Abstract: An assembly for an aircraft propulsion system includes a case assembly, at least one seal, a first pressure sensor, and a computing system. The case assembly forms a cavity. The at least one seal is disposed on the case assembly. The at least one seal is configured to seal the cavity. The first pressure sensor is in fluid communication with the cavity. The first pressure sensor is configured to measure a first pressure within the cavity. The computing system is in signal communication with the first pressure sensor. The computing system includes a processor in communication with a non-transitory memory storing instructions, which instructions when executed by the processor, cause the processor to compare the first pressure to a pressure threshold value to identify a wear condition of the at least one seal.

Abstract: A system for providing code suggestions according to licensing criteria is described. The system comprises computing devices that implement a code suggestion service. The code suggestion service receives a request that specifies licensing criteria via an interface of the code suggestion service. The code suggestion service determines respective licenses for respective source code files according to a source code attribution database from parsing the plurality of source code files that are applicable to the plurality of source code files. The code suggestion service generates a set of candidate code suggestions based, at least in part, on the plurality of source code files. The code suggestion service determines code suggestions from the set of candidate code suggestions that satisfy the licensing criteria based on the respective licenses. The code suggestion service provides the code suggestions determined from the set of candidate source code files that satisfy the licensing criteria.

Abstract: Disclosed are methods of obtaining a cell population enriched for T cells with a phenotype, the method comprising: (a) obtaining a bulk population of T cells from a tumor sample of a patient; (b) specifically selecting T cells with a phenotype comprising markers CD3+, CD39?, and CD69? from the bulk population; and (c) separating the cells selected in (b) from cells which lack the phenotype to obtain a cell population enriched for T cells with the phenotype. Related methods of treating or preventing cancer, methods of selecting a therapy for a cancer patient, and methods for predicting the clinical response to immunotherapy in a cancer patient are also disclosed. Isolated or purified cell population obtained according to the methods and related pharmaceutical compositions are also disclosed.

Abstract: A system for troubleshooting network problems is disclosed. A model can use demographic information, network usage information, and network membership information to determine an importance of a problem. The importance of the problem for the user who reported the problem, a number of other users affected by the problem, and the importance of the problem to the other users can be used to determine a priority for resolving the problem. Before and after a work order is executed to resolve the problem, network metrics can be gathered, including aggregate network metrics, and automatically presented in various user interfaces. The analysis of the metrics can be used to update a database of which work orders are assigned in response to which problems.

Abstract: Computer-implemented systems and methods are disclosed to interface with one or more storage devices storing a plurality of documents, wherein each of the plurality of documents is associated with one or more tags of one or more predefined hierarchies of tags, wherein the one or more hierarchies of tags include multiple dimensions. In accordance with some embodiments, a method is provided to identify one or more documents from the data storage devices. The method comprises acquiring, via an interface, a selection of one or more tags of the one or more predefined hierarchies of tags. The method further comprises identifying one or more documents from the data storage devices in response to the selection, the identified one or more documents having tags that have a relationship with the selected tags, and providing data corresponding to the identified documents for displaying in the interface.

Abstract: Provided are methods of preparing an enriched population of T cells having antigenic specificity for a target antigen. The method may comprise isolating T cells from a blood sample of a patient; selecting the isolated T cells which have a gene expression profile; and separating the selected T cells from the unselected cells. The separated selected T cells provide an enriched population of T cells having antigenic specificity for the target antigen. Methods of isolating a TCR, preparing a population of cells that express a TCR, isolated TCRs, isolated populations of cells, pharmaceutical compositions, and methods of treating or preventing a condition in a mammal are also provided.

Abstract: A method of directly measuring moisture content in an oil-filled transformer includes using an optical fiber that having a grating sensor, such as a Fiber Bragg grating, defined in the optical fiber. The various conductors (windings) in the transformer are insulated using an insulator such as paper and insulating oil is filled inside the transformer. Moisture in the transformer is absorbed by the paper that surrounds the windings. A moisture content at a specific location can be measured by placing the optical fiber with the grating sensor directly at the specific location to be measured. A physical parameter of the paper that absorbed moisture changes over time, causing a change in the grating sensor of the optical fiber which changes the spectral response of optical signals that are reflected by the grating sensor. The method provides an accurate method of measuring the moisture inside the transformer at the specific location.

Abstract: Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.

Abstract: Provided are methods of preparing an enriched population of T cells having antigenic specificity for a target antigen. The method may comprise isolating T cells from a tumor sample of a patient; selecting the isolated T cells which have a gene expression profile; and separating the selected T cells from the unselected cells. The separated selected T cells provide an enriched population of T cells having antigenic specificity for the target antigen. Methods of isolating a T cell receptor (TCR), preparing a population of cells that express a TCR, isolated TCRs, isolated populations of cells, pharmaceutical compositions, and methods of treating or preventing a condition in a mammal are also provided.

Abstract: An airfoil including a plurality of composite plies extending from a leading edge to a trailing edge and between a tip and a root. The airfoil further includes a frangible airfoil portion at the tip extending between the leading edge and the trailing edge and extending between the tip and a frangible line along a span including a first plurality of composite plies. The frangible airfoil portion includes a first plurality of composite plies including fibers having a first fiber modulus. The airfoil further includes a residual airfoil portion extending from the frangible line to the root along the span including a second plurality of composite plies. The second plurality of composite plies including one or more plies having a second fiber modulus. The second fiber modulus is greater than the first fiber modulus. Further, the residual airfoil portion meets the frangible airfoil portion at the frangible line.

Abstract: Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.

Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.

Abstract: Techniques allow a computer to responsively search for graph shapes similar to a user-selected graph shape much faster. Data can be pre-processed and stored as vectors, along with an index. The index can be used to find similar vectors that represent graph shapes similar to a user-selected shape in a computationally efficient manner. Vectors of multiple resolutions can be used to anticipate different sizes of a graph that a user can select, and comparisons can be repeated and refined. When a satisfactorily small number of candidate vectors are determined, more computationally intensive distance calculations can be performed on data reconstructed from the vectors.

Abstract: Disclosed are various approaches for integrating chat conversations with email messages. A user can request to view a received email message exchanged between multiple entities. If there is an established chat conversation associated with the user that is linked to the email message, the user interface including the email message can include a messaging component that can allow a user to view the corresponding chat conversation. The user interface can also include a component that allows the user to initiate a chat conversation with another party included in the email without switching to a third-party service.

Abstract: A system for troubleshooting network problems is disclosed. A model can use demographic information, network usage information, and network membership information to determine an importance of a problem. The importance of the problem for the user who reported the problem, a number of other users affected by the problem, and the importance of the problem to the other users can be used to determine a priority for resolving the problem. Before and after a work order is executed to resolve the problem, network metrics can be gathered, including aggregate network metrics, and automatically presented in various user interfaces. The analysis of the metrics can be used to update a database of which work orders are assigned in response to which problems.

Abstract: The invention relates to a method for continuously producing and secreting recombinant Glucagon-like peptide-1 (GLP-1) by bacteria, more specifically E. coli. More specifically, the invention relates to use of novel bacterial expression vector for producing and enabling extracellular secretion of GLP-1, use of novel media composition for enhancing the secretion and enabling purification, and a perfusion-based fermentation system for continuous production and separation of recombinant GLP-1 peptide.

Abstract: Techniques allow a computer to responsively search for graph shapes similar to a user-selected graph shape much faster. Data can be pre-processed and stored as vectors, along with an index. The index can be used to find similar vectors that represent graph shapes similar to a user-selected shape in a computationally efficient manner. Vectors of multiple resolutions can be used to anticipate different sizes of a graph that a user can select, and comparisons can be repeated and refined. When a satisfactorily small number of candidate vectors are determined, more computationally intensive distance calculations can be performed on data reconstructed from the vectors.

Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.

Abstract: A system for troubleshooting network problems is disclosed. A model can use demographic information, network usage information, and network membership information to determine an importance of a problem. The importance of the problem for the user who reported the problem, a number of other users affected by the problem, and the importance of the problem to the other users can be used to determine a priority for resolving the problem. Before and after a work order is executed to resolve the problem, network metrics can be gathered, including aggregate network metrics, and automatically presented in various user interfaces. The analysis of the metrics can be used to update a database of which work orders are assigned in response to which problems.

Abstract: Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+HNSCC-specific checkpoints for targeted immunotherapy.