Abstract: A process for the dry granulation and manufacture of a pharmaceutical formulation comprises the steps of adding sodium phenytoin to a vessel of a mixer/granulator and adding at least one excipient to the vessel. Heat is then applied from the vessel to the sodium phenytoin and excipient to achieve the desired target temperature. Next, while the heat is applied from the vessel, the sodium phenytoin and excipient are mixed and chopped in the vessel to form a granulation suitable for encapsulating into a dosage form. Preferably, the excipients include magnesium stearate, sugar, lactose monohydrate, and talc. In an alternative embodiment, talc is added after chopping and blended into the formulation to form a blend suitable for encapsulating into a dosage form.

Abstract: A device, system and method for bypassing and/or testing a sample of a material flowing in a direction along a flowpath utilizes a sleeve having open ends and defining a duct adapted for insertion into the flowpath and a sidewall. An inlet conduit attached to the sleeve has an inlet section at one end, and an outlet conduit attached to the sleeve has an outlet section. The sample is returned through the outlet conduit in a direction substantially parallel to the direction of the material flowing through the sleeve.