Abstract: The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing the compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.

Abstract: The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing said compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.

Abstract: The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing said compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.

Abstract: A bundle includes wire segments forming a branch fitted with an angled coupling including: a base having the ends of the wire segments fastened thereto; an angled rigid casing surrounding the wire segments and having a first end providing for bearing against the base; and a member for fastening the casing to the base with a mutual variable orientation; the branch is protected by a shielding sheath secured to a second end of the casing; the bundle includes an abutment member secured to the portion of the wire segments extending inside the angled casing and co-operating with the angled casing to prevent the portion of the wire segments from leaving the casing; the portion of the wire segments is twisted in such a manner that the mutual orientation between the base and the casing can be modified without introducing harmful mechanical stresses in these wire segment portions.

Abstract: An electrical equipment containment is arranged on a cooling enclosure opening out onto the outside. An outlet orifice makes the containment communicate with the cooling enclosure. This orifice is closed by a membrane or a check valve. A grate separates the cooling enclosure into an upper volume and a lower volume. The grate supports a layer of solid granular material the upper surface whereof remains free. This material is preferably porous and also comprises dusts. In the event of an internal electric arc, the shock wave escaping from the containment is dampened by the surface deformation of the layer of solid material. The incandescent particles projected via the opening are stopped by the layer of solid material. The hot gases are cooled as they flow through the material, causing a cloud of dust contributing to preventing any post-combustion.

Abstract: A bundle includes wire segments forming a branch fitted with an angled coupling including: a base having the ends of the wire segments fastened thereto; an angled rigid casing surrounding the wire segments and having a first end providing for bearing against the base; and a member for fastening the casing to the base with a mutual variable orientation; the branch is protected by a shielding sheath secured to a second end of the casing; the bundle includes an abutment member secured to the portion of the wire segments extending inside the angled casing and co-operating with the angled casing to prevent the portion of the wire segments from leaving the casing; the portion of the wire segments is twisted in such a manner that the mutual orientation between the base and the casing can be modified without introducing harmful mechanical stresses in these wire segment portions.

Abstract: An electrical equipment containment is arranged on a cooling enclosure opening out onto the outside. An outlet orifice makes the containment communicate with the cooling enclosure. This orifice is closed by a membrane or a check valve. A grate separates the cooling enclosure into an upper volume and a lower volume. The grate supports a layer of solid granular material the upper surface whereof remains free. This material is preferably porous and also comprises dusts. In the event of an internal electric arc, the shock wave escaping from the containment is dampened by the surface deformation of the layer of solid material. The incandescent particles projected via the opening are stopped by the layer of solid material. The hot gases are cooled as they flow through the material, causing a cloud of dust contributing to preventing any post-combustion.