Patents by Inventor Spencer D. Kimball
Spencer D. Kimball has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9193729Abstract: This disclosure describes a novel compounds and pharmaceutical compositions for inhibiting the TRPA1 ion channel and/or medical conditions related to TRPA1, such as pain.Type: GrantFiled: March 15, 2013Date of Patent: November 24, 2015Assignee: Cubist Pharmaceuticals, Inc.Inventors: Chester A. Metcalf, III, Yu Gui Gu, Spencer D. Kimball, Qingy Li, Blaise S. Lippa, Dominic Ryan, Xinyuan Wu, Dong Zou
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Publication number: 20130274273Abstract: This disclosure describes a novel compounds and pharmaceutical compositions for inhibiting the TRPA1 ion channel and/or medical conditions related to TRPA1, such as pain.Type: ApplicationFiled: March 15, 2013Publication date: October 17, 2013Applicant: Cubist Pharmaceuticals, Inc.Inventors: Chester A. Metcalf, III, Yu Gui Gu, Spencer D. Kimball, Qingy Li, Blaise S. Lippa, Dominic Ryan, Xinyuan Wu, Dong Zou
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Patent number: 7300949Abstract: This invention concerns novel thiazolopyrazole compounds and compositions comprising them. Methods of using these compounds for the treatment, prevention and management of various diseases and disorders are also encompassed by the invention.Type: GrantFiled: March 31, 2005Date of Patent: November 27, 2007Assignee: Lexicon Pharmaceuticals, Inc.Inventors: Joseph Barbosa, Cynthia A. Fink, Spencer D. Kimball, Hartmuth Kolb, Zhi-Cai Shi, Ashok R. Tunoori
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Patent number: 6534536Abstract: Alkylsulfonamido heterocyclic thrombin inhibitors are provided which have the structure wherein G is wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; R is hydrogen, hydroxyalkyl, aminoalkyl, alkyl, cycloalkyl, amidoalkyl, arylalkyl, alkenyl, aryl, alkynyl, arylalkoxyalkyl, or an amino acid side chain; R1 and R2 are independently hydrogen, lower alkyl, cycloalkyl, aryl, hydroxy, alkoxy, oxo, thioketal, thioalkyl, thioaryl, amino or alkylamino; or R1 and R2 can be taken together with the carbons to which they are attached to form a cycloalkyl, aryl or heteroaryl ring.Type: GrantFiled: March 16, 1994Date of Patent: March 18, 2003Assignee: Bristol-Myers Squibb CompanyInventors: Spencer D. Kimball, Jagabandhu Das, Wan Fang Lau
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Patent number: 5741792Abstract: Heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein n, R, R.sup.1, R.sup.2, R.sup.3, G, G.sub.x, R.sup.6 ', Ra, Xa, R.sup.6, Rb, R.sub.3, p, Q, A and R.sup.4 are as defined herein.Type: GrantFiled: November 8, 1995Date of Patent: April 21, 1998Assignee: Bristol-Myers Squibb CompanyInventors: Spencer D. Kimball, Jagabandhu Das, Wan Fang Lau, Steven E. Hall, Wen-Ching Han
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Patent number: 5741799Abstract: Heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein n, R, R.sup.1, R.sup.2, R.sup.3, G, G.sub.x, R.sup.6', Ra, Xa, R.sup.6, Rb, R.sub.3, p, Q, A and R.sup.4 are as defined herein.Type: GrantFiled: November 8, 1995Date of Patent: April 21, 1998Assignee: Bristol-Myers Squibb CompanyInventors: Spencer D. Kimball, Jagabandhu Das, Wan Fang Lau, Steven E. Hall, Wen-Ching Han
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Patent number: 5691356Abstract: Disubstituted heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein G is ##STR2## wherein n is 0, 1 or 2 or 3; m is 0, 1, 2 or 3; Y is NH or S; p is 0, 1 or 2, Q is a single bond or ##STR3## and Z, A, R, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are as defined herein.Type: GrantFiled: September 4, 1996Date of Patent: November 25, 1997Assignee: Bristol-Myers Squibb CompanyInventors: Jagabandhu Das, Spencer D. Kimball, Wan Fang Lau
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Patent number: 5583146Abstract: Heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein n, R, R.sup.1, R.sup.2, R.sup.3, G, G.sub.x, R.sup.6', Ra, Xa, R.sup.6, Rb, R.sub.3, p, Q, A and R.sup.4 are as defined herein.Type: GrantFiled: January 17, 1995Date of Patent: December 10, 1996Assignee: Bristol-Myers Squibb CompanyInventors: Spencer D. Kimball, Jagabandhu Das, Wan F. Lau, Steven E. Hall, Wen-Ching Han
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Patent number: 5561146Abstract: Thrombin inhibitors are provided which have the formula ##STR1## wherein Z is a thrombin inhibitor substructure containing distal and proximal binding site residues; andR.sup.1 is cyano, hydroxyl, alkoxy, amino, aminoalkyl or nitro.Type: GrantFiled: October 14, 1994Date of Patent: October 1, 1996Assignee: Bristol-Myers Squibb CompanyInventors: Kyoung S. Kim, Spencer D. Kimball, Jagabandhu Das, Edwin J. Iwanowicz, Wen-Ching Han
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Patent number: 5202330Abstract: Pyrimidine compounds of the formula ##STR1## wherein X is sulfur or oxygen, Y is R.sub.11 or --O--R.sub.1, and R.sub.4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents, particularly anti-hypertensive agents, due to their calcium entry blocking vasodilator activity.Type: GrantFiled: January 5, 1987Date of Patent: April 13, 1993Assignee: E. R. Squibb & Sons, Inc.Inventors: Karnail Atwal, George C. Rovnyak, Spencer D. Kimball
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Patent number: 5143915Abstract: A compound of the formula ##STR1## (symbols defined in the specification), its 3,4-dihydropyrimidine tautomer form and pharmaceutically acceptable salts thereof have calcium entry blocking activity. A process of preparation, pharmaceutical composition and method of using the compound to reduce blood pressure are also provided.Type: GrantFiled: July 25, 1990Date of Patent: September 1, 1992Assignee: E. R. Squibb & Sons, Inc.Inventors: George C. Rovnyak, Spencer D. Kimball
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Patent number: 5103006Abstract: Novel compounds of the formula ##STR1## wherein X is sulfur or oxygen, R.sub.2 is aryl or heterocyclo and R.sub.1 is as defined herein, are disclosed. Compounds of formula I possess calcium channel activating activity.Type: GrantFiled: August 21, 1990Date of Patent: April 7, 1992Assignee: E. R. Squibb & Sons, Inc.Inventors: George C. Rovnyak, Spencer D. Kimball
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Patent number: 4952692Abstract: Novel compounds of the formula ##STR1## exhibit calcium channel blocking activity and are useful as cardiovascular agents.Type: GrantFiled: April 4, 1989Date of Patent: August 28, 1990Assignee: E. R. Squibb & Sons, Inc.Inventors: John Krapcho, Joel C. Barrish, Spencer D. Kimball
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Patent number: 4946840Abstract: Vasodilating activity is exhibited by compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein X is --CH.sub.2 -- or --S--;R.sub.1 is ##STR2## or --O--Y.sub.3 ; R.sub.2 is heterocyclo or heteroaryl;R.sub.3 and R.sub.4 are each independently hydrogen, halogen, alkyl, alkoxy, aryloxy, arylalkoxy, arylalkyl, cyano, hydroxy, alkanoyloxy, ##STR3## fluoro-substituted alkoxy, fluoro-substituted alkyl, (cycloalkyl)alkoxy, --NO.sub.2, --NY.sub.10 Y.sub.11, --S(O).sub.k alkyl, --S(O).sub.k aryl ##STR4## n is 0, 1, 2 or 3; m is 0, 1, 2 or 3;k is 0, 1 or 2;Y.sub.1 and Y.sub.2 are each independently hydrogen or alkyl; or Y.sub.1 is hydrogen and Y.sub.2 is alkenyl, alkynyl, aryl, heteroaryl, or cycloalkyl; or Y.sub.1 and Y.sub.2, together with the carbon atom to which they are attached, are cycloalkyl;Y.sub.3 is hydrogen, alkyl, alkanoyl, alkenyl, arylcarbonyl, heteroarylcarbonyl, or ##STR5## Y.sub.8 and Y.sub.9 are each independently hydrogen, alkyl, aryl, or heteroaryl; or Y.sub.Type: GrantFiled: April 6, 1989Date of Patent: August 7, 1990Assignee: E. R. Squibb & Sons, Inc.Inventors: Joel C. Barrish, Spencer D. Kimball, John Krapcho
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Patent number: 4902684Abstract: Vasodilating activity is exhibited by compounds having the formula ##STR1## wherein X can be --S--or --CH.sub.2 --; andR.sub.2 is ##STR2##depending upon the definition of X.Type: GrantFiled: May 22, 1989Date of Patent: February 20, 1990Assignee: E. R. Squibb & Sons, Inc.Inventors: David M. Floyd, John T. Hunt, Spencer D. Kimball, John Krapcho, Jagabandhu Das, George C. Rovnyak, Joel C. Barrish
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Patent number: 4788010Abstract: Hypotensive activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sub.1 is hydrogen or alkyl;R.sub.2 and R.sub.3 are each independently phenyl, substituted phenyl, cycloalkyl, or R.sub.2 is hydrogen and R.sub.3 is heteroaryl;R.sub.4 and R.sub.5 are the same or different and each is hydrogen, hydroxy, alkoxy, alkanoyl or alkyl;R.sub.6 is hydrogen or alkyl; andn is 1, 2, 3 or 4; with the proviso that if R.sub.2 and R.sub.3 are each phenyl, at least one of R.sub.1, R.sub.4, R.sub.5 and R.sub.6 is other than hydrogen.Type: GrantFiled: April 24, 1985Date of Patent: November 29, 1988Assignee: E. R. Squibb & Sons, Inc.Inventors: David M. Floyd, Spencer D. Kimball, Steven Brandt
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Patent number: 4548751Abstract: Antibacterial activity is exhibited by 3-acylamino-2-azetidinones having in the 1-position a group of the formula ##STR1## or an ester of salt thereto, wherein R.sub.5 and R.sub.6 are the same or different and each is hydrogen, alkyl, phenyl or substituted phenyl.Type: GrantFiled: August 3, 1983Date of Patent: October 22, 1985Assignee: E. R. Squibb & Sons, Inc.Inventors: Spencer D. Kimball, David Kronenthal, William H. Koster