Abstract: Many disorders wherein inflammation is a hallmark such as rheumatoid arthritis, sepsis, or cancer, are chronic and impose a significant burden on family and society due to their high morbidity and mortality. Each year the United States government spends $2.6T to treat chronic Inflammatory diseases, which are linked to 70% of the deaths every year. Protein therapeutics, such as anti-TNF? antibodies that selectively block the TNF? cascade, have become the mainstay therapy for the management of chronic inflammatory diseases. Despite the promise of these early studies, concerns about the side effects of these protein drugs, including induction of auto-antibodies and immuno-suppression, may limit the applications to disease treatments. Thus, there is a need to develop new drugs and delivery systems for the prevention and treatment of inflammatory diseases. The present invention relates to extracellular vesicle composition, system, and methods for treating Toll-like receptor-driven inflammatory disease.