Patents by Inventor Spencer Drummond, Jr.

Spencer Drummond, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sequential benzylic oxidations of the naloxone ring system
    Patent number: 6166211
    Abstract: The present invention pertains to a process for the preparation of the 10-keto analogs of morphinan compounds. In the case of compounds having a 3-hydroxyl group, the 3-methyl ether protected analog is synthesized by selective phenolic methylation in the presence of the basic amino group. When nalbuphine, morphine, or codeine is used as the starting material, the additional 6-hydroxyl group is protected using acetylation. The protected analog is selectively oxidized by treatment with cerium ammonium nitrate to provide the 10-(S)-hydroxy adduct. The 10-(S)-hydroxy adduct is further oxidized to the 10-keto analog. Any protecting groups that were added prior to oxidation are cleaved subsequent to oxidation to form the desired 10-ketomorphinan.
    Type: Grant
    Filed: March 7, 2000
    Date of Patent: December 26, 2000
    Assignee: Endo Pharmaceuticals, Inc.
    Inventors: Gary A. Cain, Spencer Drummond, Jr.
  • Antihypercholesterolemic bis-trifluoromethyl-substituted imidazolines and derivatives thereof
    Patent number: 5428041
    Abstract: Provided are bis-trifluoromethyl-substituted imidazolines as inhibitors of Acyl-CoA:Cholesterol Acyltransferase (ACAT), processes for their preparation, pharmaceutical compositions, and therapeutic methods for their use as antihypercholesterolemic or antiatherosclerotic agents.
    Type: Grant
    Filed: March 4, 1992
    Date of Patent: June 27, 1995
    Assignee: The Du Pont Merck Pharmaceutical Company
    Inventors: Jeffrey T. Billheimer, George A. Boswell, Jr., Indawati De Lucca, Spencer Drummond, Jr., Peter J. Gillies, James M. Trzaskos