Patents by Inventor Srinivas Olepu

Srinivas Olepu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 11535630
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: December 27, 2022
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 10954247
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: March 23, 2021
    Assignee: Research Triangle Institute
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20210070767
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: October 28, 2020
    Publication date: March 11, 2021
    Inventors: Scott P. RUNYON, Rangan MAITRA, Sanju NARAYANAN, James Barnwell THOMAS, Kenneth S. REHDER, Srinivas OLEPU
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 10100059
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: October 16, 2018
    Assignee: Research Triangle Institute
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20180265518
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: May 18, 2018
    Publication date: September 20, 2018
    Inventors: Scott P. RUNYON, Rangan MAITRA, Sanju NARAYANAN, James Barnwell THOMAS, Kenneth S. REHDER, Srinivas OLEPU
  • PYRAZOLE COMPOUNDS SELECTIVE FOR NEUROTENSIN 2 RECEPTOR
    Publication number: 20170174633
    Abstract: This invention relates generally to the discovery of pyrazole compounds selective for the neurotensin receptor 2 (NTR2) and uses thereof.
    Type: Application
    Filed: March 24, 2015
    Publication date: June 22, 2017
    Inventors: James B. THOMAS, Brian P. GILMOUR, Angela M. GIDDINGS, Robert W. WIETHE, Keith R. WARNER, Srinivas OLEPU
  • APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20170166577
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: December 9, 2016
    Publication date: June 15, 2017
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • C8—linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids
    Patent number: 7056913
    Abstract: The present invention provides novel pyrrolo-[2,1-c][1,4]benzodiazepine hybrids useful as anti-tumour agents and a process for the preparation thereof.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: June 6, 2006
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Srinivas Olepu, Ramulu Poddutoori, Ramesh Gujjar, Praveen Kumar Pogula
  • PROCESS FOR PREPARING PYRROLO[2, 1-C] [1,4] BENZODIAZEPINE HYBRIDS
    Publication number: 20050222133
    Abstract: Novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids as well as processes for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids are dislcosed. More particularly, present invention relates to a process for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids as DNA sequence selective agents which are useful as potential antitumour agents. In particular, the present invention relates to a process for the preparation of new pyrrolo [2,1-c][1,4]benzodiazepine hybrids as potential antitumour agents.
    Type: Application
    Filed: March 30, 2004
    Publication date: October 6, 2005
    Inventors: Ahmed Kamal, Ramulu Poddutoori, Srinivas Olepu
  • C8 - linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids
    Publication number: 20050222132
    Abstract: The present invention provides novel pyrrolo-[2,1-c][1,4]benzodiazepine hybrids useful as anti-tumour agents and a process for the preparation thereof.
    Type: Application
    Filed: March 30, 2004
    Publication date: October 6, 2005
    Inventors: Ahmed Kamal, Srinivas Olepu, Ramulu Poddutoori, Ramesh Gujjar, Praveen Pogula
  • Process for preparing pyrrolo[2, 1-c] [1,4] benzodiazepine hybrids
    Patent number: 6951853
    Abstract: Novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids as well as processes for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids are dislcosed. More particularly, present invention relates to a process for the preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine hybrids as DNA sequence selective agents which are useful as potential antitumour agents. In particular, the present invention relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential antitumour agents.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: October 4, 2005
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Ramulu Poddutoori, Srinivas Olepu
  • Pyrene-linked pyrrolo[2,1-c][1,4]benzodiazepine hybrids useful as anti-cancer agents
    Patent number: 6800622
    Abstract: The present invention relates to a process for the preparation of novel pyrrolo [2,1-c][1,4]benzodiazepine hybrids useful as antitumour agents. This invention also relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential antitumour agents. More particularly, it provides a process for the preparation of 7-methoxy-8-[N-(1″-pyrenyl)-alkane-3′-carboxamide]-oxy-(11aS)-1,2,3,11a-tetraydro 5H-pyrrolo[2,1-c][1,4]benzodiazepine-5-one, with aliphatic chain length variation of these compounds and it also describes the DNA binding, anticancer (antitumour) activity.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: October 5, 2004
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Ramesh Gujjar, Ramulu Poddutoori, Srinivas Olepu
  • PYRENE-LINKED PYRROLO[2,1--C][1,4]BENZODIAZEPINE HYBRIDS USEFUL AS ANTI-CANCER AGENTS
    Publication number: 20040192677
    Abstract: The present invention relates to a process for the preparation of novel pyrrolo [2,1 -c][1,4]benzodiazepine hybrids useful as antitumour agents. This invention also relates to a process for the preparation of new pyrrolo[2,1-c][1,4]benzodiazepine hybrids as potential antitumour agents. More particularly, it provides a process for the preparation of 7-methoxy-8-[N-(1″-pyrenyl)-alkane-3′-carboxamide]-oxy-(11aS)-1,2,3,11a-tetraydro 5H-pyrrolo[2,1 -c][1,4]benzodiazepin-5-one, with aliphatic chain length variation of these compounds and it also describes the DNA binding, aticancer (antitumour) activity.
    Type: Application
    Filed: March 25, 2003
    Publication date: September 30, 2004
    Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
    Inventors: Ahmed Kamal, Ramesh Gujjar, Ramulu Poddutoori, Srinivas Olepu
  • Process for the preparation of antitumor agents
    Patent number: 6362331
    Abstract: The present invention provides a process for the preparation of a novel pyrrolo[2,1-c][1,4]benzodiazepine of formula VI wherein R is H, OII, OAc and R1 is H, and n is 3 to 5, by reacting (2S)-N-[4-hydroxy-5-methoxy-2-nitrobenzyl]-pyrrolidine-2-carboxy-carbaldehyde diethyl thioacetal with a dibromoalkane, isolating (2S)-N-[4-(3-bromoalkoxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxy carbaldehyde diethyl thioacetal so formed and reacting the isolate with a dilactam, isolating 8-{[(2S)-N-5-methoxy-2-nitrobenzoyl]pyrrolidin-2-carbaldehyde diethylthioacetal}-alkoxy-7-methoxy-2,3,5,10,11,11a-hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11 dione, reducing the above nitro compound, isolating the 8-{[(2S)-N-5-methoxy-2-aminobenzoyl]pyrrolidin-2-carbaldehyde diethylthioacetal]-alkoxy-7-methoxy-2,3,5,10,11,11a-hydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione, reacting the ami
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: March 26, 2002
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Chakravarthy Laxman Nallan, Ramesh Gujjar, Ramulu Poddutoori, Srinivas Olepu
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: RE49594
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: August 1, 2023
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu