Abstract: Co-crystals comprising the Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LBD) and a cyclopentenone prostaglandin are provided. Also provided are methods of identifying or designing Nurr1-modulating ligands and compounds based on the crystal structures described herein as well as the applications of said ligands and compounds as Nurr1 modulators or medicaments.

Abstract: Co-crystals comprising the Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LBD) and a cyclopentenone prostaglandin are provided. Also provided are methods of identifying or designing Nurr1-modulating ligands and compounds based on the crystal structures described herein as well as the applications of said ligands and compounds as Nurr1 modulators or medicaments.

Abstract: Co-crystals comprising the Nuclear receptor related 1 protein-ligand binding domain (Nurr1-LBD) and a cyclopentenone prostaglandin are provided. Also provided are methods of identifying or designing Nurr1-modulating ligands and compounds based on the crystal structures described herein as well as the applications of said ligands and compounds as Nurr1 modulators or medicaments.

Abstract: A method of transmitting selected regions of interest of digital video data at selected resolutions, including: capturing digital video; compressing the digital video into a sequence of individual high resolution JPEG 2000 frames and simultaneously extracting from the compressed high resolution JPEG 2000 frames a lower resolution; storing the individual high resolution JPEG 2000 frames in a storage device; creating a video sequence of the lower resolution representation; transmitting the video sequence of the lower resolution representation to a user; creating one or more video sequences of selected regions of interest at selected resolutions greater than the resolution of the video sequence of the lower resolution representation; transmitting one or more video sequences of selected regions of interest at selected resolutions; and repeating the prior two steps at incrementally increased resolutions until a desired resolution of the selected region of interest is reached according to a viewing objective.