Abstract: A system for utilizing human machine interfaces to engage at least one passenger when a driver of a vehicle is distracted includes a system controller in communication with a plurality of passenger human machine interfaces and adapted to modify a display screen of a front seat passenger HMI, and an occupant monitoring system adapted to monitor the driver of the vehicle and the at least one passenger within the vehicle, the system controller adapted to determine, with a distracted driver algorithm within the system controller and data from the occupant monitoring system that the driver of the vehicle is distracted, and, when the driver of the vehicle is distracted, to actuate the plurality of passenger HMIs to engage the at least one passenger and encourage the at least one passenger to engage with the driver of the vehicle.

Abstract: A system for initiating an automated slowdown procedure within a vehicle includes a system controller adapted to detect a request for initiation of an automated slowdown procedure, a human machine interface (HMI), wherein the system controller is adapted to prompt, via the HMI, the driver of the vehicle for verification to initiate the automated slowdown procedure, and a vehicle control module, wherein the system controller is adapted to initiate, via the vehicle control module, the automated slowdown procedure when either one of the driver provides, via the HMI, verification to initiate the automated slowdown procedure, or a response from the driver is not received within a pre-determined time.

Abstract: A system for detecting an impairment of an operator of a vehicle includes an alcohol sensor, a camera, a start control, and a controller in electrical communication with the alcohol sensor, the camera, and the start control, the controller including a processor and a memory, the memory including instructions such that the processor is programmed to: determine that alcohol is detected using the alcohol sensor, disable the start control based on the detection of alcohol, perform a gaze nystagmus assessment of the operator using the camera, determine if the operator is impaired based on the gaze nystagmus assessment, and enable the start control when the operator is not impaired.

Abstract: A system for utilizing human machine interfaces to engage at least one passenger when a driver of a vehicle is distracted includes a system controller in communication with a plurality of passenger human machine interfaces and adapted to modify a display screen of a front seat passenger HMI, and an occupant monitoring system adapted to monitor the driver of the vehicle and the at least one passenger within the vehicle, the system controller adapted to determine, with a distracted driver algorithm within the system controller and data from the occupant monitoring system that the driver of the vehicle is distracted, and, when the driver of the vehicle is distracted, to actuate the plurality of passenger HMIs to engage the at least one passenger and encourage the at least one passenger to engage with the driver of the vehicle.

Abstract: Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.

Abstract: A computer-implemented method comprising performing a training process, the training process comprising: using first and second image encoder networks, generating first and second sets of embeddings based on a pair of first and second input images, respectively; generating first and second nearest neighbor graphs, NNGs, based on the first and second sets of embeddings, respectively; using at least one graph neural network, GNN, extracting first and second representations from the first and second NNGs, respectively; and adjusting at least one network weight of the first image encoder network based on a difference between the first and second representations.

Abstract: Disclosed are methods of treating or preventing cancer in a mammal, the method comprising: (a) isolating T cells from a tumor sample from the mammal, wherein the isolated T cells are one or both of exhausted and differentiated, and the isolated T cells have antigenic specificity for a tumor-specific antigen expressed by the tumor sample from the mammal, wherein the tumor-specific antigen is a tumor-specific neoantigen or an antigen with a tumor-specific driver mutation; and optionally expanding the numbers of isolated, tumor antigen-specific T cells; and (b) administering to the mammal (i) the isolated T cells of (a) and (ii) a vaccine which specifically stimulates an immune response against the tumor-specific antigen for which the isolated T cells have antigenic specificity.

Abstract: The invention relates to a method for continuously producing and secreting recombinant Glucagon-like peptide-1 (GLP-1) by bacteria, more specifically E. coli. More specifically, the invention relates to use of novel bacterial expression vector for producing and enabling extracellular secretion of GLP-1, use of novel media composition for enhancing the secretion and enabling purification, and a perfusion-based fermentation system for continuous production and separation of recombinant GLP-1 peptide.

Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.

Abstract: Techniques allow a computer to responsively search for graph shapes similar to a user-selected graph shape much faster. Data can be pre-processed and stored as vectors, along with an index. The index can be used to find similar vectors that represent graph shapes similar to a user-selected shape in a computationally efficient manner. Vectors of multiple resolutions can be used to anticipate different sizes of a graph that a user can select, and comparisons can be repeated and refined. When a satisfactorily small number of candidate vectors are determined, more computationally intensive distance calculations can be performed on data reconstructed from the vectors.

Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.

Abstract: A predictive model for classification of tissue rupture risk is generated by providing a computer aided design (CAD) model suitable for simulating a balloon expandable transcatheter heart valve, and computing stress, strain, and/or displacement at the tissue as a function of expansion of the expandable transcatheter heart valve. The computed stress, strain, and/or displacement at the tissue enables determination of low, moderate or high tissue rupture risk as a function of the expansion at time of the expandable transcatheter heart valve deployment into a patient.

Abstract: A model of an in vivo heart valve device implanted in a patient is generated by providing a known model of a pre-implantation heart valve device, performing an imaging scan on the patient having an implanted heart valve device to obtain at least one patient specific landmark, deforming the known model to fit the at least one patient specific landmark to obtain a constructed patient-specific valve model, and simulating a valve leaflet and skirt for the constructed patient-specific valve model by finite element analysis. The constructed patient-specific valve model accurately represents geometries of the implanted heart valve device in its current in vivo form with an error less than 0.5 mm.

Abstract: A heart valve model includes a parametric leaflet model representing geometries of a heart valve constructed based on at least one landmark point associated with the heart valve. The heart valve model includes a ray casted anatomical structure constructed based on an automatic aortic root reconstruction algorithm to extract a shape of an aorta. The heart valve also includes an additional anatomical structure, wherein the parametric leaflet model, the ray casted anatomical structure, and the additional anatomical structure are combined to obtain the heart valve model.

Abstract: An assembly for an aircraft propulsion system includes a case assembly, at least one seal, a first pressure sensor, and a computing system. The case assembly forms a cavity. The at least one seal is disposed on the case assembly. The at least one seal is configured to seal the cavity. The first pressure sensor is in fluid communication with the cavity. The first pressure sensor is configured to measure a first pressure within the cavity. The computing system is in signal communication with the first pressure sensor. The computing system includes a processor in communication with a non-transitory memory storing instructions, which instructions when executed by the processor, cause the processor to compare the first pressure to a pressure threshold value to identify a wear condition of the at least one seal.

Abstract: Disclosed are methods of obtaining a cell population enriched for T cells with a phenotype, the method comprising: (a) obtaining a bulk population of T cells from a tumor sample of a patient; (b) specifically selecting T cells with a phenotype comprising markers CD3+, CD39?, and CD69? from the bulk population; and (c) separating the cells selected in (b) from cells which lack the phenotype to obtain a cell population enriched for T cells with the phenotype. Related methods of treating or preventing cancer, methods of selecting a therapy for a cancer patient, and methods for predicting the clinical response to immunotherapy in a cancer patient are also disclosed. Isolated or purified cell population obtained according to the methods and related pharmaceutical compositions are also disclosed.

Abstract: A system for troubleshooting network problems is disclosed. A model can use demographic information, network usage information, and network membership information to determine an importance of a problem. The importance of the problem for the user who reported the problem, a number of other users affected by the problem, and the importance of the problem to the other users can be used to determine a priority for resolving the problem. Before and after a work order is executed to resolve the problem, network metrics can be gathered, including aggregate network metrics, and automatically presented in various user interfaces. The analysis of the metrics can be used to update a database of which work orders are assigned in response to which problems.

Abstract: Computer-implemented systems and methods are disclosed to interface with one or more storage devices storing a plurality of documents, wherein each of the plurality of documents is associated with one or more tags of one or more predefined hierarchies of tags, wherein the one or more hierarchies of tags include multiple dimensions. In accordance with some embodiments, a method is provided to identify one or more documents from the data storage devices. The method comprises acquiring, via an interface, a selection of one or more tags of the one or more predefined hierarchies of tags. The method further comprises identifying one or more documents from the data storage devices in response to the selection, the identified one or more documents having tags that have a relationship with the selected tags, and providing data corresponding to the identified documents for displaying in the interface.

Abstract: Provided are methods of preparing an enriched population of T cells having antigenic specificity for a target antigen. The method may comprise isolating T cells from a blood sample of a patient; selecting the isolated T cells which have a gene expression profile; and separating the selected T cells from the unselected cells. The separated selected T cells provide an enriched population of T cells having antigenic specificity for the target antigen. Methods of isolating a TCR, preparing a population of cells that express a TCR, isolated TCRs, isolated populations of cells, pharmaceutical compositions, and methods of treating or preventing a condition in a mammal are also provided.

Abstract: A method of directly measuring moisture content in an oil-filled transformer includes using an optical fiber that having a grating sensor, such as a Fiber Bragg grating, defined in the optical fiber. The various conductors (windings) in the transformer are insulated using an insulator such as paper and insulating oil is filled inside the transformer. Moisture in the transformer is absorbed by the paper that surrounds the windings. A moisture content at a specific location can be measured by placing the optical fiber with the grating sensor directly at the specific location to be measured. A physical parameter of the paper that absorbed moisture changes over time, causing a change in the grating sensor of the optical fiber which changes the spectral response of optical signals that are reflected by the grating sensor. The method provides an accurate method of measuring the moisture inside the transformer at the specific location.