Patents by Inventor Souvik Rakshit

Souvik Rakshit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Scalable synthesis of reduced toxicity derivative of amphotericin B
    Patent number: 10683318
    Abstract: Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2?epiAmB, an efficacious and reduced-toxicity derivative of amphotericin B (AmB), beginning from AmB. Also provided are various compounds corresponding to intermediates in accordance with the series of methods.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: June 16, 2020
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, Brice E. Uno, Souvik Rakshit
  • SCALABLE SYNTHESIS OF REDUCED TOXICITY DERIVATIVE OF AMPHOTERICIN B
    Publication number: 20190127412
    Abstract: Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2?epiAmB, an efficacious and reduced-toxicity derivative of amphotericin B (AmB), beginning from AmB. Also provided are various compounds corresponding to intermediates in accordance with the series of methods.
    Type: Application
    Filed: October 1, 2018
    Publication date: May 2, 2019
    Inventors: Martin D. BURKE, Brice E. Uno, Souvik Rakshit
  • Scalable synthesis of reduced toxicity derivative of amphotericin B
    Patent number: 10087206
    Abstract: Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2?epiAmB, an efficacious and reduced-toxicity derivative of amphotericin B (AmB), beginning from AmB. Also provided are various compounds corresponding to intermediates in accordance with the series of methods.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: October 2, 2018
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, Brice E. Uno, Souvik Rakshit
  • Small molecule inducers of GDNF as potential new therapeutics for neuropsychiatric disorders
    Patent number: 9988377
    Abstract: This invention provides a compound having the structure wherein A is a ring structure, with or without substitution; Z is present or absent and when present is wherein n is 0, 1, 2, 3, or 4; Y is —(CR11R12)—, —NH(CR11R12)—, or —O(CR11R12)—, wherein R11 and R12 are each hydrogen or combine to form a carbonyl; R1, R2, R3, R4, R5 and R6 are independently H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroaryl, hydroxyl, amino, ester or amide; ? represents a bond, which is present or absent and when ? is present, then R7 and R8 are absent; R7 and R8 are present when ? is absent and are independently H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroaryl, hydroxyl, amino, ester, amide or R5 and R7 combine to form a carbonyl or R6 and R8 combine to form a carbonyl; R9 and R10 are each hydrogen o
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: June 5, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Dalibor Sames, Xiaoguang Li, Shu Li, Andrew Kruegel, Richard Karpowicz, Ignacio Carrera, Souvik Rakshit
  • SCALABLE SYNTHESIS OF REDUCED TOXICITY DERIVATIVE OF AMPHOTERICIN B
    Publication number: 20170233427
    Abstract: Disclosed is a simplified, readily scalable series of individual methods that collectively constitute a method for the synthesis of C2?epiAmB, an efficacious and reduced-toxicity derivative of amphotericin B (AmB), beginning from AmB. Also provided are various compounds corresponding to intermediates in accordance with the series of methods.
    Type: Application
    Filed: October 16, 2015
    Publication date: August 17, 2017
    Inventors: Martin D. Burke, Brice E. Uno, Souvik Rakshit
  • SMALL MOLECULE INDUCERS OF GDNF AS POTENTIAL NEW THERAPEUTICS FOR NEUROPSYCHIATRIC DISORDERS
    Publication number: 20150056699
    Abstract: This invention provides a compound having the structure wherein A is a ring structure, with or without substitution; Z is present or absent and when present is wherein n is 0, 1, 2, 3, or 4; Y is —(CR11R12)—, —NH(CR11R12)—, or —O(CR11R12)—, wherein R11 and R12 are each hydrogen or combine to form a carbonyl; R1, R2, R3, R4, R5 and R6 are independently H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroaryl, hydroxyl, amino, ester or amide; ? represents a bond, which is present or absent and when ? is present, then R7 and R8 are absent; R7 and R8 are present when ? is absent and are independently H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroaryl, hydroxyl, amino, ester, amide or R5 and R7 combine to form a carbonyl or R6 and R8 combine to form a carbonyl; R9 and R10 are each hydrogen o
    Type: Application
    Filed: August 24, 2012
    Publication date: February 26, 2015
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Dalibor Sames, Xiaoguang Li, Shu Li, Andrew Kruegel, Richard Karpowicz, Ignacio Carrera, Souvik Rakshit