Patents by Inventor Stéphane Frein

Stéphane Frein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the in situ preparation of chiral compounds derived from oxazaborolidine-borane complexes which are used in asymmetric reduction reactions
    Patent number: 7365212
    Abstract: A process for the in situ preparation of chiral compounds derived from oxazaborolidine-borane complexes, wherein a metal borohydride, a Lewis base and an inorganic acid ester are brought together and an optically active amino alcohol and optionally a halide are then added. The compound obtained is a complex that is useful as a catalyst in asymmetric reduction reactions. The reaction is performed by adding the substance to be reduced, particularly prochiral ketones or ether oximes, in order to synthesize chiral alcohols or chiral amines.
    Type: Grant
    Filed: October 11, 2004
    Date of Patent: April 29, 2008
    Assignee: ZaCh System S.p.A.
    Inventors: Alain Burgos, Blandine Bertrand, Stéphane Frein, Jean-François Pluvie, Sonia Roussiasse