Patents by Inventor Srikanth Vedamoorthy
Srikanth Vedamoorthy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10613083Abstract: A biosensor system for the detection of target analytes that includes a living biological cell of a predetermined type; a signal-generating reporter associated with the living biological cell; a signal transduction pathway or other activator mechanism or means associated with the signal-generating reporter; a universal detector element associated with the activator mechanism; and an analyte binding element associated with the universal detector element, wherein the analyte binding element is specific to both the universal detector element and a target analyte.Type: GrantFiled: December 20, 2017Date of Patent: April 7, 2020Assignee: Fundamental Solutions CorporationInventors: Thomas J. Zupancic, Joseph D. Kittle, Lingchun Zeng, Srikanth Vedamoorthy, Richard S. Brody, Marvin R. Williams
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Patent number: 10550178Abstract: An isolated antibody, consisting of an anti-glutathionylated eNOS antibody, wherein the anti-glutathionylated eNOS antibody has been generated against an immunogen consisting of a peptide that includes glutathione; a first linker; an eNOS peptide; a second linker; and a T-cell epitope; and wherein the anti-glutathionylated eNOS antibody is adapted to recognize redox modulated eNOS proteins.Type: GrantFiled: August 30, 2018Date of Patent: February 4, 2020Inventor: Srikanth Vedamoorthy
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Publication number: 20180371070Abstract: An isolated antibody, consisting of an anti-glutathionylated eNOS antibody, wherein the anti-glutathionylated eNOS antibody has been generated against an immunogen consisting of a peptide that includes glutathione; a first linker; an eNOS peptide; a second linker; and a T-cell epitope; and wherein the anti-glutathionylated eNOS antibody is adapted to recognize redox modulated eNOS proteins.Type: ApplicationFiled: August 30, 2018Publication date: December 27, 2018Inventor: Srikanth VEDAMOORTHY
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Patent number: 10066006Abstract: Disclosed embodiments relate to antibodies that recognize redox modulated proteins such as glutathionylated actin. Embodiments relate to a reagent for the immunoassay of glutathionylated actin. Disclosed embodiments also relate to diagnosis of and therapies for the treatment of diseases related to impaired deglutathionylation of peptides. Additionally, disclosed embodiments relate to pharmaceutical compositions containing antibodies which recognize redox modulated proteins and kits for the detection or treatment of diseases related to redox modulated proteins which include antibodies that recognize redox modulated proteins.Type: GrantFiled: June 29, 2015Date of Patent: September 4, 2018Inventor: Srikanth Vedamoorthy
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Publication number: 20180180608Abstract: A biosensor system for the detection of target analytes that includes a living biological cell of a predetermined type; a signal-generating reporter associated with the living biological cell; a signal transduction pathway or other activator mechanism or means associated with the signal-generating reporter; a universal detector element associated with the activator mechanism; and an analyte binding element associated with the universal detector element, wherein the analyte binding element is specific to both the universal detector element and a target analyte.Type: ApplicationFiled: December 20, 2017Publication date: June 28, 2018Inventors: Thomas J. ZUPANCIC, Joseph D. KITTLE, Lingchun ZENG, Srikanth VEDAMOORTHY, Richard S. BRODY, Marvin R. WILLIAMS
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Patent number: 9850546Abstract: A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineerType: GrantFiled: July 6, 2017Date of Patent: December 26, 2017Assignee: Fundamental Solutions CorporationInventors: Thomas J. Zupancic, Lingchun Zeng, Srikanth Vedamoorthy, Joel S. Lwande, Joseph D. Kittle, Min Mo
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Patent number: 9850548Abstract: A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineerType: GrantFiled: July 6, 2017Date of Patent: December 26, 2017Assignee: Fundamental Solutions CorporationInventors: Thomas J. Zupancic, Lingchun Zeng, Srikanth Vedamoorthy, Joel S. Lwande, Joseph D. Kittle, Min Mo
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Patent number: 9850547Abstract: A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineerType: GrantFiled: July 6, 2017Date of Patent: December 26, 2017Assignee: Fundamental Solutions CorporationInventors: Thomas J. Zupancic, Lingchun Zeng, Srikanth Vedamoorthy, Joel S. Lwande, Joseph D. Kittle, Min Mo
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Publication number: 20170306424Abstract: A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineerType: ApplicationFiled: July 6, 2017Publication date: October 26, 2017Inventors: Thomas J. ZUPANCIC, Lingchun ZENG, Srikanth VEDAMOORTHY, Joel S. LWANDE, Joseph D. KITTLE, Min MO
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Publication number: 20170306423Abstract: A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineerType: ApplicationFiled: July 6, 2017Publication date: October 26, 2017Inventors: Thomas J. ZUPANCIC, Lingchun ZENG, Srikanth VEDAMOORTHY, Joel S. LWANDE, Joseph D. KITTLE, Min MO
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Publication number: 20170306422Abstract: A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineerType: ApplicationFiled: July 6, 2017Publication date: October 26, 2017Inventors: Thomas J. ZUPANCIC, Lingchun ZENG, Srikanth VEDAMOORTHY, Joel S. LWANDE, Joseph D. KITTLE, Min MO
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Patent number: 9752199Abstract: A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineerType: GrantFiled: March 31, 2016Date of Patent: September 5, 2017Assignee: Fundamental Solutions CorporationInventors: Thomas J. Zupancic, Lingchun Zeng, Srikanth Vedamoorthy, Joel S. Lwande, Joesph D. Kittle, Min Mo
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Publication number: 20160289775Abstract: A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineerType: ApplicationFiled: March 31, 2016Publication date: October 6, 2016Applicant: FUNDAMENTAL SOLUTIONS CORPORATIONInventors: Thomas J. ZUPANCIC, Lingchun ZENG, Srikanth VEDAMOORTHY, Joel S. LWANDE, Joesph D. KITTLE
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Publication number: 20150291687Abstract: Disclosed embodiments relate to antibodies that recognize redox modulated proteins such as glutathionylated actin. Embodiments relate to a reagent for the immunoassay of glutathionylated actin. Disclosed embodiments also relate to diagnosis of and therapies for the treatment of diseases related to impaired deglutathionylation of peptides. Additionally, disclosed embodiments relate to pharmaceutical compositions containing antibodies which recognize redox modulated proteins and kits for the detection or treatment of diseases related to redox modulated proteins which include antibodies that recognize redox modulated proteins.Type: ApplicationFiled: June 29, 2015Publication date: October 15, 2015Inventor: Srikanth Vedamoorthy
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Patent number: 9067982Abstract: Disclosed embodiments relate to antibodies that recognize redox modulated proteins such as glutathionylated actin. Embodiments relate to a reagent for the immunoassay of glutathionylated actin. Disclosed embodiments also relate to diagnosis of and therapies for the treatment of diseases related to impaired deglutathionylation of peptides. Additionally, disclosed embodiments relate to pharmaceutical compositions containing antibodies which recognize redox modulated proteins and kits for the detection or treatment of diseases related to redox modulated proteins which include antibodies that recognize redox modulated proteins.Type: GrantFiled: March 18, 2011Date of Patent: June 30, 2015Inventor: Srikanth Vedamoorthy
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Publication number: 20140335603Abstract: A system for detecting infectious agents in biological samples in real time that includes a sample to be tested for at least one specific infectious agent; and a biosensor, wherein the biosensor is operative to detect a specific infectious agent in the sample to be tested; and wherein the biosensor emits an amplified and detectable signal when it reacts with the specific infectious agent. Signal detection is enhanced through the release of LPS from the cells of the infectious agent.Type: ApplicationFiled: March 13, 2014Publication date: November 13, 2014Applicant: APPLIED BIOMOLECULAR TECHNOLOGIESInventors: Thomas J. ZUPANCIC, J.D. KITTLE, Lingchun ZENG, Srikanth VEDAMOORTHY, Min MO
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Publication number: 20140273020Abstract: A system for detecting infectious agents in biological samples in real time that includes a sample to be tested for at least one specific infectious agent; and at least one biosensor, wherein the biosensor is operative to detect a specific infectious agent in the sample to be tested; wherein the biosensor emits a detectable signal when it reacts with the specific infectious agent; wherein the biosensor is a hybridoma cell that naturally expresses an endogenous anti-target antigen specific IgM; and wherein the hybridoma cell has been converted to a B cell receptor biosensor by introducing a detectable reporter gene into the cell.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: APPLIED BIOMOLECULAR TECHNOLOGIESInventors: Thomas J. ZUPANCIC, J.D. Kittle, Lingchun Zeng, Srikanth Vedamoorthy, Min Mo
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Publication number: 20110230649Abstract: Disclosed embodiments relate to antibodies that recognize redox modulated proteins such as glutathionylated actin. Embodiments relate to a reagent for the immunoassay of glutathionylated actin. Disclosed embodiments also relate to diagnosis of and therapies for the treatment of diseases related to impaired deglutathionylation of peptides. Additionally, disclosed embodiments relate to pharmaceutical compositions containing antibodies which recognize redox modulated proteins and kits for the detection or treatment of diseases related to redox modulated proteins which include antibodies that recognize redox modulated proteins.Type: ApplicationFiled: March 18, 2011Publication date: September 22, 2011Applicant: NITAN BIOTECH LLCInventor: Srikanth Vedamoorthy