Patents by Inventor Srinivasulu VUNNAM

Srinivasulu VUNNAM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12157745
    Abstract: A compound represented by following formula I: according to the present disclosure. The disclosed compound is useful in the treatment of many disease states related to cell proliferation. In particular, new pyran derivatives are provided along with processes for preparations and methods for pharmaceutical applications, for example, as anticancer agents. The compound was found to have antiproliferative effects against multiple cancer cell lines and showed low toxicity to normal fibroblasts. The disclosed compound also exhibited anticancer properties by inducing caspase-mediated cell death mechanisms and arresting cancer cell progression. Further, the compound represented by Formula I targets multiple key proteins/enzymes, including thioredoxin reductase, glutathione reductase, transferrin receptors, inisitol-3-phosphate synthase, cystolic aminopeptidase, and transketolase, which are over-expressed in tumor cells.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: December 3, 2024
    Assignee: UNIVERSITY OF SHARJAH
    Inventors: Taleb H. Altel, Raafat A El-Awady, Srinivasulu Vunnam, Cijo George Vazhappilly, Hany A. Omar
  • Publication number: 20240002402
    Abstract: The present invention relates to the prevention, prophylactic and therapeutic treatment of autoimmune diseases including but not limited to multiple sclerosis by administering novel small molecules to a subject in need thereof.
    Type: Application
    Filed: September 8, 2023
    Publication date: January 4, 2024
    Inventors: Azzam A. Maghazachi, Taleb Al-Tel, Sarah Dhaiban, Mena Al-Ain, Noha Mousaad Elemam, Srinivasulu Vunnam
  • Publication number: 20220185823
    Abstract: The present invention relates to the prevention, prophylactic and therapeutic treatment of autoimmune diseases including but not limited to multiple sclerosis by administering novel small molecules to a subject in need thereof.
    Type: Application
    Filed: December 15, 2020
    Publication date: June 16, 2022
    Inventors: Azzam A. Maghazachi, Taleb Al-Tel, Sarah Dhaiban, Mena Al-Ain, Noha Mousaad Elemam, Srinivasulu Vunnam
  • Publication number: 20210221825
    Abstract: Novel heterocyclic systems are herein disclosed, which possess many biological activities, including but not limited to anticancer activity. The disclosed compounds are useful in the treatment of many disease states related to cell proliferation. In particular, new pyran derivatives are provided along with processes for their preparations and methods for their pharmaceutical applications, for example, as anticancer agents. These compounds were found to have antiproliferative effects against multiple cancer cell lines and showed low toxicity to normal fibroblasts. The disclosed compounds also exhibited anticancer properties by inducing caspase-mediated cell death mechanisms and arresting cancer cell progression. Further, these novel compounds were able to target multiple key proteins/enzymes, including thioredoxin reductase, glutathione reductase, transferrin receptors, inisitol-3-phosphate synthase, cystolic aminopeptidase, and transketolase, which are over-expressed in tumor cells.
    Type: Application
    Filed: December 4, 2020
    Publication date: July 22, 2021
    Inventors: Taleb H. Altel, Raafat A El-Awady, Srinivasulu Vunnam, Cijo George Vazhappilly, Hany A. Omar
  • Patent number: 10526343
    Abstract: Novel heterocyclic fused systems are disclosed herein which possess numerous biological activities, including but not limited to antibacterial activity, and usefulness to the treatment of many disease states, such as pathogenic infections. In particular, new imidazoles are disclosed along with related processes of preparation and methods of use as antibacterial agents. The disclosed compounds were found to be active against several Gram-positive bacteria, including Enterococcus faecalis and Bacillus subtilis, and were also found to be active against several species of multi-drug resistant Staphylococcus, such as S. aureus, S. saprophyticus, S. haemolyticus, and S. epidermidis.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: January 7, 2020
    Assignee: UNIVERSITY OF SHARJAH
    Inventors: Taleb H. Altel, Raafat A El-Awady, Srinivasulu Vunnam, Farah Ibrahim Al-Marzooq
  • Publication number: 20190292204
    Abstract: Novel heterocyclic systems are herein disclosed, which possess many biological activities, including but not limited to anticancer activity. The disclosed compounds are useful in the treatment of many disease states related to cell proliferation. In particular, new pyran derivatives are provided along with processes for their preparations and methods for their pharmaceutical applications, for example, as anticancer agents. These compounds were found to have antiproliferative effects against multiple cancer cell lines and showed low toxicity to normal fibroblasts. The disclosed compounds also exhibited anticancer properties by inducing caspase-mediated cell death mechanisms and arresting cancer cell progression. Further, these novel compounds were able to target multiple key proteins/enzymes, including thioredoxin reductase, glutathione reductase, transferrin receptors, inisitol-3-phosphate synthase, cystolic aminopeptidase, and transketolase, which are over-expressed in tumor cells.
    Type: Application
    Filed: March 26, 2018
    Publication date: September 26, 2019
    Inventors: Taleb H. Altel, Raafat A El-Awady, Srinivasulu Vunnam, Cijo George Vazhappilly, Hany A. Omar
  • Publication number: 20190292202
    Abstract: Novel heterocyclic fused systems are disclosed herein which possess numerous biological activities, including but not limited to antibacterial activity, and usefulness to the treatment of many disease states, such as pathogenic infections. In particular, new imidazoles are disclosed along with related processes of preparation and methods of use as antibacterial agents. The disclosed compounds were found to be active against several Gram-positive bacteria, including Enterococcus faecalis and Bacillus subtilis, and were also found to be active against several species of multi-drug resistant Staphylococcus, such as S. aureus, S. saprophyticus, S. haemolyticus, and S. epidermidis.
    Type: Application
    Filed: March 26, 2018
    Publication date: September 26, 2019
    Inventors: Taleb H. Altel, Raafat A El-Awady, Srinivasulu Vunnam, Farah Ibrahim Al-Marzooq
  • Patent number: 9522907
    Abstract: The present invention provides a compound of general formula A for use as a potential anticancer agent against human cancer cell lines and a process for the preparation thereof wherein R is selected from the group consisting of H, F, Cl, Br, OMe, Me and CF3, R1 is selected from the group consisting of H, 4-F, 4-Cl, 4-Br, 4-CF3, 4-OMe, 3,4-OMe, 3,5-OMe and 3,4,5-OMe, and n is an integer ranging from 1-3.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: December 20, 2016
    Assignee: Council of Scientific & Industrial Research
    Inventors: Kamal Ahmed, Srinivasa Reddy Telukutla, Srinivasulu Vunnam, Venkata Subbarao Ayinampudi, Shankaraiah Nagula, Venkata Phani Surya Vishnu Vardhan Madugulla
  • Publication number: 20160002214
    Abstract: The present invention provides a compound of general formula A for use as a potential anticancer agent against human cancer cell lines and a process for the preparation thereof. wherein R is selected from the group consisting of H, F, Cl, Br, OMe, Me and CF3, R1 is selected from the group consisting of H, 4-F, 4-Cl, 4-Br, 4-CF3, 4-OMe, 3,4-OMe, 3,5-OMe and 3,4,5-OMe, and n is an integer ranging from 1-3.
    Type: Application
    Filed: July 7, 2015
    Publication date: January 7, 2016
    Inventors: Kamal AHMED, Srinivasa Reddy TELUKUTLA, Srinivasulu VUNNAM, Venkata Subbarao AYINAMPUDI, Shankaraiah NAGULA, Venkata Phani Surya Vishnu Vardhan MADUGULLA