Patents by Inventor Srinivasan Rengaraju

Srinivasan Rengaraju has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of azithromycin monohydrate
    Patent number: 6855813
    Abstract: The invention relates to a process for making Azithromycin crystals using a number of process steps that avoids the use of cumbersome and/or inefficient extraction and/or isolation procedures.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: February 15, 2005
    Assignee: Alembic Limited
    Inventor: Srinivasan Rengaraju
  • Intermediate and processes for its preparation and conversion into a pharmacologically-active agent
    Patent number: 6756502
    Abstract: Processes for the preparation of Venlafaxine (IX) via the novel epoxy-nitrile intermediate (I), which when subjected to hydrogenation forms compound (X), and may subsequently be reduced to yield the desired product (IX). The epoxy-nitrile intermediate (I) itself may be synthesized via various alternative reaction strategies, from a range of starting materials. E.g. 4-methoxy-benzaldehyde (VI), upon treatment with cyclohexyl magnesium bromide yields compound (V). This in turn may be oxidized to yield compound (III), which forms compound (II) on treatment with an (x-keto-halogenation agent. Cyanation of compound (II), then yields the desired epoxy nitrile intermediate (I), from which Venlafaxine (IX) may be synthesized.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: June 29, 2004
    Assignee: Alembic Limited
    Inventors: Dhiraj Mohansinh Rathod, Srinivasan Rengaraju, Milind Moreshwar Gharpure, Nishant Mahendra Patel, Mandar Manohar Deoahar
  • Process for the preparaton of azithromycin monohydrate
    Publication number: 20040014952
    Abstract: The invention relates to a process for making Azithromycin crystals using a number of process steps that avoids the use of cumbersome and/or inefficient extraction and/or isolation procedures.
    Type: Application
    Filed: July 19, 2002
    Publication date: January 22, 2004
    Applicant: Alembic Limited
    Inventor: Srinivasan Rengaraju
  • Novel intermediate and processes for its preparation and conversion into a pharmacologically-active agent
    Publication number: 20030195376
    Abstract: Processes for the preparation of Venlafaxine (IX) via the novel epoxy-nitrile intermediate (I), which when subjected to hydrogenation forms compound (X), and may subsequently be reduced to yield the desired product (IX). The epoxy-nitrile intermediate (I) itself may be synthesised via various alternative reaction strategies, from a range of starting materials. E.g. 4-methoxy-benzaldehyde (VI), upon treatment with cyclohexyl magnesium bromide yields compound (V). This in turn may be oxidised to yield compound (III), which forms compound (II) on treatment with an (x-keto-halogenation agent. Cyanation of compound (II), then yields the desired epoxy nitrile intermediate (I), from which Venlafaxine (IX) may be synthesised.
    Type: Application
    Filed: April 10, 2002
    Publication date: October 16, 2003
    Inventors: Dhiraj Mohansinh Rathod, Srinivasan Rengaraju, Milind Moreshwar Gharpure, Nishant Mahendra Patel, Mandar Manohar Deoahar
  • Process for the preparation of non-hygroscopic azithromycin dihydrate
    Publication number: 20020111318
    Abstract: An improved process for preparing non-hygroscopic Azithromycin dihydrate wherein Azithromycin monhydrate can be converted to Azithromycin dihydrate with continous stirring/agitation in presence of a mixture of at least one solvent and water until non-hygroscopic crystals of Azithromycin dihydrate are obtained. The solvent used in the process can be selected from the group comprising dimethylformamide, dimethylacetamide, acetonitrile and iso-propanol.
    Type: Application
    Filed: January 18, 2002
    Publication date: August 15, 2002
    Inventor: Srinivasan Rengaraju