Abstract: A method for selective labelling of necrotic cells including incubating the cells in a solution including a Ln(III)Zn16(HA ligand)16 metallacrown complex, wherein the HA ligand is a hydroximate ligand.

Abstract: Dendrimeric metallacrowns may include a monomeric metallacrown complex or a dimeric metallacrown complex. In an example, the dendrimeric metallacrown includes the monomeric metallacrown complex and a dendron. In this example, the monomeric metallacrown complex includes a central ion, and a metallomacrocycle attached to the central ion. The central ion is selected from the group consisting of a lanthanide ion, a d-block transition metal ion or rare earth metal ion, and an s-block alkali or alkaline earth metal. The metallomacrocycle includes a repeating sub-unit consisting of a metal ion and a ring ligand selected from the group consisting of a hydroxamic acid derivative and an oxime derivative. The dendron is respectively attached to each of the ring ligands of the metallomacrocycle.

Abstract: The present invention relates to a complex comprising at least one lanthanide (Ln) and at least one compound (C) comprising a unit of formula (I) below: said unit of formula (I) being covalently connected to at least one antenna which absorbs at a wavelength ranging from 500 nm to 900 nm.

Abstract: A method for selective labelling of necrotic cells including incubating the cells in a solution including a Ln(III)Zn16(HA ligand)16 metallacrown complex, wherein the HA ligand is a hydroximate ligand.

Abstract: The present invention relates to a complex comprising at least one dendrimer and at least one lanthanide, wherein the dendrimer comprises a unit of formula (I) below: in which: C1 is a valence group 4 of formula >N—CH2—CH2—N<; A1, A2 and A3 are groups of formula —(CH2)2—C(O)—NH—(CH2)2—; the unit of formula (I) being connected covalently to at least one antenna which absorbs at a wavelength ranging from 500 nm to 900 nm.

Abstract: Dendrimeric metallacrowns may include a monomeric metallacrown complex or a dimeric metallacrown complex. In an example, the dendrimeric metallacrown includes the monomeric metallacrown complex and a dendron. In this example, the monomeric metallacrown complex includes a central ion, and a metallomacrocycle attached to the central ion. The central ion is selected from the group consisting of a lanthanide ion, a d-block transition metal ion or rare earth metal ion, and an s-block alkali or alkaline earth metal. The metallomacrocycle includes a repeating sub-unit consisting of a metal ion and a ring ligand selected from the group consisting of a hydroxamic acid derivative and an oxime derivative. The dendron is respectively attached to each of the ring ligands of the metallomacrocycle.

Abstract: The present invention relates to a complex comprising at least one lanthanide (Ln) and at least one compound (C) comprising a unit of formula (I) below: said unit of formula (I) being covalently connected to at least one antenna which absorbs at a wavelength ranging from 500 nm to 900 nm.

Abstract: In an example of a method for simultaneously fixing and staining cells, the cells are initially incubated in a solution including a Ln(III)Zn16(HA ligand)16 metallacrown complex, wherein the HA ligand is a hydroximate ligand. The incubating cells are exposed to ultraviolet (UV) light. The cells are allowed to continue to incubate in the solution after UV light exposure.

Abstract: In an example of a method for simultaneously fixing and staining cells, the cells are initially incubated in a solution including a Ln(III)Zn16(HA ligand)16 metallacrown complex, wherein the HA ligand is a hydroximate ligand. The incubating cells are exposed to ultraviolet (UV) light. The cells are allowed to continue to incubate in the solution after UV light exposure.

Abstract: A metallacrown complex has the formula: Ln(III)[12-MC-4]2[24-MC-8], wherein MC is a metallacrown macrocycle with a repeating sub-unit consisting of a transition metal (M(II)) and a hydroxamic acid (HA) ligand that produces a ligand-based charge transfer state when incorporated into the metallacrown complex. In an example of a method for making the metallacrown complex, a hydroxamic acid (HA) ligand that is to produce a ligand-based charge transfer state when incorporated into the metallacrown complex, a transition metal salt, and a rare-earth salt are dissolved in a solvent to form a solution. A base is added to the solution. The solution is stirred at a predetermined temperature for a predetermined time. The solution is exposed to a purification method to produce crystals of the metallacrown complex.

Abstract: In an example of a method for simultaneously fixing and staining cells, the cells are initially incubated in a solution including a Ln(III)Zn16(HA ligand)16 metallacrown complex, wherein the HA ligand is a hydroximate ligand. The incubating cells are exposed to ultraviolet (UV) light. The cells are allowed to continue to incubate in the solution after UV light exposure.

Abstract: A metallacrown complex has the formula: Ln(III)[12-MC-4]2[24-MC-8], wherein MC is a metallacrown macrocycle with a repeating sub-unit consisting of a transition metal (M(II)) and a hydroxamic acid (HA) ligand that produces a ligand-based charge transfer state when incorporated into the metallacrown complex. In an example of a method for making the metallacrown complex, a hydroxamic acid (HA) ligand that is to produce a ligand-based charge transfer state when incorporated into the metallacrown complex, a transition metal salt, and a rare-earth salt are dissolved in a solvent to form a solution. A base is added to the solution. The solution is stirred at a predetermined temperature for a predetermined time. The solution is exposed to a purification method to produce crystals of the metallacrown complex.

Abstract: The present invention relates to particles, useful for drug release detection, comprising: at least one luminescent metal complex of formula [Ln].[L], wherein: Ln is a lanthanide ion, L is an organic ligand comprising a hydrophilic unit with at least 6 chelating groups chosen from the group consisting of hydroxyl, carboxyl, optionally in the carboxylate form, carbonyl, ether, phosphonate, phosphinate, thiolate, amino and imino functions, and at least one drug comprising a conjugated aromatic system, wherein said drug is not covalently bonded to the metal complex, said particle having a size comprised from 3 nm to 2000 nm, and wherein the distribution of the metal complex and the drug within the particle is such that the mean distance between a drug molecule and a metal complex is less than 15 nm.

Abstract: Metal-organic frameworks (MOFs) are crystalline porous materials that include metal ions linked together into periodic structures via organic ligands. MOFs that contain lanthanide ions are a new class of visible and near-IR luminescent materials, suitable for a broad range of applications. For example, the MOF framework afforded by 2,5-dimethoxy-1,4-phenylene)di-2,1-ethenediyl]bis-carboxylate is associated with unusually long luminescence lifetimes. Thus, a complex of this ligand with a lanthanide provides a sharp emission profile, coupled with a comparatively long signal lifetime, for an unusually high luminescence. More generally, lanthanide-MOF systems exhibit several advantages that are ideal for barcoded materials, due to the photophysical attributes of lanthanide cations and the well-defined organization of the MOF structure.

Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.

Abstract: A method of detecting an analyte in an environment, includes immobilizing at least one photoactive composition on nanostructures, the photoactive composition exhibiting emission that is sensitive to the analyte; applying electromagnetic radiation to the immobilized photoactive moiety for a period of time; measuring at least one response; and using the measured response to determine the presence the analyte in the environment. The nanostructures can, for example, include carbon nanostructures. In a number of embodiments, the analyte is oxygen.

Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.

Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.

Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.

Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.