Abstract: The present invention relates to a process for the preparation of 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3?,4?:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluoro-phenyl)-butan-1-one represented by the following structural formula-1 and pharmaceutically acceptable salts thereof. The present invention further relates to processes for the preparation of intermediates of 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3?,4?:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluoro-phenyl)-butan-1-one compound of formula-1. The present invention further relates to novel intermediates of 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3?,4?:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluoro-phenyl)-butan-1-one compound of formula-1 and process for preparation thereof.

Abstract: A vehicle includes a vehicle seat and a plate fixed relative to the vehicle seat. A seatbelt buckle is rotatably supported by the vehicle seat. The seatbelt buckle is rotatable relative to the plate from a first position to a second position. A slot is in one of the plate and the seatbelt buckle and a pin is supported by the other of the plate and the seatbelt buckle. The pin is moveable relative to the other of the plate and the seatbelt buckle from a retracted position to an extended position. The pin is spaced from the slot and in the retracted position when the seatbelt buckle is in the first position. The pin is in the extended position and extends into the slot when the seatbelt buckle is in the second position. A pyrotechnic device is operatively coupled to the seatbelt buckle to rotate the seatbelt buckle.

Abstract: A device for inductively charging an electronic accessory includes a first portion, a second portion, and a spacer. The first portion includes a first transmission coil in a first plane where the first transmission coil is configured to generate a first magnetic field, and the second portion includes a first transmission coil in a second plane where the second transmission coil is configured to generate a second magnetic field. The spacer is positioned between the first transmission coil and the second transmission coil and between the first plane and the second plane. The spacer material magnetically insulates the second transmission coil from the first magnetic field.

Abstract: Systems and methods for repositioning autonomous vehicles are disclosed. The systems and methods facilitate moving vehicles of a fleet of vehicles into more advantageous locations. For example, autonomous vehicles can be moved from positions where a vehicle would be difficult to access by a user and/or be less likely to be used by a user to positions that provide easier access by a user and/or make the vehicle more likely to be used.

Abstract: A vehicle includes a vehicle seat and a plate fixed relative to the vehicle seat. A seatbelt buckle is rotatably supported by the vehicle seat. The seatbelt buckle is rotatable relative to the plate from a first position to a second position. A slot is in one of the plate and the seatbelt buckle and a pin is supported by the other of the plate and the seatbelt buckle. The pin is moveable relative to the other of the plate and the seatbelt buckle from a retracted position to an extended position. The pin is spaced from the slot and in the retracted position when the seatbelt buckle is in the first position. The pin is in the extended position and extends into the slot when the seatbelt buckle is in the second position. A pyrotechnic device is operatively coupled to the seatbelt buckle to rotate the seatbelt buckle.

Abstract: A vehicle includes a vehicle seat and a plate fixed relative to the vehicle seat. A seatbelt buckle is rotatably supported by the vehicle seat and is rotatable relative to the plate to one of a first or second position. A first and second slot are both in one of the plate or the seatbelt buckle. A pin supported by and movable to an extended position relative to one of the plate or the seatbelt buckle. The pin is spaced from the first and second slot when the seatbelt buckle is in a stowed position and is positioned to extend into the first or second slot when the seatbelt buckle is in the first or second position. A computer executes instructions to rotate the seatbelt buckle to one of the first or second position based on a size of an occupant and, then, move the pin to the extended position.

Abstract: A vehicle includes a vehicle roof and a liftgate pivotable relative to the vehicle roof between an open position and a closed position. The vehicle includes an airbag supported by the liftgate and moveable with the liftgate between the open position and the closed position. A tether is fixed to the airbag and the liftgate. The tether extends from the airbag vehicle-rearward to the liftgate.

Abstract: A handheld portable oxygen monitor for monitoring oxygen includes one or more of (1) a replaceable dust filter element removably disposed in a gas inlet pathway extending from an gas inlet port to an oxygen sensor, (2) an oxygen sensor module including the oxygen sensor and a circuit board on which the oxygen sensor is mounted, the oxygen sensor module being removably mounted to a circuit board holder, (3) configurable gas pathway components within the oxygen monitor housing, and (4) a controller operable to enable a remote device to (a) control one or more operations of the oxygen monitor, (b) receive real-time oxygen monitoring data from the oxygen monitor for display on the remote device, (c) upload logging event data from the oxygen monitor storage, (d) obtain system information from the oxygen monitor storage, and (e) perform firmware updates on the oxygen monitor to modify its programming.

Abstract: Systems and methods provide for an automated system for determining whether claims related to an insured item should proceed to an arbitrating body. A virtual assistant (also referred to herein as an “arbitration assessment assistant”) installed in a computing device (e.g., computer, laptop, tablet computer, mobile phone, etc.) may be responsible for managing and assisting an insurance representative (e.g., an insurance adjuster, subrogation representative, etc.) in determining liability and fault relating to a claim, conducting a subrogation process, and ultimately determining whether the claim should be submitted for arbitration. In one or more aspects discussed, herein the process may be fully automated.

Abstract: A computing device obtains data indicating a topography for an area comprising water and receives an indication of an identified data object representing a stressor to the area or a first monitoring station configurable to monitor the stressor. The computing device also determines a location for the identified data object in the topography and selects one or more related data objects to be related to the identified data object by determining a classification indicating whether the identified data object operates in water and selecting the one or more related data objects based on the location and the classification. The computing device also generates one or more controls for monitoring the area based on the selected one or more related data objects.

Abstract: The present invention discloses a preform assembly and a method for drawing a multicore optical fibre and a holey fibre. Particularly, the preform assembly includes a hollow cylindrical tube, a plurality of discs stacked inside the hollow cylindrical tube and a plurality of core rods inserted in a plurality of through holes in each of the plurality of discs.

Abstract: The present invention relates to a method (300) for drawing an optical fiber (101) having step of stacking (302) at least two glass sub-preforms of a plurality of glass sub-preforms (114a-114n) inside a hollow cylindrical glass tube (108) to form a master glass preform (130) and melting (304) the bottom end (134) of the master glass preform (130) in a furnace (110) to continuously draw an optical fiber (101). In particular, the at least two glass sub-preforms are stacked in such that the master glass preform has a top end (132) and a bottom end (134) and each of the glass sub-preforms is defined by a first end (126) and a second end (128). Further, the first end (126) of a successive glass sub-preform is stacked on the second end (128) of a previous glass sub-perform such that the successive glass sub-preform rests on the previous glass sub-preform.

Abstract: A vehicle includes a vehicle seat having a first side and a second side spaced cross-seat from each other. A seatbelt buckle is fixed to the first side. A seatbelt assembly includes a latch plate engageable with the seatbelt buckle and a webbing having a lap portion defined by the latch plate when the latch plate is engaged with the seatbelt buckle. A hook is retractably supported by the second side of the vehicle seat. The hook is retractable relative to the vehicle seat from a first position to a retracted position. The hook is engageable with the lap portion of the webbing as the hook retracts. A lock includes a pin engageable with the hook when the hook is in the first position and the retracted position. A spring biases the pin toward the hook. A pyrotechnic device is operatively coupled to the lock to disengage the pin from the hook.

Abstract: Systems and methods for repositioning autonomous vehicles are disclosed. The systems and methods facilitate moving vehicles of a fleet of vehicles into more advantageous locations. For example, autonomous vehicles can be moved from positions where a vehicle would be difficult to access by a user and/or be less likely to be used by a user to positions that provide easier access by a user and/or make the vehicle more likely to be used.

Abstract: Provided herein are IL-12p40 and IL-12p35 polypeptides and compositions (e.g., pharmaceutical compositions) comprising the same; as well as methods of making the IL-12p40 and IL-12p35 polypeptides and compositions. Further provided herein are fusion proteins (e.g., antibody fusion proteins) that comprise an IL-12p40 polypeptide (e.g., an IL-12p40 polypeptide described herein) and/or IL-12p35 polypeptide (e.g., an IL-12p35 polypeptide described herein). The IL-12p40 polypeptides, IL-12p35 polypeptides, and fusion proteins provided herein are useful in pharmaceutical compositions and methods of treating diseases (e.g., cancer).

Abstract: A vehicle includes a vehicle roof and a liftgate pivotable relative to the vehicle roof between an open position and a closed position. The vehicle includes an airbag supported by the liftgate and moveable with the liftgate between the open position and the closed position. A tether is fixed to the airbag and the liftgate. The tether extends from the airbag vehicle-rearward to the liftgate.

Abstract: Provided herein are methods comprising the use of KRAS (e.g., hKRAS) inhibitors in combination with an agent(s) that specifically binds to EGFR (e.g., hEGFR) and TGF? (e.g., hTGF?), as well as compositions and kits comprising the same. The methods provided herein are useful in methods of treating cancer, (e.g., KRAS (e.g., hKRAS) variant cancers). Further provided herein are combination regimens, combination compositions, pharmaceutical compositions, and kits comprising a KRAS (e.g., hKRAS) inhibitor and an agent(s) that specifically binds to EGFR (e.g., hEGFR) and TGF? (e.g., hTGF?).

Abstract: Systems and methods of reconstructing execution call flows to detect anomalies are provided. A device can establish call flows using information extracted from a log file. Each of the call flows can identify information from the log file of a call flowing through a plurality of modules. The device can identify a count of a number of occurrences of one or more keywords in information of each call flow. The device can generate a vector of numbers for each call flow based at least on the count for the one or more keywords for that call flow. The device can classify each call flow into one or more clusters that indicate whether an operation of the call flow is anomalous. The device can classify each call flow using the vector of numbers for each call flow.

Abstract: The invention describes an efficient platform for antibody manufacturing and formulation that provides i) cell culture process with improved feeding strategy resulting in high antibody titer between 2 gm/L to 5 gm/L; ii) improved purification process showing optimal percentage recovery, high purity monomer content, minimum aggregation/particulate formation, minimum impurity levels; and iii) high concentration stable liquid formulation with optimal osmolality and low viscosity across different temperature excursions and devoid of aggregation. The preferred antibodies include IgG1 monoclonal antibody specific to the Dengue virus epitope in domain III of the E protein and IgG1 monoclonal antibody specific to the rabies virus surface G glycoprotein.

Abstract: The present invention relates to a method (200, 400, 500, 600) for drawing a bare optical fiber (118) from a cylindrical glass preform (102) in a furnace chamber (104) by hanging the cylindrical glass preform (102) near a first end (104a) of the furnace chamber (104), injecting first and second inert gasses inside the furnace chamber (104) in a predefined ratio of 0.3 to 5, and melting the cylindrical glass preform (102) while maintaining a positive pressure in the furnace chamber (104) to form the bare optical fiber (118) such that a Bare Fiber Diameter (BFD) variation of the bare optical fiber (118) is less than 0.1 micrometers (?m) from a mean diameter of the bare optical fiber (118).