Abstract: Aspects of the present disclosure provide systems, methods, and computer-readable storage media that support adaptive machine learning (ML) classification that mitigates effects of catastrophic forgetting while reducing overall resource requirements. To illustrate, a computing device may train first and second ML classifiers based on historical streamed data. The second ML classifier is trained to use continuous learning, and the first ML classifier is not. If data drift of a data stream is below a lower threshold, the data stream is provided as input to the first ML classifier to generate classification output (e.g., predictions). If the data drift is above the lower threshold, dynamic switching occurs and the data stream is provided as input to the second ML classifier instead of the first ML classifier to generate the classifier output. If the data drift is above an upper threshold, operations are performed to train new ML classifiers.

Abstract: Malaria remains a major concern of morbidity and mortality. Despite treating infected individuals with artemisinin-based combination therapies (ACTs), cerebral and severe malaria cause enormous mortality in children and adults. The only treatment option is parenteral administration of artemisinin or quinine with supportive symptomatic therapies. However, the fatality rate remains high despite parasite clearance emphasizing the need of adjunct therapy to prevent malaria mortality. In this invention, heme synthesized in the malaria parasite is shown to be associated with parasite virulence, disease severity and cerebral pathogenesis. Parasite heme enhances the formation of hemozoin—a parasite molecule associated with cerebral and severe malaria. Griseofulvin prevents experimental cerebral malaria (ECM) by inhibiting parasite heme synthesis and hemozoin formation, without affecting parasite growth. Griseofulvin exhibits synergy with arteether—the principal component of ACTs and prevents ECM.

Abstract: Aspects of the present disclosure provide systems, methods, and computer-readable storage media that support dynamically updated ensemble-based machine learning (ML) classification. An ensemble of ML classifiers may be created from a plurality of trained ML classifiers. These initial ML classifiers may be trained using labeled data to generate predictions based on input data. When an unlabeled data stream is received, the unlabeled data stream may be provided as input to the ensemble to generate predictions. After obtaining labels for the received data, the labels and the unlabeled data stream may be used to train new ML classifiers. The new ML classifiers may replace older ML classifiers in the ensemble. In this manner, the ensemble of ML classifiers is used to perform predictions on high volume streaming data while being dynamically updated with ML classifiers that have learned changes in statistical distribution across more recent input data.

Abstract: A method for intelligently reading displayed contents by an electronic device is provided. The method includes obtaining a screen representation based on a plurality of contents displayed on a screen of the electronic device. The method includes extracting a plurality of insights comprising at least one of intent, importance, emotion, sound representation and information sequence of the plurality of contents from the plurality of contents based on the screen representation. The method includes generating audio emulating the extracted plurality of insights.

Abstract: Surgical tools and robotic systems adaptable for treating a left side or a right side of a patient with minimal interference with the patient and surrounding operative site are disclosed. In some embodiments, a surgical tool can include a body, an end-effector, a first connector, a second connector, and a third connector. The end-effector can extend from a distal end of the body and be movable relative to the body about a pivot axis. The first connector can rigidly secure the body to a planar mechanism. The second and third connectors can rigidly secure a distal part and a proximal part of a tracker, respectively, to the body. The first and second connectors can be symmetrical to each other with respect to a plane including a longitudinal axis of the body and the pivot axis and can be suited for attachment of either the tracker or the planar mechanism.

Abstract: Implementations are provided herein for data deduplication, and more particularly, to post-process data deduplication on a large scale out storage system. Multiple techniques and implementations are disclosed that offer greater efficiency, higher performance, and more stability when performing post-process data deduplication at large scale. Disclosed implementations are based on a process for data deduplication involving four main phases: enumeration, commonality, sharing, and update. Multi-level hashing can be used to identify candidates for deduplication during the enumeration phase, providing a more efficient use of compute resources. In addition, datasets can be phase rotated through the post-process deduplication steps providing a more controllable deduplication environment as well as a more efficient use of resources.

Abstract: A cluster manager manages copies of a mid-tier database as a mid-tier database cluster. The cluster manager may concurrently manage a backend database system. The cluster manager is configured to monitor for and react to failures of mid-tier database nodes. The cluster manager may react to a mid-tier database failure by, for example, assigning a new active node, creating a new standby node, creating new copies of the mid-tier databases, implementing new replication or backup schemes, reassigning the node's virtual address to another node, or relocating applications that were directly linked to the mid-tier database to another host. Each node or an associated agent may configure the cluster manager during initialization, based on common cluster configuration information. Each copy of the mid-tier database may be, for example, a memory resident database. Thus, a node must reload the entire database into memory to recover a copy of the database.

Abstract: A replication track is a designated group of transactions that are to be replicated at a destination database in a way that, with respect to any other transaction in the replication track, preserves transactional dependency. Further, transactions in a replication track can be replicated at the destination database without regard to transactional dependency of other transactions in another track. This facilitates concurrent parallel replication of transactions of different tracks. Replicating data in this manner is referred to herein as track replication. An application may request execution of transactions and designate different tracks for transactions.

Abstract: A multi-function impactor for use with an orthopaedic implant, such as a knee joint, is described. The head of the impactor has a pair of curved recesses for mating with condylar parts of a femoral implant and flat faces for mating with a tibial implant. An extended formation is also provided for use with the inter-condylar notch of the femoral implant. A v-shaped notch in the extended formation is also provided to impact a tibial insert. The impactor can be made from a single moulded plastics part.

Abstract: A replication track is a designated group of transactions that are to be replicated at a destination database in a way that, with respect to any other transaction in the replication track, preserves transactional dependency. Further, transactions in a replication track can be replicated at the destination database without regard to transactional dependency of other transactions in another track. This facilitates concurrent parallel replication of transactions of different tracks. Replicating data in this manner is referred to herein as track replication. An application may request execution of transactions and designate different tracks for transactions.

Abstract: A cluster manager is configured to manage a plurality of copies of a mid-tier database as a mid-tier database cluster. The cluster manager may concurrently manage a backend database system. The cluster manager is configured to monitor for and react to failures of mid-tier database nodes. The cluster manager may react to a mid-tier database failure by, for example, assigning a new active node, creating a new standby node, creating new copies of the mid-tier databases, implementing new replication or backup schemes, reassigning the node's virtual address to another node, or relocating applications that were directly linked to the mid-tier database to another host. Each node or an associated agent may configure the cluster manager to behave in this fashion during initialization, based on common cluster configuration information. Each copy of the mid-tier database may be, for example, a memory resident database. Thus, a node must reload the entire database into memory to recover a copy of the database.

Abstract: A multi-function impactor for use with an orthopaedic implant, such as a knee joint, is described. The head of the impactor has a pair of curved recesses for mating with condylar parts of a femoral implant and flat faces for mating with a tibial implant. An extended formation is also provided for use with the inter-condylar notch of the femoral implant. A v-shaped notch in the extended formation is also provided to impact a tibial insert. The impactor can be made from a single moulded plastics part.

Abstract: A cluster manager is configured to manage a plurality of copies of a mid-tier database as a mid-tier database cluster. The cluster manager may concurrently manage a backend database system. The cluster manager is configured to monitor for and react to failures of mid-tier database nodes. The cluster manager may react to a mid-tier database failure by, for example, assigning a new active node, creating a new standby node, creating new copies of the mid-tier databases, implementing new replication or backup schemes, reassigning the node's virtual address to another node, or relocating applications that were directly linked to the mid-tier database to another host. Each node or an associated agent may configure the cluster manager to behave in this fashion during initialization, based on common cluster configuration information. Each copy of the mid-tier database may be, for example, a memory resident database. Thus, a node must reload the entire database into memory to recover a copy of the database.

Abstract: A variable friction disc brake for use with a C-arm x-ray imaging apparatus interposed between the support arm and yoke of the imaging apparatus. The variable friction disc is generally comprised of ring having a gap, width both sides of said gap having apertures therethrough such that a bolt may be inserted into said apertures and used to adjust the width of the gap, and the tension on the ring.

Abstract: A variable friction disc brake for use with a C-arm x-ray imaging apparatus interposed between the support arm and yoke of the imaging apparatus. The variable friction disc is generally comprised of ring having a gap, with both sides of said gap having apertures therethrough such that a bolt may be inserted into said apertures and used to adjust the width of the gap, and the tension on the ring.