Patents by Inventor Sreekanth SURAVAJJALA

Sreekanth SURAVAJJALA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR REDUCING LOW MOLECULAR WEIGHT SPECIES OF RECOMBINANTLY-PRODUCED PROTEINS
    Publication number: 20240209115
    Abstract: The present invention relates to methods for reducing low molecular weight species of recombinantly-produced proteins. In particular, methods of reducing the formation of low molecular weight species produced by a host cell during the cell culture process through pH control of the production cell culture are disclosed. Also disclosed are methods for reducing or eliminating the generation of alternative splice variants by a host cell during production of a recombinant protein.
    Type: Application
    Filed: April 28, 2022
    Publication date: June 27, 2024
    Applicants: AMGEN INC., AMGEN RESEARCH (MUNICH) GmbH
    Inventors: Anika MENTHE, Joseph BASCONI, Nitya M. JACOB, Russell JAMPOL, Huong Thi Ngoc LE, Kim LE, Jessica PEDROSO, Jennitte STEVENS, Sreekanth SURAVAJJALA, Charilyn TEJAMO, Pheng YAM
  • RELATIVE UNPAIRED GLYCANS IN ANTIBODY PRODUCTION METHODS
    Publication number: 20240043501
    Abstract: Provided herein are methods of producing an antibody composition comprising determining the relative unpaired afucosylated glycan content and/or the relative unpaired high mannose glycan content of a sample of the antibody composition and selecting the antibody composition for downstream processing based on the relative unpaired afucosylated glycan content and/or relative unpaired high mannose glycan content and/or the ADCC level of the antibody composition. Related methods of determining the relative unpaired glycan content of an antibody composition and methods of modifying the ADCC level of an antibody composition are provided herein.
    Type: Application
    Filed: October 14, 2021
    Publication date: February 8, 2024
    Applicant: AMGEN INC.
    Inventors: Alla POLOZOVA, Chendi NIU, Ramsey A. SALEEM, Sreekanth SURAVAJJALA
  • MATERIALS AND METHODS FOR PROTEIN PROCESSING
    Publication number: 20240010672
    Abstract: Described herein are materials and methods for protein production and analysis.
    Type: Application
    Filed: November 1, 2021
    Publication date: January 11, 2024
    Inventors: Sreekanth SURAVAJJALA, Jennifer Lynn LIPPENS