Patents by Inventor Sriram Subramaniam

Sriram Subramaniam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Probe and method for obtaining three-dimensional compositional maps of a biological sample
    Patent number: 8941057
    Abstract: The invention provides a probe and a method of obtaining a three-dimensional compositional map of one or more targets in a biological sample, or a portion thereof, comprising: (a) milling a surface layer of a biological sample with a focused ion beam, thereby creating a newly exposed surface layer of the biological sample; (b) imaging the newly exposed surface layer of the biological sample; (c) identifying the chemical composition of the newly exposed surface layer of the biological sample, or a portion thereof, with a mass spectrometer; and (d) repeating (a) to (c) until a three-dimensional compositional map of one or more targets in the biological sample, or portion thereof, is obtained. Uses of the three-dimensional map obtained from the inventive method are further provided.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: January 27, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventor: Sriram Subramaniam
  • PROBE AND METHOD FOR OBTAINING THREE-DIMENSIONAL COMPOSITIONAL MAPS OF A BIOLOGICAL SAMPLE
    Publication number: 20110011190
    Abstract: The invention provides a probe and a method of obtaining a three-dimensional compositional map of one or more targets in a biological sample, or a portion thereof, comprising: (a) milling a surface layer of a biological sample with a focused ion beam, thereby creating a newly exposed surface layer of the biological sample; (b) imaging the newly exposed surface layer of the biological sample; (c) identifying the chemical composition of the newly exposed surface layer of the biological sample, or a portion thereof, with a mass spectrometer; and (d) repeating (a) to (c) until a three-dimensional compositional map of one or more targets in the biological sample, or portion thereof, is obtained. Uses of the three-dimensional map obtained from the inventive method are further provided.
    Type: Application
    Filed: September 4, 2008
    Publication date: January 20, 2011
    Inventor: Sriram Subramaniam
  • Packages that Contain Pre-Paginated Documents
    Publication number: 20080168342
    Abstract: Modular content framework and document format methods and systems are described. The described framework and format define a set of building blocks for composing, packaging, distributing, and rendering document-centered content. These building blocks define a platform-independent framework for document formats that enable software and hardware systems to generate, exchange, and display documents reliably and consistently. The framework and format have been designed in a flexible and extensible fashion. In addition to this general framework and format, a particular format, known as the reach package format, is defined using the general framework. The reach package format is a format for storing paginated documents. The contents of a reach package can be displayed or printed with full fidelity among devices and applications in a wide range of environments and across a wide range of scenarios.
    Type: Application
    Filed: March 21, 2008
    Publication date: July 10, 2008
    Applicant: Microsoft Corporation
    Inventors: Andrey Shur, Daniel F. Emerson, David Ornstein, Joe King, Oliver H. Foehr, Wei Zhu, Jerry Dunietz, Sriram Subramaniam
  • Structure determination of materials using electron microscopy
    Patent number: 6987266
    Abstract: The invention includes methods for automating acquisition of electron microscopic images.
    Type: Grant
    Filed: April 22, 2002
    Date of Patent: January 17, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Sriram Subramaniam
  • Structure determination of materials using electron microscopy
    Publication number: 20050056784
    Abstract: The invention includes methods for automating acquisition of electron microscopic images.
    Type: Application
    Filed: April 22, 2002
    Publication date: March 17, 2005
    Inventor: Sriram Subramaniam