Abstract: Disclosed are methods of treating a subject having hepatocellular carcinoma (HCC) comprising administering an HCC therapeutic to a subject identified in need thereof, wherein the subject was identified as being in need of thereof by determining the subject had an increased expression level of glypican 3 (GPC3) and/or an increased number of GPC3-enriched exosomes/increase level of exosome-derived GPC3 (eGPC3) as compared to a control. Disclosed are methods of diagnosing and treating a subject comprising detecting whether GPC3 expression is increased in the subject and/or GPC3-enriched exosomes are increased; diagnosing the subject with HCC when the presence of elevated GPC3 and/or an increased number of GPC3-enriched exosomes is detected; and administering a therapeutically effective amount of an HCC therapeutic to the subject.

Abstract: A system for publishing content for broadcast includes one or more processors. The one or more processors are configured to identify, in response to a user query, one or more video clips of a plurality of video clips stored in one or more storage devices. The one or more processors are further configured to display an indication of the one or more identified video clips and generate, based on a user selection of the one or more identified video clips, a rundown comprising the user-selected video clips. The one or more processors are further configured to determine that each of the user-selected video clips comply with a plurality of broadcasting requirements stored in the one or more storage devices and generate a playlist comprising each of the user-selected video clips of the rundown that comply with the plurality of broadcasting requirements.

Abstract: A system for publishing content for broadcast includes one or more processors. The one or more processors are configured to identify, in response to a user query, one or more video clips of a plurality of video clips stored in one or more storage devices. The one or more processors are further configured to display an indication of the one or more identified video clips and generate, based on a user selection of the one or more identified video clips, a rundown comprising the user-selected video clips. The one or more processors are further configured to determine that each of the user-selected video clips comply with a plurality of broadcasting requirements stored in the one or more storage devices and generate a playlist comprising each of the user-selected video clips of the rundown that comply with the plurality of broadcasting requirements.

Abstract: Compositions are disclosed of combinations of small interfering RNAs (siRNA) that can inhibit the replication of hepatitis C virus (HCV) in liver cells, along with methods of co-administering the siRNAs to subjects. Further, methods are disclosed for improving the delivery of nucleic acids to the liver.

Abstract: The present invention provides an isolated peptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1 to SEQ ID NO:36, as well as derivatives thereof comprising various N-terminal and C-terminal chemical moieties, substituted analogs thereof, and fragments thereof. The peptides of the invention are useful for treating and preventing a Flavivirus invention. Pharmaceutical compositions comprising the peptides, and methods of treating or preventing Flavivirus infections, are also provided.

Abstract: The present invention provides an isolated peptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1 to SEQ ID NO:36, as well as derivatives thereof comprising various N-terminal and C-terminal chemical moieties, substituted analogs thereof, and fragments thereof. The peptides of the invention are useful for treating and preventing a Flavivirus invention. Pharmaceutical compositions comprising the peptides, and methods of treating or preventing Flavivirus infections, are also provided.

Abstract: The present invention relates to peptides and methods of inhibiting fusion between the virion envelope of Flaviviruses and membranes of the target cell, the process that delivers the viral genome into the cell cytoplasm. The invention provides for methods which employ peptides or peptide derivatives to inhibit Flavivirus:cell fusion. The present invention is based in part on the discovery that E1 envelope glycoprotein of hepaciviruses and E2 envelope glycoprotein of pestivirus have previously undescribed structures, truncated class II fusion proteins. The present invention provides peptides and methods of treatment and prophylaxis of diseases induced by Flaviviruses.

Abstract: A method for selecting investment assets for a portfolio is based upon a score derived for each asset which is indicative of its style, for example, whether a stock is predominantly a growth or a value stock. Different sets of score factors are designated for assessing an asset's score with respect to a first characteristic, or style, indicated by one set of score factors and with respect to a second characteristic, or style, indicated by the second set of factors. Based on the asset's score from one set of score factors relative to its score from a second set of score factors, the asset's predominant character can be determined. Also, an index for a number of assets can be computed in which each constituent asset's weight is determined by the asset's score with respect to one style or another.

Abstract: The present invention relates to peptides and methods of inhibiting fusion between the virion envelope of Flaviviruses and membranes of the target cell, the process that delivers the viral genome into the cell cytoplasm. The invention provides for methods which employ peptides or peptide derivatives to inhibit Flavivirus:cell fusion. The present invention is based in part on the discovery that E1 envelope glycoprotein of hepaciviruses and E2 envelope glycoprotein of pestivirus have previously undescribed structures, truncated class II fusion proteins. The present invention provides peptides and methods of treatment and prophylaxis of diseases induced by Flaviviruses.

Abstract: The present invention relates to peptides and methods of inhibiting fusion between the virion envelope of Flaviviruses and membranes of the target cell, the process that delivers the viral genome into the cell cytoplasm. The invention provides for methods which employ peptides or peptide derivatives to inhibit Flavivirus:cell fusion. The present invention is based in part on the discovery that E1 envelope glycoprotein of hepaciviruses and E2 envelope glycoprotein of pestivirus have previously undescribed structures, truncated class II fusion proteins. The present invention provides peptides and methods of treatment and prophylaxis of diseases induced by Flaviviruses.

Abstract: A method for selecting investment assets for a portfolio is based upon a score derived for each asset which is indicative of its style, for example, whether a stock is predominantly a growth or a value stock. Different sets of score factors are designated for assessing an asset's score with respect to a first characteristic, or style, indicated by one set of score factors and with respect to a second characteristic, or style, indicated by the second set of factors. Based on the asset's score from one set of score factors relative to its score from a second set of score factors, the asset's predominant character can be determined. Also, an index for a number of assets can be computed in which each constituent asset's weight is determined by the asset's score with respect to one style or another.

Abstract: The present invention relates to peptides and methods of inhibiting fusion between the virion envelope of Flaviviruses and membranes of the target cell, the process that delivers the viral genome into the cell cytoplasm. The invention provides for methods which employ peptides or peptide derivatives to inhibit Flavivirus:cell fusion. The present invention is based in part on the discovery that E1 envelope glycoprotein of hepaciviruses and E2 envelope glycoprotein of pestivirus have previously undescribed structures, truncated class II fusion proteins. The present invention provides peptides and methods of treatment and prophylaxis of diseases induced by Flaviviruses.