Patents by Inventor Srinivasa Madhyastha
Srinivasa Madhyastha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11723852Abstract: Compositions comprising one or more chelating agents and optionally zinc ion salts are used to inhibit the growth or biofilm formation in bacteria associated with personal care products such as ophthalmic, pedicure, manicure or podiatric solutions. The compositions of the present application can also comprise gelling agents, antimicrobials, antibiotic or a pH adjuster. The compositions may be in the form of a solution, a gel, a cream, a jelly, a powder, a paste, a lotion, soap and a cleaner.Type: GrantFiled: August 3, 2021Date of Patent: August 15, 2023Assignee: KANE BIOTECH INC.Inventors: Purushottam V. Gawande, Karen Lovetri, Nandadeva Yakandawala, Gord Froehlich, Srinivasa Madhyastha
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Patent number: 11648259Abstract: Mycotoxin-deactivating aptamers, especially DNA aptamers, bind to mycotoxins in feed and feed ingredients resulting in the reduction or elimination of toxic and carcinogenic effects of mycotoxins. The invention also discloses a composition comprising a mycotoxin-deactivating aptamer, a binding agent, a biotransforming agent and an antioxidant for detoxifying mycotoxins in feeds. In addition, the invention teaches the methods of preparing the mycotoxin-deactivating aptamer-based composition and also the methods of using it as a feed additive. Furthermore, the invention relates to the use of the mycotoxin-deactivator/s alone, or in a composition comprising the aptamers and other mycotoxin-detoxifying agents, in feeds and feed ingredients for detoxifying the major mycotoxins such as aflatoxins, deoxynivalenol, zearalenone, fumonisins and ochratoxin A.Type: GrantFiled: September 14, 2016Date of Patent: May 16, 2023Assignee: Mycotox Solutions Inc.Inventors: Ronald R. Marquardt, Srinivasa Madhyastha
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Publication number: 20220054383Abstract: Compositions comprising one or more chelating agents and optionally zinc ion salts are used to inhibit the growth or biofilm formation in bacteria associated with personal care products such as ophthalmic, pedicure, manicure or podiatric solutions. The compositions of the present application can also comprise gelling agents, antimicrobials, antibiotic or a pH adjuster. The compositions may be in the form of a solution, a gel, a cream, a jelly, a powder, a paste, a lotion, soap and a cleaner.Type: ApplicationFiled: August 3, 2021Publication date: February 24, 2022Inventors: Purushottam V. GAWANDE, Karen LOVETRI, Nandadeva YAKANDAWALA, Gord FROEHLICH, Srinivasa MADHYASTHA
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Publication number: 20210346470Abstract: Methods for the prevention and treatment of oral cavity diseases caused by dental plaque/biofilm, such as dental caries, gingivitis and periodontitis, through anti-infective properties are disclosed. The methods use a combination of EDTA and citrate. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive oral bacteria occurring in polymicrobial dental biofilms. The composition may be in the form of wash, rinse, soak, paste, gel, spray, or other suitable form.Type: ApplicationFiled: July 21, 2021Publication date: November 11, 2021Inventors: Karen LOVETRI, Srinivasa MADHYASTHA, Nandadeva YAKANDAWALA, Purushottam V. GAWANDE, Gord FROEHLICH
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Patent number: 11103433Abstract: Compositions comprising one or more chelating agents and optionally zinc ion salts are used to inhibit the growth or biofilm formation in bacteria associated with personal care products such as ophthalmic, pedicure, manicure or podiatric solutions. The compositions of the present application can also comprise gelling agents, antimicrobials, antibiotic or a pH adjuster. The compositions may be in the form of a solution, a gel, a cream, a jelly, a powder, a paste, a lotion, soap and a cleaner.Type: GrantFiled: June 26, 2015Date of Patent: August 31, 2021Assignee: KANE BIOTECH INC.Inventors: Purushottam V. Gawande, Karen Lovetri, Nandadeva Yakandawala, Gord Froehlich, Srinivasa Madhyastha
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Patent number: 11090366Abstract: Compositions comprising iron-sequestering glycoproteins, chelating agents, stabilizing agents, binding agents, surfactants, fluorides, antimicrobials and a pH adjuster or buffer for the prevention and treatment of oral cavity diseases caused by dental plaque/biofilm, such as dental caries, gingivitis and periodontitis, through anti-infective properties are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive oral bacteria occurring in polymicrobial dental biofilms. The composition may be in the form of wash, rinse, soak, paste, gel, spray, or other suitable form. Additionally, the invention offers an efficient method of delivering the formulated composition containing a PEGylated or fluorinated iron-sequestering glycoprotein and one or two chelating agents or chelating agents alone using either a liposomal or a nanoparticle delivery system.Type: GrantFiled: June 27, 2012Date of Patent: August 17, 2021Assignee: Kane Biotech Inc.Inventors: Karen LoVetri, Srinivasa Madhyastha, Nandadeva Yakandawala, Purushottam V. Gawande, Gord Froehlich
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Patent number: 10357470Abstract: Compositions comprising chelating agents, metal ion salts, gelling agents or a buffer, antimicrobials, antibiofilm agents and a pH adjuster or a buffer for the prevention and treatment of wound infections and food-borne diseases involving bacterial biofilms are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive wound infection associated bacteria occurring in polymicrobial biofilms. The composition may be in the form of lotion, cream, ointment, dressing, bandage, rinse, soak, gel, spray, or other suitable forms, including certain devices. Additionally, the invention offers an efficient method of delivering the formulated composition containing one or two chelating agents or chelating agents alone or in combination with a metal ion salt using either a nanoparticle or other efficient delivery systems.Type: GrantFiled: July 18, 2017Date of Patent: July 23, 2019Assignee: KANE BIOTECH INC.Inventors: Purushottam V. Gawande, Karen Lovetri, Nandadeva Yakandawala, Gordon Froehlich, Srinivasa Madhyastha
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Publication number: 20190076345Abstract: Compositions comprising one or more chelating agents and optionally zinc ion salts are used to inhibit the growth or biofilm formation in bacteria associated with personal care products such as ophthalmic, pedicure, manicure or podiatric solutions. The compositions of the present application can also comprise gelling agents, antimicrobials, antibiotic or a pH adjuster. The compositions may be in the form of a solution, a gel, a cream, a jelly, a powder, a paste, a lotion, soap and a cleaner.Type: ApplicationFiled: June 26, 2015Publication date: March 14, 2019Inventors: Purushottam V. Gawande, Karen Lovetri, Nandadeva Yakandawala, Gord Froehlich, Srinivasa Madhyastha
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Publication number: 20180325936Abstract: Mycotoxin-deactivating aptamers, especially DNA aptamers, bind to mycotoxins in feed and feed ingredients resulting in the reduction or elimination of toxic and carcinogenic effects of mycotoxins. The invention also discloses a composition comprising a mycotoxin-deactivating aptamer, a binding agent, a biotransforming agent and an antioxidant for detoxifying mycotoxins in feeds. In addition, the invention teaches the methods of preparing said mycotoxin-deactivating aptamer-based composition and also the methods of using it as a feed additive. Furthermore, the invention relates to the use of said mycotoxin-deactivator/s alone, or in a composition comprising said aptamers and other mycotoxin-detoxifying agents, in feeds and feed ingredients for detoxifying the major mycotoxins such as aflatoxins, deoxynivalenol, zearalenone, fumonisins and ochratoxin A.Type: ApplicationFiled: September 14, 2016Publication date: November 15, 2018Inventors: Ronald R. MARQUARDT, Srinivasa MADHYASTHA
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Patent number: 9980497Abstract: Compositions comprising chelating agents, metal ion salts, gelling agents or a buffer, antimicrobials, antibiofilm agents and a pH adjuster or a buffer for the prevention and treatment of wound infections and food-borne diseases involving bacterial biofilms are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive wound infection associated bacteria occurring in polymicrobial biofilms. The composition may be in the form of lotion, cream, ointment, dressing, bandage, rinse, soak, gel, spray, or other suitable forms, including certain devices. Additionally, the invention offers an efficient method of delivering the formulated composition containing one or two chelating agents or chelating agents alone or in combination with a metal ion salt using either a nanoparticle or other efficient delivery systems.Type: GrantFiled: March 6, 2014Date of Patent: May 29, 2018Assignee: KANE BIOTECH, INC.Inventors: Purushottam V. Gawande, Karen Lovetri, Nandadeva Yakandawala, Gordon Froelich, Srinivasa Madhyastha
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Patent number: 9936712Abstract: Compositions comprising chelating agents, metal ion salts, gelling agents or a buffer, antimicrobials, antibiofilm agents and a pH adjuster or a buffer for the prevention and treatment of wound infections and food-borne diseases involving bacterial biofilms are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive wound infection associated bacteria occurring in polymicrobial biofilms. The composition may be in the form of lotion, cream, ointment, dressing, bandage, rinse, soak, gel, spray, or other suitable forms, including certain devices. Additionally, the invention offers an efficient method of delivering the formulated composition containing one or two chelating agents or chelating agents alone or in combination with a metal ion salt using either a nanoparticle or other efficient delivery systems.Type: GrantFiled: March 6, 2014Date of Patent: April 10, 2018Assignee: KANE BIOTECH, INC.Inventors: Purushottam V. Gawande, Karen Lovetri, Nandadeva Yakandawala, Gordon Froelich, Srinivasa Madhyastha
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Publication number: 20180015061Abstract: Compositions comprising chelating agents, metal ion salts, gelling agents or a buffer, antimicrobials, antibiofilm agents and a pH adjuster or a buffer for the prevention and treatment of wound infections and food-borne diseases involving bacterial biofilms are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive wound infection associated bacteria occurring in polymicrobial biofilms. The composition may be in the form of lotion, cream, ointment, dressing, bandage, rinse, soak, gel, spray, or other suitable forms, including certain devices. Additionally, the invention offers an efficient method of delivering the formulated composition containing one or two chelating agents or chelating agents alone or in combination with a metal ion salt using either a nanoparticle or other efficient delivery systems.Type: ApplicationFiled: July 18, 2017Publication date: January 18, 2018Inventors: Purushottam V. Gawande, Karen Lovetri, Nandadeva Yakandawala, Gordon Froehlich, Srinivasa Madhyastha
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Publication number: 20170128338Abstract: Compositions comprising one or more chelating agents and optionally zinc ion salts are used to inhibit the growth or biofilm formation in bacteria associated with personal care products such as ophthalmic, pedicure, manicure or podiatric solutions. The compositions of the present application can also comprise gelling agents, antimicrobials, antibiotic or a pH adjuster. The compositions may be in the form of a solution, a gel, a cream, a jelly, a powder, a paste, a lotion, soap and a cleaner.Type: ApplicationFiled: June 26, 2015Publication date: May 11, 2017Inventors: Purushottam V. Gawande, Karen Lovetri, Nandadeva Yakandawala, Gord Froehlich, Srinivasa Madhyastha
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Patent number: 9622481Abstract: The present invention provides novel compositions comprising: (a) a metaperiodate and (b) chlorhexidine or a chlorohexidine salt and uses thereof for the preparation of devices, and in particular medical devices, susceptible to colonization by biofilm forming bacteria.Type: GrantFiled: May 1, 2014Date of Patent: April 18, 2017Assignee: Kane Biotech Inc.Inventors: Purushottam Gawande, Srinivasa Madhyastha, Karen Lovetri, Nandadeva Yakandawala, Gord Froehlich
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Publication number: 20160015047Abstract: Compositions comprising chelating agents, metal ion salts, gelling agents or a buffer, antimicrobials, antibiofilm agents and a pH adjuster or a buffer for the prevention and treatment of wound infections and food-borne diseases involving bacterial biofilms are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive wound infection associated bacteria occurring in polymicrobial biofilms. The composition may be in the form of lotion, cream, ointment, dressing, bandage, rinse, soak, gel, spray, or other suitable forms, including certain devices. Additionally, the invention offers an efficient method of delivering the formulated composition containing one or two chelating agents or chelating agents alone or in combination with a metal ion salt using either a nanoparticle or other efficient delivery systems.Type: ApplicationFiled: March 6, 2014Publication date: January 21, 2016Inventors: Purushottam V. GAWANDE, Karen Lovetri, Nandadeva Yakandawala, Gord Froelich, Srinivasa Madhyastha
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Publication number: 20150087582Abstract: Compositions comprising iron-sequestering glycoproteins, chelating agents, stabilizing agents, binding agents, surfactants, fluorides, antimicrobials and a pH adjuster or buffer for the prevention and treatment of oral cavity diseases caused by dental plaque/biofilm, such as dental caries, gingivitis and periodontitis, through anti-infective properties are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive oral bacteria occurring in polymicrobial dental biofilms. The composition may be in the form of wash, rinse, soak, paste, gel, spray, or other suitable form. Additionally, the invention offers an efficient method of delivering the formulated composition containing a PEGylated or fluorinated iron-sequestering glycoprotein and one or two chelating agents or chelating agents alone using either a liposomal or a nanoparticle delivery system.Type: ApplicationFiled: June 27, 2012Publication date: March 26, 2015Inventors: Karen LoVetri, Srinivasa Madhyastha, Nandadeva Yakandawala, Purushottam V. Gawande, Gord Froehlich
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Patent number: 8906364Abstract: The present invention provides compositions for preventing growth and proliferation of biofilm embedded microorganisms on devices comprising: (a) a cationic polypeptide and (b) a bis-guanide or a salt thereof. The invention further provides methods for preparing medical devices with such compositions.Type: GrantFiled: January 11, 2006Date of Patent: December 9, 2014Assignee: Kane Biotech Inc.Inventor: Srinivasa Madhyastha
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Publication number: 20140322351Abstract: The present invention provides novel compositions comprising: (a) a metaperiodate and (b) chlorhexidine or a chlorohexidine salt and uses thereof for the preparation of devices, and in particular medical devices, susceptible to colonization by biofilm forming bacteria.Type: ApplicationFiled: May 1, 2014Publication date: October 30, 2014Applicant: Kane Biotech Inc.Inventors: Purushottam GAWANDE, Srinivasa MADHYASTHA, Karen LOVETRI, Nandadeva YAKANDAWALA, Gord FROEHLICH
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Patent number: 8821862Abstract: The present invention provides compositions comprising an antibiofilm enzyme, a soluble ?-N-acetylglucosaminidase similar to the dspB gene (DispersinBĀ®), and an antimicrobial for preventing growth and proliferation of biofilm-embedded microorganisms in acute and chronic wounds, and methods of treatment. The invention further provides methods for preparing medical devices, and in particular, wound care devices using soluble ?-N-acetylglucosaminidase based antimicrobial compositions.Type: GrantFiled: March 9, 2012Date of Patent: September 2, 2014Assignees: Kane Biotech Inc., University of Medicine and Dentistry of New JerseyInventors: Srinivasa Madhyastha, Nanda Yakandawala, Purushottam V. Gawande, Karen Lovetri, Jeffrey B. Kaplan, Daniel Rhoads, Lasha Gogokhia
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Patent number: 8753692Abstract: The present invention provides novel compositions comprising: (a) protamine sulfate and (b) benzalkonium chloride or a silver containing particle; or (a) sodium metaperiodate and (b) 5-fluorouracil or chlorhexidine and uses thereof for the preparation of devices, and in particular medical devices, susceptible to colonization by biofilm forming bacteria.Type: GrantFiled: January 22, 2010Date of Patent: June 17, 2014Assignee: Kane Biotech Inc.Inventors: Purushottam V. Gawande, Srinivasa Madhyastha, Karen Lovetri, Nandadeva Yakandawala, Gord Froehlich