Patents by Inventor Souvik Modi

Souvik Modi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of multiplexing DNA sensors and localizing DNA sensor
    Patent number: 10443089
    Abstract: The present disclosure relates to a method of multiplexing DNA sensors and optionally measuring pH in cell, a method of localizing DNA sensor in Golgi Network of scFv-Furin expressing cell and a method of identifying optimal location of fluorophore pair on the DNA sensor for multiplexing DNA sensors. The DNA sensors of the present disclosure follow independent cellular pathways and do not interact with or compromise functionality of another DNA sensor.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: October 15, 2019
    Assignee: National Centre For Biological Sciences (NCBS-TIFR)
    Inventors: Yamuna Krishnan, Souvik Modi, Sunaina Surana
  • Nucleic acid assembly, vector, cell, methods and kit thereof
    Patent number: 9404123
    Abstract: The present disclosure relates to a nucleic acid assembly (NAA), comprising sensor domain and handle domain; an assembly interfaceable motif (AIM) sequence optionally along with intracellular targeting motif (ITM) sequence; and an AIM-NAA complex. It also relates to a vector comprising assembly interfaceable motif sequence optionally along with intracellular targeting motif sequence and a cell comprising the vector. Further, the instant disclosure also provides a method to obtain the nucleic acid assembly, method of intracellular targeting and kit thereof.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: August 2, 2016
    Assignee: National Centre for Biological Sciences
    Inventors: Yamuna Krishnan, Souvik Modi
  • Intracellular pH sensor using nucleic acid assemblies
    Patent number: 9250252
    Abstract: Disclosed are nucleic acid-based sensors for measuring the pH of a sample, including cells, regions thereof, and whole organisms. The sensor includes an I-switch that is triggered by protons, and which functions as a FRET-based pH sensor inside living cells and organisms. Also disclosed are compositions and methods for measuring the pH of a specific region of a cell, such as vesicles, the nucleus, mitochondrial matrix, or the Golgi lumen.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: February 2, 2016
    Assignee: NATIONAL CENTRE FOR BIOLOGICAL SCIENCES
    Inventors: Yamuna Krishnan, Satyajit Mayor, Souvik Modi
  • METHODS OF MULTIPLEXING DNA SENSORS AND LOCALIZING DNA SENSOR
    Publication number: 20160002713
    Abstract: The present disclosure relates to a method of multiplexing DNA sensors and optionally measuring pH in cell, a method of localizing DNA sensor in Golgi Network of scFv-Furin expressing cell and a method of identifying optimal location of fluorophore pair on the DNA sensor for multiplexing DNA sensors. The DNA sensors of the present disclosure follow independent cellular pathways and do not interact with or compromise functionality of another DNA sensor.
    Type: Application
    Filed: February 25, 2014
    Publication date: January 7, 2016
    Inventors: Yamuna Krishnan, Souvik Modi, Sunaina Surana
  • NUCLEIC ACID ASSEMBLY, VECTOR, CELL, METHODS AND KIT THEREOF
    Publication number: 20140335568
    Abstract: The present disclosure relates to a nucleic acid assembly (NAA), comprising sensor domain and handle domain; an assembly interfaceable motif (AIM) sequence optionally along with intracellular targeting motif (ITM) sequence; and an AIM-NAA complex. It also relates to a vector comprising assembly interfaceable motif sequence optionally along with intracellular targeting motif sequence and a cell comprising the vector. Further, the instant disclosure also provides a method to obtain the nucleic acid assembly, method of intracellular targeting and kit thereof.
    Type: Application
    Filed: October 11, 2012
    Publication date: November 13, 2014
    Applicant: NATIONAL CENTRE FOR BIOLOGICAL SCIENCES
    Inventors: Yamuna Krishnan, Souvik Modi
  • INTRACELLULAR PH SENSOR USING NUCLEIC ACID ASSEMBLIES
    Publication number: 20100304370
    Abstract: Disclosed are nucleic acid-based sensors for measuring the pH of a sample, including cells, regions thereof, and whole organisms. The sensor includes an I-switch that is triggered by protons, and which functions as a FRET-based pH sensor inside living cells and organisms. Also disclosed are compositions and methods for measuring the pH of a specific region of a cell, such as vesicles, the nucleus, mitochondrial matrix, or the Golgi lumen.
    Type: Application
    Filed: May 29, 2009
    Publication date: December 2, 2010
    Inventors: Yamuna Krishnan, Satyajit Mayor, Souvik Modi