Abstract: An apparatus for perforating a subterranean formation comprises a first perforating gun (33b) having a box end (112) having a nose, a second perforating gun (33a) having a pin end (118) having a shoulder (124); and an alignment assembly. The alignment assembly includes internal threads formed on the box end, external threads formed on the pin end, and an alignment member (120) positioned between the box end nose and the pin end shoulder. The internal threads and the external threads are specified to form an angular alignment between the first perforating gun and the second perforating gun within a first specified angular tolerance. The alignment member has at least one characteristic selected to vary the angular alignment within the first specified angular tolerance without degrading a locking force connecting the first perforating gun to the second perforating gun.

Abstract: Compounds of general formula (1): wherein R1, R2, R3, R4, R5a, R* X1, X2, Z and Y are as defined herein are positive modulators of the N H calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

Abstract: The invention relates to new substituted heteroaryls of formula 1 wherein A is selected from the group consisting of N and CH D is selected from the group consisting of CH, N, NH, E is C, T is selected from the group consisting of C and N, G is selected from the group consisting of C and N, and wherein each of the broken (dotted) double bonds in ring 1 are selected from either a single bond or a double bond under the proviso that all single and double bonds of ring 1 are arranged in such a way that they all form together with ring 2 an aromatic ring system, and wherein R1, M and R3 are defined according to claim 1, and to the above compounds for the treatment of a disease selected from the group consisting of asthma, COPD, allergic rhinitis, allergic dermatitis, lupus erythematodes, lupus nephritis and rheumatoid arthritis.