Abstract: The present disclosure is generally directed to Siglec-9 ECDs and Siglec-9 ECD fusion molecules, and methods of treatment using Siglec-9 ECDs and Siglec-9 ECD fusion molecules.

Abstract: An alarm system can include one or more processors. Such processors can receive physiological parameter data associated with a patient. The one or more processors can also select an alarm pattern based at least in part on an indicator of an attribute of the patient. The alarm pattern can include a plurality of different thresholds and corresponding periods of time. Further, the one or more processors can generate an alarm when a value associated with the physiological parameter data satisfies at least one threshold of the plurality of thresholds for the period of time corresponding to the at least one threshold.

Abstract: A blood pressure device including a compressible material can be placed around a limb of a patient (e.g. a band or cuff). Further, the blood pressure device can include a sleeve that, at least partially, covers the compressible material and is capable of compressing the compressible material to occlude a patient's blood vessel without inflating the sleeve. In some embodiments, the sleeve can compress the compressible material using a motor assembly. This motor assembly can include a motor and any additional mechanical devices that can be used to facilitate compressing the compressible material. For example, the motor assembly may include one or more of the following: a cable, a pulley, and a gear assembly, such as a worm drive or any other gear assembly that can facilitate compressing the compressible material.

Abstract: An alarm system can include one or more processors. Such processors can receive physiological parameter data associated with a patient. The one or more processors can also select an alarm pattern based at least in part on an indicator of an attribute of the patient. The alarm pattern can include a plurality of different thresholds and corresponding periods of time. Further, the one or more processors can generate an alarm when a value associated with the physiological parameter data satisfies at least one threshold of the plurality of thresholds for the period of time corresponding to the at least one threshold.

Abstract: A casual shoe such as a sandal has a sole joined to an upper portion having a fixed dimension and adjustable openable and closable fastening straps with the straps extending from a fixed dimension upper portion to openings in a tab affixed to the upper portion and back again upon themselves. The folded fastening straps provide a securing pocket for the placement of a waterproof flat compartment. Another embodiment has an upper portion made up of two side members extending upwardly from each side of the sole, joined together and then extending downwardly and forwardly to join the sole as a single member.

Abstract: A method of amplification of one or more DNA sequences in a DNA containing sample, and methods of investigating such samples are provided in which an improved amplification cycling regime is used. The regime features a first phase and a second phase, the first phase including a denaturation temperature step, followed by an annealing temperature step, followed by a corrected annealed primer extension temperature step, these steps being followed by an annealing temperature step, corrected annealed primer extension temperature step prior to any further denaturation temperature steps being applied. Increased amplification from a given number of amplification cycles and maximised sensitivity for the DNA amplification process is achieved as a result.

Abstract: The invention provides a method for obtaining additional information about DNA mixtures arising from a variety of sources and/or a variety of concentrations.

Abstract: A method of amplification of one or more DNA sequences in a DNA containing sample, and methods of investigating such samples are provided in which an improved amplification cycling regime is used. The regime features a first phase and a second phase, the first phase including a denaturation temperature step, followed by an annealing temperature step, followed by a corrected annealed primer extension temperature step, these steps being followed by an annealing temperature step, corrected annealed primer extension temperature step prior to any further denaturation temperature steps being applied. Increased amplification from a given number of amplification cycles and maximised sensitivity for the DNA amplification process is achieved as a result.

Abstract: A method of evaluating primers for use in the amplification of DNA sequences, a method of producing a mixture of primers for such a purpose and a method of amplifying a plurality of DNA sequences using a mixture of primers is provided in which the evaluation involves performing one or more initial evaluations, obtaining a plurality of SNP sites and related potential primer identities which are passes, generating primers corresponding to those primer identities and conducting a test amplification process using those primers in conjunction with a further evaluation of the results, the pass primers therefrom forming a pool of primer candidates from which one or more primers for use in the amplification of DNA sequences are selected.