Abstract: The invention relates to G protein-coupled receptor (GPCR) microarrays on porous substrates for structural or functional analyses of GPCRs, and methods of preparing porous substrate surfaces for receiving membranes that comprise GPCRs. In one embodiment, a GPCR microarray of the invention comprises a membrane adhered to an upper surface of a porous substrate, the membrane spanning across a plurality of pores on the porous substrate to form a plurality of cavities having sufficient geometry to permit entry of assay reagents into each cavity, thereby allowing access of assay reagents to both sides of GPCR in the membrane.

Abstract: A conversion method for converting a unipolar voltage data stream into a carrier-suppressed return-to-zero (CSRZ) optical data stream includes modulating a continuous optical wave with an encoded nonreturn-to-zero (NRZ) voltage data stream for providing a CSRZ optical data stream of full-width at half-maximum (FWHM) pulse width less than one-half of the transition time of the encoded nonreturn-to-zero (NRZ) voltage data stream between logical states for a reduced pulse width. The modulating circuit is either a duobinary modulator driven with a swing of ±2V? or an optical time domain multiplexed plurality of nonreturn-to-zero (NRZ) modulators with phase shifting and differential encoding.

Abstract: A conversion method for converting a unipolar voltage data stream into a carrier-suppressed return-to-zero (CSRZ) optical data stream includes modulating a continuous optical wave with an encoded nonreturn-to-zero (NRZ) voltage data stream for providing a CSRZ optical data stream of full-width at half-maximum (FWHM) pulse width less than one-half of the transition time of the encoded nonreturn-to-zero (NRZ) voltage data stream between logical states for a reduced pulse-width. The modulating circuit is either a duobinary modulator driven with a swing of ±2V&pgr; or an optical time domain multiplexed plurality of nonreturn-to-zero (NRZ) modulators with phase shifting and differential encoding.

Abstract: A device (16) in a system (10) modulates an optical signal (13) and tunes the duty cycle of the optical signal (13) for optimizing system performance as a response of the duty cycle. The device (16) includes a tunable duty-cycle Mach-Zehnder interferometer (MZI) acting as a pulse-width shaper (160) for modulating the optical signal (13) and tuning the duty cycle of the optical signal (13). The MZI (160) has a transmittance transfer function of the interferometer (160). At least one electrode structure (163) generates a DC voltage and an AC voltage for biasing and controlling the swing of the Mach-Zehnder interferometer (160) with the respective amplitudes of the DC and AC voltages such that the maximum power transmittance point on the transfer function is less than 100% for tuning the duty cycle of the optical signal (13) such that system performance is optimized.

Abstract: A device (16) in a system (10) modulates an optical signal (13) and tunes the duty cycle of the optical signal (13) for optimizing system performance as a response of the duty cycle. The device (16) includes a tunable duty-cycle Mach-Zehnder interferometer (MZI) acting as a pulse-width shaper (160) for modulating the optical signal (13) and tuning the duty cycle of the optical signal (13). The MZI (160) has a transmittance transfer function of the interferometer (160). At least one electrode structure (163) generates a DC voltage and an AC voltage for biasing and controlling the swing of the Mach-Zehnder interferometer (160) with the respective amplitudes of the DC and AC voltages such that the maximum power transmittance point on the transfer function is less than 100% for tuning the duty cycle of the optical signal (13) such that system performance is optimized.