Patents by Inventor Srikumar CHELLAPAN

Srikumar CHELLAPAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4
    Publication number: 20190375709
    Abstract: Binding of the transcriptional co-activator, YAP1, to the transcription factor Oct4, induces Sox2. which is a transcription actor necessary for the self-renewal of stem-like cells from non-small cell lung cancer. The WW domain of YAP1 binds to the PPxY motif of Oct4 to induce Sox2. Delivering a peptide corresponding to the WAV domain could prevent the induction of Sox2 and stemness. Similarly, peptides and mimetics of the PPxY motif would be able to inhibit stemness. Disclosed arc compounds that affect the Yap1:Oct4 interaction.
    Type: Application
    Filed: September 18, 2017
    Publication date: December 12, 2019
    Inventors: Srikumar CHELLAPAN, Nicholas J. LAWRENCE, Sujeewa Ranatunga Mahanthe MUDIYANSELAGE