Abstract: The present disclosure relates to methods for treating cancer in patients having low expression of MHC Class I genes, and in patients having increased serum levels of PD-L2 by administration of a TLR9 agonist.

Abstract: The present invention is directed to use of tilsotolimod in the treatment of coronavirus infection, for example, SARS-CoV2, and COVID-19.

Abstract: A method of diagnosing and treating proliferative disorders in connection with the use of a Smac mimetic.

Abstract: A combination therapy comprising administration of a Smac mimetic and GM-CSF.

Abstract: A method of using a Smac mimetic and pharmaceutical compositions thereof.

Abstract: A Smac mimetic therapy wherein the Smac mimetic is selected and developed based at least in part on its cIAP degradation properties.

Abstract: Embodiments of a multi-piece centrifugal impeller are provided, as are embodiments of a method for manufacturing a multi-piece centrifugal impeller. In one embodiment, the centrifugal impeller includes an inducer piece and an exducer piece. The inducer piece includes, in turn, an inducer hub and a plurality of forward blade segments, which extend radially outward from the inducer hub. The exducer piece includes an exducer hub, which is positioned axially adjacent the inducer hub, and a plurality of aft blade segments, which extending outward from the exducer hub. The plurality of aft blade segments interlock with the plurality of forward blade segments to form a plurality of contiguous blade structures, which extend from a forward portion of the inducer hub to an aft portion of the exducer hub.

Abstract: According to the present invention mechanical system for tilting cab of a vehicle, the rotational motion of the detachable handle (12) is transmitted to the worm shaft (14) through the engaging clip (15). The worm shaft (14) rotates the worm (11) which in turn rotates the nut (10). The nut (10) being restrained for translational motion, pushes the screw (9) upward. The screw (9) gets a translational motion and is raised. The clevis joint (8) on the top of the screw (9) forces the link arm (7) upwards. The link arm (7) also rotates about the clevis joint (8) due to the revolute joint. The link arm (7) transmits this motion through the bush (13) and the bush bracket (6) to the suspension bracket (3) of the cab (1). As a result the cab (1) tilts about its transverse axis (5).

Abstract: According to the present invention mechanical system for tilting cab of a vehicle, the rotational motion of the detachable handle (12) is transmitted to the worm shaft (14) through the engaging clip (15). The worm shaft (14) rotates the worm (11) which in turn rotates the nut (10). The nut (10) being restrained for translational motion, pushes the screw (9) upward. The screw (9) gets a translational motion and is raised. The clevis joint (8) on the top of the screw (9) forces the link arm (7) upwards. The link arm (7) also rotates about the clevis joint (8) due to the revolute joint. The link arm (7) transmits this motion through the bush (13) and the bush bracket (6) to the suspension bracket (3) of the cab (1). As a result the cab (1) tilts about its transverse axis (5).

Abstract: The present invention is directed to compounds, compositions and methods for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus. Also within the scope of this invention are assay methods for identifying agents that modulate NS4B activity, as well as kits for performing such methods.

Abstract: Pyridine derivatives that exhibit antiviral activity are disclosed.