Abstract: Devices, system, and methods are provided based on a technique for purging a blood pump. The technique may include providing a blood pump having an impeller and providing a fluid comprising a bicarbonate. The technique may include flowing the fluid through a first gap between a bearing and an outer surface of a rotatable shaft coupled to the impeller, the bearing and gap being disposed within a lumen of a tubular member and depending on the flow rate of the fluid and the speed of the impeller, the fluid may flow through the first gap and into a second gap between the bearing and a surface of the impeller facing the bearing. The bicarbonate reduces denaturation and adsorption of any blood proteins in the gap(s).

Abstract: The disclosure relates to systems and devices for diagnosing infectious disease (e.g., bacterial or viral infections). More particularly, the disclosure relates to acoustic sensors for detecting infectious disease caused by viral infections (e.g., coronavirus, rhinovirus, influenza, etc.).

Abstract: A method for controlled purging of a blood pump and a blood pump assembly for implementing the method are provided. The blood pump is in fluid communication with a purging device. The purging device comprises a purge reservoir and a supplemental reservoir configured to be fluidically connected to the blood pump. The purge reservoir is configured to receive a purge fluid and the supplemental reservoir configured to receive a supplemental purge fluid. At least a portion of the blood pump is inserted into a patient and operated. A flow of the purge fluid is provided from the purge reservoir to the blood pump. A purge flow parameter at the blood pump is measured using a measuring device and when it is determined by a controller that the purge flow parameter meets a predetermined threshold, a remediation protocol is identified.

Abstract: A method of operating a blood pump that is purged with a purge solution that contains a pH controlling and buffering agent combined with aqueous dextrose and a reduced amount of heparin or no heparin. The blood pump has a gap between a shaft and housing through which the purge solution flows. In operation, the purge solution exits the housing and is discharged into the patient. The purge solution is therefore required to perform lubricating and heat transfer functions in the pump yet be biocompatible with the patient.

Abstract: An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coating. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

Abstract: A blood pump with a stator and rotor wherein the rotor is assembled by bonding the stator components with epoxy. The bonding surfaces of the rotor components are primed with a silane-based primer to improve adhesion between the primer and the rotor components by rendering such surfaces hydrophobic. A bonding surface of one of the stator yoke or the stator sleeve, or both, is treated with a primer that improves wettability of the bonding surface and improves bonding of the epoxy to the binding surface. The device has a bonding surface adhered to epoxy in which a primer was applied on such bonding surface prior to introducing epoxy onto the bonding surface. In addition to improved bond strength, hydrophobic surface would control moister ingress.

Abstract: An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coaling. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

Abstract: An optical sensor assembly for use in a blood pump assembly comprising a visor affixed to a pump housing of the blood pump assembly. A support jacket is in contact with an inner surface of the visor, and defines a cavity in which an optical sensor is disposed. A silicone composition is introduced into the cavity, where it cures. The silicone composition within the cavity protects the optical sensor, and the support jacket prevents the overflowing of the silicone composition and contamination of the visor. The silicone composition comprises a silicone component and a plasticizer with a silicone to plasticizer ratio selected to provide one or more of the desired rigidity, tackiness, adhesion strength, viscosity, shelf life, pot life, and curing properties. The silicone composition may comprise more than one silicone component. A method of manufacturing the optical sensor assembly and the silicone composition.

Abstract: An acoustic wave biosensor component is provided. The acoustic wave biosensor comprising a piezoelectric substrate with or without 3D matrix microstructure to increase the surface of the effective sensing area and an anchor substance covalently bound to a surface of the piezoelectric substrate, and the anchor substance can bind to a capture reagent. A process for fabricating the 3D biosensor surface and component coating the surface of a piezoelectric material with bioactive film comprising an anchor substance is also provided.

Abstract: An acoustic wave biosensor component is provided. A method of amplifying the biosensor signal is also provided, including applying a polymer or metallic material to the analyte after the analyte is attached to the capture agent on the biosensor.

Abstract: An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coaling. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

Abstract: Disclosed is a composition immunologically targeted to Alzheimer's disease (AD), the composition containing amine functionalized nanoparticles of Cerium oxide coated with polyethylene glycol and bearing an antibody specific for an amyloid-beta antigen associated with AD. The invention also includes a medication manufactured with the targeted nanoceria particles and methods of treatment by administering the targeted nanoceria particles to patients in need thereof.

Abstract: Methods of mitigating the effects of radiation exposure or providing a radioprotective effect in a subject are provided herein. The methods include administering a therapeutically effective amount of cerium oxide nanoparticles to the subject to mitigate the effects of radiation exposure or to offer a radioprotective effect to the subject. The cerium oxide nanoparticles are suitably less than 20 nm in diameter and have over 50% of the cerium in the 3+ oxidation state.

Abstract: Disclosed is a composition immunologically targeted to Alzheimer's disease (AD), the composition containing amine functionalized nanoparticles of Cerium oxide coated with polyethylene glycol and bearing an antibody specific for an amyloid-beta antigen associated with AD. The invention also includes a medication manufactured with the targeted nanoceria particles and methods of treatment by administering the targeted nanoceria particles to patients in need thereof.

Abstract: Methods of mitigating the effects of radiation exposure or providing a radioprotective effect in a subject are provided herein. The methods include administering a therapeutically effective amount of cerium oxide nanoparticles to the subject to mitigate the effects of radiation exposure or to offer a radioprotective effect to the subject. The cerium oxide nanoparticles are suitably less than 20 nm in diameter and have over 50% of the cerium in the 3+ oxidation state.

Abstract: Methods of using cerium oxide nanoparticles to promote angiogenesis are described. In a particular embodiment, a method of promoting angiogenesis in animal tissue comprises contacting the tissue with a composition comprising cerium oxide nanoparticles effective for stimulating proliferation of endothelial cells associated with the tissue.

Abstract: A method for offering a purchase incentive from a retail merchandiser to a retail customer through a handheld customer communications device is executed at least in part by a computer system and includes receiving, at a first processor having a network address, data from an encoding that is scanned and wirelessly transmitted from the handheld customer communications device. A product that is associated with the encoding data is identified and a wireless address that is associated with the handheld customer communications device is recorded. The method further includes transmitting, from the first processor, pricing information for the identified product for display on the handheld customer communications device at the recorded wireless address and responding to a customer selection from the transmitted pricing information by transmitting an incentive message for display on the handheld customer communications device at the recorded wireless address.

Abstract: Disclosed is a composition immunologically targeted to Alzheimer's disease (AD), the composition containing amine functionalized nanoparticles of Cerium oxide coated with polyethylene glycol and bearing an antibody specific for an amyloid-beta antigen associated with AD. The invention also includes a medication manufactured with the targeted nanoceria particles and methods of treatment by administering the targeted nanoceria particles to patients in need thereof.

Abstract: Disclosed is a composition immunologically targeted to Alzheimer's disease (AD), the composition containing amine functionalized nanoparticles of Cerium oxide coated with polyethylene glycol and bearing an antibody specific for an amyloid-beta antigen associated with AD. The invention also includes a medication manufactured with the targeted nanoceria particles and methods of treatment by administering the targeted nanoceria particles to patients in need thereof.