a pass determination unit for determining pass information of a type information to process, of a plurality of pieces of type information, based on the plurality of pieces of buffered type information of the same depth.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: June 22, 2010
    Assignee: Fujitsu Microelectronics Limited
    Inventor: Sou Nakamura
  • Publication number: 20070217695
    Abstract: The encoding device of the present invention comprises a type determination unit inputs each bit of the weblet co-efficient in a depth direction in parallel and determines type information indicating which the bit is, the first “1” bit when viewed from an MSB side, a bit located further on the MSB side than the first “1” bit, a bit located further on an LSB side than the first “1” bit, a buffer unit for buffering the determined type information of each bit for each bit depth and a pass determination unit for determining pass information of a type information to process, of a plurality of pieces of type information, based on the plurality of pieces of buffered type information of the same depth.
    Type: Application
    Filed: October 18, 2006
    Publication date: September 20, 2007
    Applicants: FUJITSU LIMITED, FUJITSU DEVICES INC.
    Inventor: Sou NAKAMURA
  • Patent number: 5701349
    Abstract: An active vibration controller includes acceleration detectors for generating output signals on the basis of vibrations of a vehicle, speakers provided in a vehicle's cabin, microphones provided in the vehicle's cabin for receiving generated sounds from the speakers and road noises generated on the basis of running of the vehicle, and adaptive digital filters using output signals from the acceleration detectors as inputs for controlling filter factors on the basis of an RLS algorithm to minimize levels of output signals from the microphones in response to output signals from the microphones and output signals from the acceleration detectors through use of a transfer function matched to the transfer function of the vehicle's cabin in a sound field between the speakers and the microphones. The controller minimized levels of output signals from the microphones by developing an applied output signal to the speakers.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 23, 1997
    Assignee: Hokda Giken Kogyo Kabushiki Kaisha
    Inventors: Hisashi Sano, Sou Nakamura, Hideshi Sawada, Shuichi Adachi, Hideki Kasuya