Patents by Inventor Spencer Glantz
Spencer Glantz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230295706Abstract: Aspects of the disclosure relate to compositions and methods for amplifying and/or detecting one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens) in a biological sample obtained from a subject. In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. In some embodiments, the methods comprise isothermal amplification of a target nucleic acid and subsequent detection of the amplification products.Type: ApplicationFiled: January 12, 2023Publication date: September 21, 2023Applicants: Detect, Inc., Board of Regents, The University of Texas SystemInventors: Spencer Glantz, Jonathan M. Rothberg, Xinghua Shi, Benjamin Rosenbluth, Jaymin Patel, William A. Hansen, Jonathan Naccache, Hope Kronman, Henry Kemble, Caixia Lv, Andrew Ellington, Sanchita Bhadra
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Publication number: 20230220465Abstract: Aspects of the disclosure relate to compositions and methods for amplifying and/or detecting one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens) in a biological sample obtained from a subject. In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. In some embodiments, the methods comprise isothermal amplification of a target nucleic acid and subsequent detection of the amplification products.Type: ApplicationFiled: January 12, 2023Publication date: July 13, 2023Applicant: Detect, Inc.Inventors: Spencer Glantz, Jonathan M. Rothberg, Xinghua Shi, Benjamin Rosenbluth, Jaymin Patel, William A. Hansen, Jonathan Naccache, Hope Kronman, Henry Kemble, Caixia Lv
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Publication number: 20220305496Abstract: Aspects of the disclosure relate to devices and methods for amplifying and/or detecting one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens) in a biological sample obtained from a subject, wherein the biological sample is combined with a diluent and/or matrix resolving agent.Type: ApplicationFiled: March 16, 2022Publication date: September 29, 2022Inventors: Spencer Glantz, Henry Kemble, William A. Hansen, Sarai Meyer, Andrew Le, Eleanor Rose Henn, Molly Grun, Maya Overton, Rabib Shahab Chaudhury
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Publication number: 20220139496Abstract: The present disclosure provides methods, compositions, kits, and systems for identifying recombinases and cognate site-specific recombinase recognition sites as well as method for using the identified recombinase/recognition site pairs.Type: ApplicationFiled: November 18, 2021Publication date: May 5, 2022Applicant: Protein Evolution Inc.Inventors: Henry Kemble, Spencer Glantz, Jonathan M. Rothberg
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Publication number: 20220010386Abstract: Aspects of the disclosure relate to compositions and methods for amplifying and/or detecting one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens) in a biological sample obtained from a subject. In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. In some embodiments, the methods comprise isothermal amplification of a target nucleic acid and subsequent detection of the amplification products.Type: ApplicationFiled: July 9, 2021Publication date: January 13, 2022Applicant: Detect, Inc.Inventors: Henry Kemble, Spencer Glantz, Jeffrey Sabina, Sebastian Jaramillo-Riveri
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Publication number: 20210378643Abstract: Provided herein, in some embodiments, are breakable swabs for sample collection. In some embodiments, the swabs may be used in rapid diagnostic tests to detect one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens). In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. The swab may include a stem portion for handling and a head portion for collecting and/or holding a sample. After sample collection, the head portion may be inserted into a reaction tube or any other sample-receiving device. The stem portion of the swab may then be separated or detached from the head portion along a breakable portion.Type: ApplicationFiled: June 3, 2021Publication date: December 9, 2021Applicant: Detect, Inc.Inventors: Todd Roswech, Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth
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Publication number: 20210292825Abstract: Provided herein are rapid diagnostic tests, systems, and methods for detecting one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens, such as SARS-CoV-2 or an influenza virus) using isothermal nucleic acid amplification. The tests, systems, and methods described herein may be performed in a point-of-care setting or a home setting without specialized equipment.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth, Matthew Dyer, Todd Roswech, Eric Kauderer-Abrams, Jose Camara
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Publication number: 20210291181Abstract: Provided herein, in some embodiments, are rapid diagnostic tests to detect one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens) having a seal component. In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. Further embodiments provide methods of detecting genetic abnormalities. Diagnostic tests comprising a sample-collecting component, one or more reagents (e.g., lysis reagents, nucleic acid amplification reagents), a seal component, and a detection component (e.g., a component comprising a lateral flow assay strip and/or a colorimetric assay) are provided.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth
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Publication number: 20210293815Abstract: Provided herein, in some embodiments, are rapid diagnostic tests comprising a lateral flow strip and an integrated swab head. The tests may be used to detect, for example, one or more pathogens, such as viral, bacterial, fungal, parasitic, or protozoan pathogens. Further embodiments provide methods of detecting genetic abnormalities. Nucleic acid tests using the diagnostic tests are provided.Type: ApplicationFiled: October 9, 2020Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth, Owen Kaye-Kauderer
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Publication number: 20210292855Abstract: Described herein in one embodiment is software, which may be downloaded to a device, to guide a user through administration of a test. Test results may be uploaded, manually or automatically, to a device or communicated remotely through a network. In an embodiment, the test is a rapid test. In an embodiment, the rapid test detects presence of COVID-19. In an embodiment, the rapid test detects COVID-19 or influenza. In an embodiment, the rapid test detects influenza A or influenza B. In an embodiment, the rapid test detects a target nucleic acid. In an embodiment, the target nucleic acid represents one of a viral, bacterial, fungal, parasitic or protozoan pathogen. Each of the rapid tests may be self administrable.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth
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Publication number: 20210291165Abstract: Provided herein, in some embodiments, are rapid diagnostic tests to detect one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens). In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. Further embodiments provide methods of detecting genetic abnormalities. Diagnostic tests comprising a sample-collecting component, one or more reagents (e.g., lysis reagents, nucleic acid amplification reagents), and a detection component (e.g., a component comprising a lateral flow assay strip and/or a colorimetric assay) are provided.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth, Todd Roswech, Matthew Dyer, Jose Camara, Eric Kauderer-Abrams, Jonathan C. Schultz
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Publication number: 20210291177Abstract: A reagent carrier includes: a cap configured to fit on an opening of a reaction vessel; and a reagent confined by the cap. The cap may be configured to release the reagent when a user manipulates the cap while the cap is fitted on the opening of the reaction vessel. For example, the reagent may be released when the user twists the cap from a first position to a second position or when the user pushes on a surface of the cap. The cap may be configured to seal the opening of the reaction vessel when the cap is fitted on the opening of the reaction vessel. In some implementations, the cap may be a blister cap containing the reagent. In some implementations, the cap may include a cage containing the reagent. In some implementations, the cap may include a deformable structure containing the reagent.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth, Todd Roswech, Eric Kauderer-Abrams, Matthew Dyer, Jose Camara, Owen Kaye-Kauderer, John H. Leamon
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Publication number: 20210202041Abstract: The present disclosure provides, in some aspects, protein homolog discovery methods for enhanced co-evolution-based protein structure prediction.Type: ApplicationFiled: December 10, 2020Publication date: July 1, 2021Applicant: Homodeus, Inc.Inventors: Harry Kemble, Spencer Glantz, Jonathan M. Rothberg
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Publication number: 20210174909Abstract: The present disclosure provides, in some embodiments, techniques for using generative machine learning models to generate new functional protein sequences based on an input protein structure, such that the new functional protein sequences are structurally similar to the input protein structure but have new and diverse protein sequences. The techniques described herein may be used alone, or in conjunction with structural prediction algorithms and/or to generate diversified gene libraries in directed evolution techniques.Type: ApplicationFiled: December 10, 2020Publication date: June 10, 2021Applicant: Homodeus, Inc.Inventors: Jonathan M. Rothberg, Zhizhuo Zhang, Spencer Glantz
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Publication number: 20210174902Abstract: The present disclosure provides methods, compositions, kits, and systems for identifying recombinases and cognate site-specific recombinase recognition sites as well as method for using the identified recombinase/recognition site pairs.Type: ApplicationFiled: December 10, 2020Publication date: June 10, 2021Applicant: Homodeus, Inc.Inventors: Harry Kemble, Spencer Glantz, Jonathan M. Rothberg