Patents by Inventor Sourav Roy CHOUDHURY

Sourav Roy CHOUDHURY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240139340
    Abstract: The disclosure relates, in some aspects, to compositions and methods for enhanced delivery of a transgene to the central nervous system (CNS) of a subject. In some embodiments, the transgene is delivered by recombinant AAV (rAAV). In some embodiments, the method of enhancing transgene delivery comprises administering a blood brain barrier (BBB)-crossing molecule (e.g., K16ApoE) and an rAAV comprising a transgene to a subject.
    Type: Application
    Filed: October 20, 2023
    Publication date: May 2, 2024
    Applicant: University of Massachusetts
    Inventors: Miguel Sena Esteves, Ana Rita Batista, Sourav Roy Choudhury
  • Publication number: 20230405014
    Abstract: Provided herein are methods for enhancing gene therapy in an individual by administering an IRAK degrader with the gene therapy to suppress innate immunity to the gene therapy. In some embodiments, the gene therapy uses an adeno-associated virus (AAV) vector, an adenovirus vector, a lentivirus vector, a Herpes simplex virus (HSV) vector or a lipid nanoparticle. Also provided herein are methods for selecting an individual for treatment with an IRAK degrader in combination with a gene therapy agent.
    Type: Application
    Filed: April 12, 2023
    Publication date: December 21, 2023
    Inventors: Sourav Roy CHOUDHURY, Mona MOTWANI, Christian MUELLER, John REED
  • Publication number: 20230407255
    Abstract: Provided herein are methods for determining the innate immunogenicity of a gene therapy agent in an individual. In particular, the methods involve the use of isolated dendritic cells to detect innate immunogenicity to a gene therapy agent. Exemplary gene therapy agents include adeno-associated virus (AAV) vectors, adenovirus vectors, lentivirus vectors, Herpes simplex virus (HSV) vectors or a lipid nanoparticles.
    Type: Application
    Filed: April 12, 2023
    Publication date: December 21, 2023
    Inventors: Sourav Roy CHOUDHURY, Mona MOTWANI
  • Publication number: 20230405151
    Abstract: Provided herein are methods for enhancing gene therapy in an individual by administering an IRAK modulator (e.g., an IRAK-4 degrader) with the gene therapy to suppress innate immunity to the gene therapy. In some embodiments, the gene therapy uses an adeno-associated virus (AAV) vector, an adenovirus vector, a lentivirus vector, a Herpes simplex virus (HSV) vector or a lipid nanoparticle. Also provided herein are methods for selecting an individual for treatment with an IRAK modulator in combination with a gene therapy agent.
    Type: Application
    Filed: April 12, 2023
    Publication date: December 21, 2023
    Inventors: Sourav Roy CHOUDHURY, Mona MOTWANI, Christian MUELLER, John REED
  • Patent number: 11826433
    Abstract: The disclosure relates, in some aspects, to compositions and methods for enhanced delivery of a transgene to the central nervous system (CNS) of a subject. In some embodiments, the transgene is delivered by recombinant AAV (rAAV). In some embodiments, the method of enhancing transgene delivery comprises administering a blood brain barrier (BBB)-crossing molecule (e.g., K16ApoE) and an rAAV comprising a transgene to a subject.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: November 28, 2023
    Assignee: University of Massachusetts
    Inventors: Miguel Sena Esteves, Ana Rita Batista, Sourav Roy Choudhury
  • Publication number: 20230067741
    Abstract: The disclosure relates, in some aspects, to adeno-associated virus capsid proteins isolated from an in vivo library and recombinant adeno-associated viruses (rAAVs) comprising the same. In some aspects, the disclosure relates to isolated nucleic acids encoding AAV capsid proteins isolated from an in vivo library. In some embodiments, rAAVs and compositions described by the disclosure are useful for delivery of one or more transgenes to the muscle-tissue of a subject.
    Type: Application
    Filed: September 7, 2022
    Publication date: March 2, 2023
    Applicants: University of Massachusetts, The Johns Hopkins University, Kennedy Krieger Institute, Inc.
    Inventors: Miguel Sena Esteves, Sourav Roy Choudhury, Kathryn Rae Wagner, Jennifer Gifford Green, Ana Rita Batista
  • Patent number: 11472848
    Abstract: The disclosure relates, in some aspects, to adeno-associated vims capsid proteins isolated from an in vivo library and recombinant adeno-associated viruses (rAAVs) comprising the same. In some aspects, the disclosure relates to isolated nucleic acids encoding AAV capsid proteins isolated from an in vivo library. In some embodiments, rAAVs and compositions described by the disclosure are useful for delivery of one or more transgenes to the muscle-tissue of a subject.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: October 18, 2022
    Assignees: University of Massachusetts, The Johns Hopkins University, Kennedy Krieger Institute, Inc.
    Inventors: Miguel Sena Esteves, Sourav Roy Choudhury, Kathryn Rae Wagner, Jennifer Gifford Green, Ana Rita Batista
  • Publication number: 20210324044
    Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
    Type: Application
    Filed: April 22, 2021
    Publication date: October 21, 2021
    Applicant: University of Massachusetts
    Inventors: Miguel Sena Esteves, Sourav Roy Choudhury
  • Publication number: 20210238233
    Abstract: The disclosure relates, in some aspects, to adeno-associated vims capsid proteins isolated from an in vivo library and recombinant adeno-associated viruses (rAAVs) comprising the same. In some aspects, the disclosure relates to isolated nucleic acids encoding AAV capsid proteins isolated from an in vivo library. In some embodiments, rAAVs and compositions described by the disclosure are useful for delivery of one or more transgenes to the muscle-tissue of a subject.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 5, 2021
    Applicants: University of Massachusetts, The Johns Hopkins University, Kennedy Krieger Institute, Inc.
    Inventors: Miguel Sena Esteves, Sourav Roy Choudhury, Kathryn Rae Wagner, Jennifer Gifford Green, Ana Rita Batista
  • Patent number: 11014976
    Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: May 25, 2021
    Assignee: University of Massachusetts
    Inventors: Miguel Sena Esteves, Sourav Roy Choudhury
  • Publication number: 20200354714
    Abstract: Aspects of the disclosure relate to barcoded chimeric adeno-associated virus (AAV) capsid libraries, chimeric capsids and related recombinant AAVs (rAAVs) identified using the libraries. Specifically, the chimeric AAV capsid libraries comprise a plurality of nucleic adds encoding AAV capsid proteins, wherein each nucleic acid (i) encodes a unique AAV capsid protein having distinct polypeptide regions of greater than six amino acids in length that are derived from at least two different AAV serotypes, and (ii) comprises a unique barcode sequence. Further disclosed are methods of preparing an AAV library and identifying AAV capsids tropic for a target tissue.
    Type: Application
    Filed: May 21, 2020
    Publication date: November 12, 2020
    Applicant: University of Massachusetts
    Inventors: Miguel Sena Esteves, Sourav Roy Choudhury
  • Patent number: 10711270
    Abstract: Aspects of the disclosure relate to barcoded chimeric adeno-associated virus (AAV) capsid libraries, chimeric capsids and related recombinant AAVs (rAAVs) identified using the libraries. Specifically, the chimeric AAV capsid libraries comprise a plurality of nucleic adds encoding AAV capsid proteins, wherein each nucleic acid (i) encodes a unique AAV capsid protein having distinct polypeptide regions of greater than six amino acids in length that are derived from at least two different AAV serotypes, and (ii) comprises a unique barcode sequence. Further disclosed are methods of preparing an AAV library and identifying AAV capsids tropic for a target tissue.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: July 14, 2020
    Assignee: University of Massachusetts
    Inventors: Miguel Sena Esteves, Sourav Roy Choudhury
  • Publication number: 20190389934
    Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
    Type: Application
    Filed: June 25, 2019
    Publication date: December 26, 2019
    Applicant: University of Massachusetts
    Inventors: Miguel Sena Esteves, Sourav Roy Choudhury
  • Patent number: 10370432
    Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: August 6, 2019
    Assignee: University of Massachusetts
    Inventors: Miguel Sena Esteves, Sourav Roy Choudhury
  • Publication number: 20190038773
    Abstract: The disclosure relates, in some aspects, to compositions and methods for enhanced delivery of a transgene to the central nervous system (CNS) of a subject. In some embodiments, the transgene is delivered by recombinant AAV (rAAV). In some embodiments, the method of enhancing transgene delivery comprises administering a blood brain barrier (BBB)-crossing molecule (e.g., K16ApoE) and an rAAV comprising a transgene to a subject.
    Type: Application
    Filed: February 2, 2017
    Publication date: February 7, 2019
    Applicant: University of Massachusetts
    Inventors: Miguel Sena Esteves, Ana Rita Batista, Sourav Roy Choudhury
  • Publication number: 20180265571
    Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
    Type: Application
    Filed: October 2, 2015
    Publication date: September 20, 2018
    Applicant: University of Massachusetts
    Inventors: Miguel Sena ESTEVES, Sourav Roy CHOUDHURY
  • Publication number: 20180265863
    Abstract: Aspects of the disclosure relate to barcoded chimeric adeno-associated virus (AAV) capsid libraries, chimeric capsids and related recombinant AAVs (rAAVs) identified using the libraries. Spedfically, the chimeric AAV capsid libraries comprise a plurality of nucleic adds encoding AAV capsid proteins, wherein each nucleic acid (i) encodes a unique AAV capsid protein having distinct polypeptide regions of greater than six amino acids in length that are derived from at least two different AAV serotypes, and (ii) comprises a unique barcode sequence. Further disdosed are methods of preparing an AAV library and identifying AAV capsids tropic for a target tissue.
    Type: Application
    Filed: October 2, 2015
    Publication date: September 20, 2018
    Applicant: University of Massachusetts
    Inventors: Miguel Sena ESTEVES, Sourav Roy CHOUDHURY