Patents by Inventor Srikrishna Apar

Srikrishna Apar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of Degarelix acetate and Degarelix acetate-mannitol premix
    Patent number: 11332495
    Abstract: Methods for preparing degarelix acetate are provided that include the steps of providing a suitable resin; deprotecting the resin with a diethylenetriamine solution; reacting sequentially the deprotected resin with different Fmoc protected amino acids; deprotecting the amino acid in each sequence with a diethylenetriamine solution in a stepwise fashion to yield a degarelix crude compound; and purifying the degarelix crude compound to yield pharmaceutically acceptable degarelix acetate. Methods of preparing degarelix acetate-mannitol premix and the resulting degarelix acetate-mannitol premix are also provided.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: May 17, 2022
    Assignee: RK PHARMA SOLUTIONS LLC
    Inventors: Ravishanker Kovi, Jayaraman Kannappan, Sai Saisuryanarayana Donthukurthi, Shivam Saroj, Piyush Fadadu, Srikrishna Apar, Sandeep Aher, Veerabhadra Rao Bobbili
  • PROCESS FOR THE PREPARATION OF FERRIC CITRATE
    Publication number: 20210332073
    Abstract: Method are provided for obtaining ferric citrate that includes the step(s) of reacting ferric chloride with a suitable base to obtain ferric hydroxide; reacting the ferric hydroxide with citric acid to obtain ferric citrate; and processing the ferric citrate to obtain ferric citrate. The resulting ferric citrate has a specific surface area greater than 16 sq. m/g, but less than 20 sq. m/g.
    Type: Application
    Filed: September 28, 2020
    Publication date: October 28, 2021
    Inventors: Ravishanker Kovi, Jayaraman Kannappan, Shivnath Patil, Srikrishna Apar, Govind Ahirrao, Shrikant Wadajkar
  • Process for the preparation of Degarelix acetate and Degarelix acetate-mannitol premix
    Publication number: 20210094984
    Abstract: Methods for preparing degarelix acetate are provided that include the steps of providing a suitable resin; deprotecting the resin with a diethylenetriamine solution; reacting sequentially the deprotected resin with different Fmoc protected amino acids ;deprotecting the amino acid in each sequence with a diethylenetriamine solution in a stepwise fashion to yield a degarelix crude compound; and purifying the degarelix crude compound to yield pharmaceutically acceptable degarelix acetate.
    Type: Application
    Filed: September 15, 2020
    Publication date: April 1, 2021
    Inventors: Ravishanker Kovi, Jayaraman Kannappan, Sai Saisuryanarayana Donthukurthi, Shivam Saroj, Piyush Fadadu, Srikrishna Apar, Sandeep Aher, Veerabhadra Rao Bobbili