Patents by Inventor Sridhar Rabindran

Sridhar Rabindran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272
    Publication number: 20070104721
    Abstract: A combination of temsirolimus and herceptin in the treatment of cancer is provided. A combination of temsirolimus and HKI-272 is provided. A combination of herceptin and HKI-272 is also provided. Regimens and kits for treatment of metastatic breast cancer, containing herceptin, temsirolimus and/or HKI-272, optionally in combination with other anti-neoplastic agents, or immune modulators are described.
    Type: Application
    Filed: November 2, 2006
    Publication date: May 10, 2007
    Applicant: Wyeth
    Inventors: Laurence Moore, Charles Zacharchuk, Sridhar Rabindran
  • Methods of synthesizing 6-alkylaminoquinoline derivatives
    Publication number: 20060270670
    Abstract: The present invention is directed to a method of synthizing compounds of formula (I): wherein X, Z, V, R1, R3, R4, G2, n, x, y, and z are defined herein. This invention also includes a method of preparing acid compounds of formula (VII): wherein R is H, and R4, x, y, and z are as defined herein and PG is a protecting group. This invention is also directed to (E)N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(methylamino)-2-butenamide, compositions containing it and methods of using the to treat cancer.
    Type: Application
    Filed: May 25, 2006
    Publication date: November 30, 2006
    Inventors: Warren Chew, Youchu Wang, Sridhar Rabindran, Carolyn Discafani-Marro, John McGinnis II, Allan Wissner
  • Protein tyrosine kinase enzyme inhibitors
    Publication number: 20050059678
    Abstract: This invention provides compounds of formula 1, having the structure wherein R1, R2, R3, R4, and R5 are described within the specification.
    Type: Application
    Filed: September 10, 2004
    Publication date: March 17, 2005
    Applicant: Wyeth
    Inventors: Allan Wissner, Sridhar Rabindran, Hwei-Ru Tsou
  • Cell stress transcriptional factors
    Patent number: 5756343
    Abstract: The present invention relates to DNA sequence coding for part or all of the heat shock transcription factor or heat shock factor (HSF) proteins derived from humans and Drosophila, and the proteins encoded by these sequences.The present invention also includes methods for detecting HSF in a biological sample. The presence of HSF in the nucleus of a cell can be detected with specific anti-HSF antibody reagents. The presence of such HSF proteins in the nucleus indicates a stressed condition including diseases. Furthermore, the presence of multimeric HSF in the crude or fractionated cell extract is indicative of a stressed state.
    Type: Grant
    Filed: January 7, 1994
    Date of Patent: May 26, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Carl Wu, Joachim Clos, J. Timothy Westwood, Sridhar Rabindran