Patents by Inventor Sreenivasulu Megati

Sreenivasulu Megati has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 9724343
    Abstract: The present invention provides a compound of formua I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: August 8, 2017
    Assignee: Wyeth, LLC
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20170007597
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Application
    Filed: September 26, 2016
    Publication date: January 12, 2017
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 9492445
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: November 15, 2016
    Assignee: Wyeth, LLC
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20160113923
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Application
    Filed: September 30, 2015
    Publication date: April 28, 2016
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 9180125
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: November 10, 2015
    Assignee: Wyeth, LLC
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20150150866
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Application
    Filed: July 2, 2014
    Publication date: June 4, 2015
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 8822490
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: September 2, 2014
    Assignee: Wyeth LLC
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 8455644
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: June 4, 2013
    Assignee: Wyeth
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 8420663
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: April 16, 2013
    Assignee: Wyeth
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles K. Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20130011929
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Application
    Filed: July 11, 2012
    Publication date: January 10, 2013
    Applicant: Wyeth
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Peripheral Opioid Receptor Antagonists and Uses Thereof
    Publication number: 20120316191
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Application
    Filed: August 9, 2012
    Publication date: December 13, 2012
    Applicant: Wyeth
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 8247425
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: August 21, 2012
    Assignee: Wyeth
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Process for preparing quinoline compounds and products obtained therefrom
    Patent number: 7781427
    Abstract: Methods for synthesizing tetrahydroquinoline-containing compounds are provided, along with synthetic intermediates and products associated with such methods.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: August 24, 2010
    Assignee: Wyeth LLC
    Inventors: Christoph Dehnhardt, Sreenivasulu Megati, Jerry Sun
  • PROCESS FOR PREPARING QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED THEREFROM
    Publication number: 20100196714
    Abstract: Methods for synthesizing tetrahydroquinoline-containing compounds are provided, along with synthetic intermediates and products associated with such methods.
    Type: Application
    Filed: April 7, 2010
    Publication date: August 5, 2010
    Applicant: Wyeth
    Inventors: Christoph Dehnhardt, Sreenivasulu Megati, Jerry Sun
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20100120813
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Application
    Filed: September 30, 2009
    Publication date: May 13, 2010
    Applicant: Wyeth
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Diazepinoquinolines, synthesis thereof, and intermediates thereto
    Patent number: 7671196
    Abstract: The present invention relates to methods for synthesizing compounds useful as 5HT2C agonists or partial agonists, derivatives thereof, and to intermediates thereto.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: March 2, 2010
    Assignee: Wyeth LLC
    Inventors: Sreenivasulu Megati, Anita Wai-Yin Chan, Gregg B. Feigelson
  • Preparation of 6-hydroxyequilenins
    Patent number: 7601857
    Abstract: This invention relates to a process for the preparation of 6-hydroxyequilenins, which are useful as estrogenic agents.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: October 13, 2009
    Assignee: Wyeth
    Inventors: Sreenivasulu Megati, Galina Vid, Arthur G. Mohan, Panolil Raveendranath, John Potoski
  • Process for the synthesis of cPLA inhibitors
    Patent number: 7582771
    Abstract: A process for making the compound of formula (I) wherein Ac represents acetate; X represents O or CH2; Y represents C1-C6alkyl; and Z is selected from the group consisting of H, halogen, CN, CHO, CF3, OCF3, OH, C1-C6alkyl, C1-C6alkoxy, C1-C6thioalkyl, NH2, N(C1-C6alkyl)2, NH(C1-C6alkyl), NC(O)—(C1C6alkyl), and NO2. In his process, a compound of formula (II) is reacted with hydrazine to form a primary alkylamine, and then the primary alkylamine is reacted with acetic anhydride, to produce the compound of formula (I).
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: September 1, 2009
    Assignee: Wyeth
    Inventors: Christoph M. Dehnhardt, Sreenivasulu Megati, Ronald S. Michalak, Panolil Raveendranath, Jianxin Ren, Charles C. Wu, Yangzhong Wu
  • CHIRAL SYNTHESIS OF DIAZEPINOQUINOLINES
    Publication number: 20090093630
    Abstract: The present invention relates to improved methods of resolution and recrystallization for synthesizing compounds useful as 5HT2C agonists or partial agonists, including intermediates thereto.
    Type: Application
    Filed: September 19, 2008
    Publication date: April 9, 2009
    Applicant: Wyeth
    Inventors: Sreenivasulu Megati, Shilpa Bhansali, Christoph Dehnhardt, Subodh Deshmukh, Peter Fung, Michael MacEwan, Robert J. Tinder
  • CRYSTALLINE FORMS AND POLYMORPHS OF N-(3-(DIMETHYLAMINO)PROPYL)-4-(4-(3-FLUORO-4-METHOXYPHENYL) PYRIMIDIN-2-YLAMINO) BENZENESULFONAMIDE AS PHARMACEUTICALLY ACCEPTABLE SALTS
    Publication number: 20080275073
    Abstract: The present invention relates to one or more crystalline forms and polymorphs of compounds of formula I: in the form of pharmaceutically acceptable salts. The present invention is directed to crystalline polymorphs and forms of specific anilino-pyrimidine benzenesulfonamide compounds of formula I as pharmaceutically acceptable salts.
    Type: Application
    Filed: April 18, 2008
    Publication date: November 6, 2008
    Applicant: Wyeth
    Inventors: Mahmoud Mirmehrabi, Sreenivasulu Megati, Abdolsamad Tadayon, Subodh Deshmukh