Patents by Inventor Spandan Chennamadhavuni

Spandan Chennamadhavuni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MALT1 inhibitors and uses thereof
    Patent number: 10711036
    Abstract: Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, MALT lymphoma), benign neoplasm, a disease associated with angiogenesis, an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: July 14, 2020
    Assignees: Cornell University, Dana-Farber Cancer Institute, Inc., Children's Medical Center Corporation
    Inventors: Nathanael S. Gray, David A. Scott, John Hatcher, Spandan Chennamadhavuni, Ari M. Melnick, Lorena Fontan Gabas, Hao Wu, Qi Qiao, Guangyan Du
  • MALT1 INHIBITORS AND USES THEREOF
    Publication number: 20190389904
    Abstract: Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, MALT, lymphoma), benign neoplasm, a disease associated with angiogenesis, an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).
    Type: Application
    Filed: August 26, 2016
    Publication date: December 26, 2019
    Applicants: Cornell University, Dana-Farber Cancer Institute, Inc., Children's Medical Center Corporation
    Inventors: Nathanael S. Gray, David A. Scott, John Hatcher, Spandan Chennamadhavuni, Ari M. Melnick, Lorena Fontan Gabas, Hao Wu, Qi Qiao, Guangyan Du
  • Cyclopropyl derivatives and methods of use
    Patent number: 10207984
    Abstract: The disclosure relates to cyclopropyl derivatives and methods of use. In some embodiments, the disclosure relates to methods of managing medical disorders with pharmaceutical compositions disclosed herein administered to subject in need thereof. In certain embodiments, the disclosure relates to methods of managing mental disorders, mood disorders, pain, and fibromyalgia and related conditions with pharmaceutical compositions disclosed herein.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: February 19, 2019
    Assignees: Emory University, Wake Forest University Health Services
    Inventors: Huw M. L. Davies, Spandan Chennamadhavuni, Thomas J. Martin, Steven R. Childers
  • TAK1 kinase inhibitors, compositions, and uses related thereto
    Patent number: 10093609
    Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a compound of formula I, and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula I to a subject in need thereof.
    Type: Grant
    Filed: September 4, 2017
    Date of Patent: October 9, 2018
    Assignee: Emory University
    Inventors: Huw M. L. Davies, Spandan Chennamadhavuni, Andrei Bakin
  • MALT1 INHIBITORS AND USES THEREOF
    Publication number: 20180251489
    Abstract: Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, MALT, lymphoma), benign neoplasm, a disease associated with angiogenesis, an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).
    Type: Application
    Filed: August 26, 2016
    Publication date: September 6, 2018
    Applicants: Cornell University Cornell Center for Technology Enterprise & Commercialization (CCTEC), Dana-Farber Cancer Institute, Inc., Children's Medical Center Corporation
    Inventors: Nathanael S. Gray, David A Scott, John Hatcher, Spandan Chennamadhavuni, Ari M. Melnick, Lorena Fontan Gabas, Hao Wu, Qi Qiao, Guangyan Du
  • TAK1 Kinase Inhibitors, Compositions, and Uses Related Thereto
    Publication number: 20170369417
    Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a compound of formula I, and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula I to a subject in need thereof.
    Type: Application
    Filed: September 4, 2017
    Publication date: December 28, 2017
    Inventors: Huw M. L. Davies, Spandan Chennamadhavuni, Andrei Bakin
  • TAK1 kinase inhibitors, compositions, and used related thereto
    Patent number: 9751825
    Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula (I), pharmaceutical compositions having a compound of formula (I), and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula (I) to a subject in need thereof.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: September 5, 2017
    Assignee: Emory University
    Inventors: Huw M. L. Davies, Spandan Chennamadhavuni, Andrei Bakin
  • Cyclopropyl Derivatives and Methods of Use
    Publication number: 20160244403
    Abstract: The disclosure relates to cyclopropyl derivatives and methods of use. In some embodiments, the disclosure relates to methods of managing medical disorders with pharmaceutical compositions disclosed herein administered to subject in need thereof. In certain embodiments, the disclosure relates to methods of managing mental disorders, mood disorders, pain, and fibromyalgia and related conditions with pharmaceutical compositions disclosed herein.
    Type: Application
    Filed: May 3, 2016
    Publication date: August 25, 2016
    Inventors: Huw M. Davies, Spandan Chennamadhavuni, Thomas J. Martin, Steven R. Childers
  • TAK1 KINASE INHIBITORS, COMPOSITIONS, AND USED RELATED THERETO
    Publication number: 20140249199
    Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula (I), pharmaceutical compositions having a compound of formula (I), and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula (I) to a subject in need thereof.
    Type: Application
    Filed: July 19, 2012
    Publication date: September 4, 2014
    Applicants: HEALTH RESEARCH, INC., EMORY UNIVERSITY
    Inventors: Huw M. L. Davies, Spandan Chennamadhavuni, Andrei Bakin
  • CYCLOPROPYL DERIVATIVES AND METHODS OF USE
    Publication number: 20140045936
    Abstract: The disclosure relates to cyclopropyl derivatives and methods of use. In some embodiments, the disclosure relates to methods of managing medical disorders with pharmaceutical compositions disclosed herein administered to subject in need thereof. In certain embodiments, the disclosure relates to methods of managing mental disorders, mood disorders, pain, and fibromyalgia and related conditions with pharmaceutical compositions disclosed herein.
    Type: Application
    Filed: April 13, 2012
    Publication date: February 13, 2014
    Applicants: WAKE FOREST UNIVERSITY HEALTH SCIENCES, EMORY UNIVERSITY
    Inventors: Huw M. Davies, Spandan Chennamadhavuni, Thomas J. Martin, Steven R. Childrens