Patents by Inventor Srinivas K. Chunduru

Srinivas K. Chunduru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Smac Mimetic Therapy
    Publication number: 20140303090
    Abstract: A Smac mimetic therapy wherein the Smac mimetic is selected and developed based at least in part on its poor inhibition of XIAP-dependent processes.
    Type: Application
    Filed: April 7, 2014
    Publication date: October 9, 2014
    Applicant: TETRALOGIC PHARMACEUTICALS CORPORATION
    Inventors: Stephen M. Condon, Srinivas K. Chunduru, Yasuhiro Mitsuuchi, James Vince, John Silke
  • METHOD OF TREATMENT
    Publication number: 20110287001
    Abstract: The invention provides methods for inducing apoptosis, comprising treatment of a patient with a TNF? inhibitor as well as with an IAP inhibitor and a TRAIL receptor agonist. The methods ameliorate the risk of unwanted effects, thereby resulting in an improved therapeutic index for IAP inhibitors in combination with a TRAIL receptor agonist.
    Type: Application
    Filed: August 5, 2009
    Publication date: November 24, 2011
    Applicants: TETRALOGIC PHARMACEUTICALS, AMGEN INC.
    Inventors: Pamela M. Holland, Julia C. Piasecki, Christopher A. Benetatos, Srinivas K. Chunduru, Mark A. McKinlay
  • TNFalpha GENE EXPRESSION AS A BIOMARKER OF SENSITIVITY TO ANTAGONISTS OF INHIBITOR OF APOPTOSIS PROTEINS
    Publication number: 20110008802
    Abstract: TNF? gene expression can be used as a biomarker of a cell's sensitivity to antagonists of inhibitor of apoptosis proteins (IAPs). Methods of the invention are useful for screening patients to identify those who could benefit from administration of an IAP antagonist to treat various malignant or benign tumors, benign proliferative diseases, or autoimmune diseases.
    Type: Application
    Filed: May 7, 2008
    Publication date: January 13, 2011
    Applicant: TETRALOGIC PHARMACEUTICALS CORP.
    Inventors: Alireza Alavi, Mark A. McKinlay, Srinivas K. Chunduru, John Silke, David Vaux, James Vince