Patents by Inventor Soumitra Roy

Soumitra Roy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190184010
    Abstract: Methods and apparatus for the reproducible, consistent and efficacious delivery of an HBV vaccine to a subject. The disclosure comprises apparatus for the controlled administration of the HBV vaccine through an orifice to the subject, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and an electrical signal generator operatively connected to the electrodes.
    Type: Application
    Filed: December 18, 2018
    Publication date: June 20, 2019
    Inventors: Daniel Boden, Helen Horton, Jean-Marc Edmond Fernand Marie Neefs, Soumitra Roy, Andrew W. Hannaman, Robert M. Bernard, Stephen A. Morse, Oliver Ruck, Adam Hartman, Thomas David Cox
  • Publication number: 20190185828
    Abstract: Polynucleotides encoding hepatitis B virus (HBV) core antigen and polymerase antigen, and related combinations are described. Also described are vectors, such as DNA plasmids or viral vectors, expressing the HBV core and polymerase antigens, and immunogenic compositions containing the expression vectors. Methods of inducing an immune response against HBV or treating a HBV-induced disease, particularly in individuals having chronic HBV infection, using the immunogenic compositions are also described.
    Type: Application
    Filed: December 18, 2018
    Publication date: June 20, 2019
    Inventors: Daniel Boden, Helen Horton, Jean-Marc Edmond Fernand Marie Neefs, Soumitra Roy
  • Publication number: 20190184011
    Abstract: Provided herein are Modified Vaccinia Ankara (MVA) vectors and adenovirus vectors encoding HBV antigens. Also provided are methods of enhancing an immune response in a human subject by utilizing the MVA and adenovirus vectors encoding HBV antigens in a prime/boost regimen to the enhance the immune response in the human subject.
    Type: Application
    Filed: December 18, 2018
    Publication date: June 20, 2019
    Inventors: Daniel BODEN, Helen HORTON, Jean-Marc Edmond Fernand Marie NEEFS, Soumitra ROY, Jerôme Hubertina Henricus Victor CUSTERS, Roland Christian ZAHN, Markus KALLA
  • Patent number: 10149873
    Abstract: Recombinant vectors comprise simian adenovirus A1321 (SAdV-A1321), SAdV-A1325, SAdV-A1295, SAdV-A1309, SAdV-A1316, and/or SAdV-A1322 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1321, SAdV-A1325, SAdV-A1295, SAdV-A1309, SAdV-A1316, and/or SAdV-A1322 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: December 11, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Soumitra Roy, James M. Wilson
  • Patent number: 10113182
    Abstract: Recombinant vectors comprise simian adenovirus A1302 (SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: October 30, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Soumitra Roy, James M. Wilson
  • Publication number: 20180016598
    Abstract: A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Application
    Filed: March 3, 2017
    Publication date: January 18, 2018
    Inventors: Soumitra Roy, James M. Wilson, Luc H. Vandenberghe
  • Publication number: 20170183636
    Abstract: A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.
    Type: Application
    Filed: March 7, 2017
    Publication date: June 29, 2017
    Inventors: Soumitra Roy, James M. Wilson, Luk H. Vandenberghe
  • Publication number: 20170119873
    Abstract: A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Application
    Filed: August 12, 2015
    Publication date: May 4, 2017
    Inventors: James M. Wilson, Guangping Gao, Soumitra Roy
  • Patent number: 9617561
    Abstract: Novel simian adenovirus 41 and two isolates thereof are described. Various uses of these isolates, including construction of a recombinant vector which comprises simian adenovirus 41 sequences and a heterologous gene under the control of regulatory sequences are provided. A cell line which expresses simian adenovirus 41 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: April 11, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Soumitra Roy, James M. Wilson, Luc H. Vandenberghe
  • Publication number: 20170096646
    Abstract: The present invention provides a method of altering the specificity of an adenovirus vector. The method involves providing an adenovirus having a capsid with a modified adenovirus hexon protein. The modified adenovirus has a capsid comprising a hexon protein with a deletion in hypervariable region 1 and/or hypervariable region 4 of the hexon and an insert of an exogenous molecule therein.
    Type: Application
    Filed: December 20, 2016
    Publication date: April 6, 2017
    Inventors: Soumitra Roy, James M. Wilson
  • Patent number: 9597363
    Abstract: A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: March 21, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Soumitra Roy, James M. Wilson, Luk H. Vandenberghe
  • Patent number: 9593346
    Abstract: A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: March 14, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Soumitra Roy, James M. Wilson, Luc H. Vandenberghe
  • Publication number: 20160271192
    Abstract: Recombinant vectors comprise simian adenovirus A1321 (SAdV-A1321), SAdV-A1325, SAdV-Al295, SAdV-A1309, SAdV-A1316, and/or SAdV-A1322 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1321, SAdV-A1325, SAdV-Al295, SAdV-A1309, SAdV-A1316, and/or SAdV-A1322 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Application
    Filed: June 3, 2016
    Publication date: September 22, 2016
    Inventors: Soumitra Roy, James M. Wilson
  • Publication number: 20160244783
    Abstract: A recombinant vector comprises simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -38 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -38 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Application
    Filed: May 13, 2016
    Publication date: August 25, 2016
    Inventors: Soumitra Roy, James M. Wilson, Luk H. Vandenberghe
  • Patent number: 9382551
    Abstract: Recombinant vectors comprise simian adenovirus A1321 (SAdV-A1321), SAdV-A1325, SAdV-A1295, SAdV-A1309, SAdV-A1316, and/or SAdV-A1322 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1321, SAdV-A1325, SAdV-A1295, SAdV-A1309, SAdV-A1316, and/or SAdV-A1322 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: July 5, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Soumitra Roy, James M. Wilson
  • Patent number: 9359618
    Abstract: A recombinant vector comprises simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -38 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -383 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: June 7, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Soumitra Roy, James M. Wilson, Luk H. Vandenberghe
  • Publication number: 20160102295
    Abstract: The present invention provides a method of altering the specificity of an adenovirus vector. The method involves providing an adenovirus having a capsid with a modified adenovirus hexon protein. The modified adenovirus has a capsid comprising a hexon protein with a deletion in hypervariable region 1 and/or hypervariable region 4 of the hexon and an insert of an exogenous molecule therein.
    Type: Application
    Filed: May 22, 2015
    Publication date: April 14, 2016
    Inventors: Soumitra Roy, James M. Wilson
  • Publication number: 20160083749
    Abstract: Recombinant vectors comprise simian adenovirus A1302 (SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Application
    Filed: December 1, 2015
    Publication date: March 24, 2016
    Inventors: Soumitra Roy, James M. Wilson
  • Publication number: 20160051603
    Abstract: A recombinant vector comprises simian adenovirus 28, simian adenovirus 27, simian adenovirus 32, simian adenovirus 33, and/or simian adenovirus 35 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-28, -27, -32, -33, or -35 genes is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Application
    Filed: November 3, 2015
    Publication date: February 25, 2016
    Inventors: Soumitra Roy, James M. Wilson, Luk H. Vandenberghe
  • Patent number: 9217159
    Abstract: Recombinant vectors comprise simian adenovirus A1302 (SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: December 22, 2015
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Soumitra Roy, James M. Wilson