Abstract: Delivery systems for expandable and stented implants include adjustable tensioning members that control the expansion of the implant along the length of the implant. The tensioning members are wound onto one or more rotors located on the distal segment of the delivery system, which are rotated to unwind the tensioning members and incrementally expand the implant. Positioning mechanisms are also provided to adjust the position and orientation of the implant during delivery.

Abstract: Delivery systems for expandable and stented implants include adjustable tensioning members that control the expansion of the implant along the length of the implant. The tensioning members are wound onto one or more rotors located on the distal segment of the delivery system, which are rotated to unwind the tensioning members and incrementally expand the implant. Positioning mechanisms are also provided to adjust the position and orientation of the implant during delivery.

Abstract: A delivery device for cardiac valve repair implants includes a delivery catheter and an extension member protruding from a distal end of the delivery catheter. The delivery device further includes a control arm assembly having pairs of control arms. Each pair includes a proximal control arm drivable from a handle assembly of the delivery device and a distal arm coupled to a distal end of the proximal control arm and a distal end of the extension member. Proximally driving each of the proximal control arms of the control arm assembly results in expansion of the control arm assembly and corresponding expansion of a cardiac valve repair implant coupled to the control arm assembly.

Abstract: Delivery systems for expandable and stented implants include adjustable tensioning members that control the expansion of the implant along the length of the implant. The tensioning members are wound onto one or more rotors located on the distal segment of the delivery system, which are rotated to unwind the tensioning members and incrementally expand the implant. Positioning mechanisms are also provided to adjust the position and orientation of the implant during delivery.

Abstract: A replacement heart valve comprises a unibody, folded, double-wall stent, with a stent cover and a leaflet valve attached to the inner lumen of the stent. The heart valve is delivered using a multi-pulley, suture-based stent restraint assembly provided by fixed guide openings or structures along the distal end of the delivery system that independently permits expansion of the distal and proximal ends of the outer wall of the stent, and control of the inner wall expansion simultaneously with or separately from the expansion of the outer wall.

Abstract: A delivery device for cardiac valve repair implants includes a delivery catheter and an extension member protruding from a distal end of the delivery catheter. The delivery device further includes a control arm assembly having pairs of control arms. Each pair includes a proximal control arm drivable from a handle assembly of the delivery device and a distal arm coupled to a distal end of the proximal control arm and a distal end of the extension member. Proximally driving each of the proximal control arms of the control arm assembly results in expansion of the control arm assembly and corresponding expansion of a cardiac valve repair implant coupled to the control arm assembly.

Abstract: A replacement heart valve comprises a unibody, folded, double-wall stent, with a stent cover and a leaflet valve attached to the inner lumen of the stent. The heart valve is delivered using a multi-pulley, suture-based stent restraint assembly provided by fixed guide openings or structures along the distal end of the delivery system that independently permits expansion of the distal and proximal ends of the outer wall of the stent, and control of the inner wall expansion simultaneously with or separately from the expansion of the outer wall.

Abstract: A replacement heart valve comprises one or more stent frame features, including inset barbs, ring attachment structures or attachment tabs.

Abstract: A replacement heart valve comprises a unibody, folded, double-wall stent, with a stent cover and a leaflet valve attached to the inner lumen of the stent. The heart valve is delivered using a multi-pulley, suture-based stent restraint assembly provided by fixed guide openings or structures along the distal end of the delivery system that independently permits expansion of the distal and proximal ends of the outer wall of the stent, and control of the inner wall expansion simultaneously with or separately from the expansion of the outer wall.

Abstract: Delivery systems for expandable and stented implants include adjustable tensioning members that control the expansion of the implant along the length of the implant. The tensioning members are wound onto one or more rotors located on the distal segment of the delivery system, which are rotated to unwind the tensioning members and incrementally expand the implant. Positioning mechanisms are also provided to adjust the position and orientation of the implant during delivery.

Abstract: A valve implant includes an occlusive assembly and a frame coupled to the occlusive assembly. The frame transitions from a collapsed state to an expanded state about a central longitudinal axis and transitioning from the collapsed state to the expanded state causes a proximal end of the frame to expand radially outward from the central longitudinal axis. The valve implant further includes an outer sheet supported on a proximal portion of the frame. The occlusive assembly is supported on a distal portion of the frame such that the inner sheet extends about the central longitudinal axis and an annular opening is defined between the outer sheet and the inner sheet when the frame is in the expanded state.

Abstract: A cardiac valve repair implant, wherein the implant includes a central occluder, and frame and a thin sheet. The central occluder includes a central longitudinal axis. The frame extends proximally from the central occluder and is centered about and forms a circumference around the central longitudinal axis of the central occluder. The frame self-biases from a collapsed state to an expanded state. A proximal end of the frame projects proximally when the frame is in the collapsed state. The proximal end of the frame projects radially outward away from the central longitudinal axis of the central occluder when the frame is in the expanded state. The thin sheet is supported on a proximal portion of the frame. When the frame is in the expanded state, the thin sheet forms an annular surface defining an inner circular opening centered about the central longitudinal axis of the central occluder.

Abstract: Delivery systems for expandable and stented implants include adjustable tensioning members that control the expansion of the implant along the length of the implant. The tensioning members are wound onto one or more rotors located on the distal segment of the delivery system, which are rotated to unwind the tensioning members and incrementally expand the implant. Positioning mechanisms are also provided to adjust the position and orientation of the implant during delivery.

Abstract: A replacement heart valve comprises a unibody, folded, double-wall stent, with a stent cover and a leaflet valve attached to the inner lumen of the stent. The heart valve is delivered using a multi-pulley, suture-based stent restraint assembly provided by fixed guide openings or structures along the distal end of the delivery system that independently permits expansion of the distal and proximal ends of the outer wall of the stent, and control of the inner wall expansion simultaneously with or separately from the expansion of the outer wall.

Abstract: A valve replacement implant may include an expandable anchor member having a proximal end and a distal end, the anchor member being actuatable between a delivery configuration and a deployed configuration. A plurality of locking mechanisms may be configured to secure the anchor member in the deployed configuration. Each locking mechanism may include an axially movable post including a leg portion extending inwardly therefrom, and a receiving portion fixed to the anchor member, the receiving portion being configured to slidably receive the post. A plurality of valve leaflets may be disposed within a central lumen of the anchor member, the plurality of valve leaflets being secured to the leg portions of the plurality of locking mechanisms. The plurality of locking mechanisms may be releasably attached to a delivery device.

Abstract: A prosthetic heart valve includes a plurality of leaflets and an expandable member including one or more braided wires with a first set of wire segments extended helically in a first direction and a second set of wire segments extended helically in a second direction such that each wire segment of the first set intersects a plurality of wire segments from the second set at a plurality of intersection points. The one or more braided wires can have crowns where the wire segments of the first set connect to wire segments of the second set. The heart valve can include a tubular seal secured to the plurality of leaflets and to the expandable member by a plurality of sutures. The sutures can include cross stitches formed around both a wire segment of the first set and a wire segment of the second set at one of the intersection points.

Abstract: A prosthetic heart valve includes a plurality of leaflets and an expandable member including one or more braided wires with a first set of wire segments extended helically in a first direction and a second set of wire segments extended helically in a second direction such that each wire segment of the first set intersects a plurality of wire segments from the second set at a plurality of intersection points. The one or more braided wires can have crowns where the wire segments of the first set connect to wire segments of the second set. The heart valve can include a tubular seal secured to the plurality of leaflets and to the expandable member by a plurality of sutures. The sutures can include cross stitches formed around both a wire segment of the first set and a wire segment of the second set at one of the intersection points.

Abstract: A valve replacement implant may include an expandable anchor member having a proximal end and a distal end, the anchor member being actuatable between a delivery configuration and a deployed configuration. A plurality of locking mechanisms may be configured to secure the anchor member in the deployed configuration. Each locking mechanism may include an axially movable post including a leg portion extending inwardly therefrom, and a receiving portion fixed to the anchor member, the receiving portion being configured to slidably receive the post. A plurality of valve leaflets may be disposed within a central lumen of the anchor member, the plurality of valve leaflets being secured to the leg portions of the plurality of locking mechanisms. The plurality of locking mechanisms may be releasably attached to a delivery device.