Patents by Inventor Stéphane Roux
Stéphane Roux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20260097075Abstract: A method to control or change the polarization of at least one macrophage associated with a tumor or pathological site (TAM), from being predominantly a TAM with either no polarization (M0) or a polarization i (Mi) before at least one step of the method, to a predominant polarization j (Mj), by associating at least one TAM with a nanoparticle, preferentially a magnetosome, 10 and by exposing the assembly to a radiation, where Mi=Mi and Mj=M2 or Mi=M2 and Mj'M1.Type: ApplicationFiled: October 3, 2025Publication date: April 9, 2026Applicants: UNIVERSITE PARIS CITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, NANOBACTERIE, UNIVERSITE DE FRANCHE-COMTEInventors: Sonia BÉCHAREF, Edouard ALPHANDÉRY, Florence GAZEAU, Stéphane ROUX, Jean-Philippe HERBEUVAL, Léa JABBOUR, Nathalie LUCIANI, Amanda SILVA
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Patent number: 12533426Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRD and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.Type: GrantFiled: October 4, 2022Date of Patent: January 27, 2026Assignees: NANOH, UNIVERSITE LYON 1 CLAUDE BERNARD, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: François Lux, Olivier Tillement, Maxime Saint Jean, Pierre Mowat, Pascal Perriat, Stéphane Roux, Anna Mignot
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Publication number: 20250308013Abstract: The invention relates to a non-destructive inspection method based on 3D modelling of a part, comprising: using an x-ray device to acquire images of the part at various projection angles; computing projections based on the images acquired at the various projection angles; in each of multiple iterations: generating simulated projections corresponding to the computed projections, based on a reference model of an external surface of the part and on a vector ? of transformation parameters of the reference model; modifying the vector ? with a view to reducing a discrepancy between the simulated projections and the computed projections; determining a corrected model of the external surface through transformation of the reference model by way of the vector ? resulting from the iterations; determining an effective model of the part by way of the corrected model.Type: ApplicationFiled: May 11, 2023Publication date: October 2, 2025Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), SAFRAN, ECOLE NORMALE SUPERIEURE PARIS-SACLAYInventors: Cédric FRAGNAUD, Clément REMACHA, Stéphane ROUX, Julian BETANCUR
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Publication number: 20240377341Abstract: The invention relates to a method for non-destructively testing a part by means of transmission radiography, which method comprises the following steps of acquiring N projections (P(n)) of the part, generating calculated N images (P(n)) of the part, estimating, by successive iterations, the vector p from an initial vector p=pini and the vector c from an initial vector c=cini and/or the parameter vector a from an initial vector ?=?ini, by minimising the sum of the squared differences between the projections (P(n)) and the images (P(n)), processing the projections (P(n)) and/or the images (P(n)), identifying defects in the part by comparing the processed projections (P(n)) and the processed images (P(n)).Type: ApplicationFiled: September 8, 2022Publication date: November 14, 2024Applicants: SAFRAN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE PARIS-SACLAYInventors: Cédric FRAGNAUD, Stéphane ROUX, Julian BETANCUR
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Publication number: 20240295476Abstract: A method for characterizing a mechanical part making it possible to evaluate the residual stresses in the part, as well as a method for constructing a predictive model and a non-destructive testing method making it possible to easily test such a part, the characterizing method including the following steps: measuring geometrical information of the part in a first state, physically transforming the part between the first state and a second state, measuring geometrical information of the part in its second state, determining the displacement field between the first state and the second state of the part by a digital image correlation method and obtaining the deformation field between the first state and the second state of the part, determining the stress field in the second state of the part by a finite element simulation method.Type: ApplicationFiled: June 16, 2022Publication date: September 5, 2024Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE PARIS- SACLAY, SAFRAN, SAFRAN AIRCRAFT ENGINESInventors: Julien Paul SCHNEIDER-DIE-GROSS, Arturo MENDOZA QUISPE, Stéphane ROUX
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Publication number: 20240054631Abstract: Method for processing a plurality of X-ray tomography volume images each associated with a part, the plurality of volume images comprising a reference volume image, including: a step of correlating volume images to obtain a displacement field between each image and the reference image, to obtain a plurality of displacement fields minimizing the difference between the volume images, a processing by a dimensionality reduction method of the plurality of the image displacement fields to express them according to eigenmodes, and a statistical analysis of the fields expressed according to the eigenmodes.Type: ApplicationFiled: December 24, 2021Publication date: February 15, 2024Applicants: SAFRAN, SAFRAN AIRCRAFT ENGINES, ECOLE NORMALE SUPERIEURE PARIS- SACLAY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Julien Paul SCHNEIDER-DIE-GROSS, Clément JAILIN, Arturo MENDOZA QUISPE, Stéphane ROUX
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Patent number: 11783473Abstract: The invention relates to a method for characterizing, from a volume image, a fibrous structure having a three-dimensional weaving between a plurality of warp yarns extending along a first direction and a plurality of weft yarns extending along a second direction perpendicular to the first one, the method comprising: a first processing of the volume image by filtering along a third direction perpendicular to the first and second directions so as to attenuate the periodic patterns along the third direction, obtaining a two-dimensional image corresponding to an intermediate plane along the third direction of the filtered volume image, a second processing of the two-dimensional image by filtering along the first or second direction so as to attenuate the periodic patterns, obtaining a one-dimensional profile representing the positions of warp or weft columns and corresponding to an intermediate line along the first or second direction.Type: GrantFiled: August 3, 2021Date of Patent: October 10, 2023Assignees: SAFRAN AIRCRAFT ENGINES, SAFRAN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQU, ECOLE NORMALE SUPERIEURE PARIS-SACLAYEInventors: Julien Paul Schneider-Die-Gross, Intisar Belhaj Saad, Arturo Mendoza Quispe, Estelle Marie Laure Parra, Stéphane Roux
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Publication number: 20230230227Abstract: The invention relates to a method for characterizing, from a volume image, a fibrous structure having a three-dimensional weaving between a plurality of warp yarns extending along a first direction and a plurality of weft yarns extending along a second direction perpendicular to the first one, the method comprising: a first processing (E10) of the volume image by filtering along a third direction perpendicular to the first and second directions so as to attenuate the periodic patterns along the third direction, obtaining (E20) a two-dimensional image corresponding to an intermediate plane along the third direction of the filtered volume image, a second processing (E31, E41) of the two-dimensional image by filtering along the first or second direction so as to attenuate the periodic patterns, obtaining (E32, E33) a one-dimensional profile representing the positions of warp or weft columns and corresponding to an intermediate line along the first or second direction of the filtered two-dimensional image, and coType: ApplicationFiled: August 3, 2021Publication date: July 20, 2023Applicants: SAFRAN AIRCRAFT ENGINES, SAFRAN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE PARIS- SACLAYInventors: Julien Paul SCHNEIDER-DIE-GROSS, Intisar BELHAJ SAAD, Arturo MENDOZA QUISPE, Estelle Marie Laure PARRA, Stéphane ROUX
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Publication number: 20230109283Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRD and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.Type: ApplicationFiled: October 4, 2022Publication date: April 6, 2023Applicants: NANOH, UNIVERSITE LYON 1 CLAUDE BERNARD, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYONInventors: François LUX, Olivier TILLEMENT, Maxime SAINT JEAN, Pierre MOWAT, Pascal PERRIAT, Stéphane ROUX, Anna MIGNOT
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Patent number: 11526980Abstract: The invention relates to a method for processing images obtained by a diffraction detector, of a crystalline or polycrystalline material, in which a first image of the material is acquired in a state of reference as well as a second image of the material in a deformed state. The invention is characterised in that, in a calculator, during a first step (E6, E12), a current elastic deformation gradient tensor Fe is given a value determined by calculation, during a second step (E7), the current displacement field induced by the tensor Fe is calculated, during a third step (E8), third digital values of a deformed image {hacek over (g)}(x)=g(x+u(x)) corrected by the current displacement field are calculated, and during an iterative algorithm, iterations of the second and third steps (E12, E7, E8) are carried out on modified values of the tensor r Fe until a convergence criterion is met in relation to the correction to the current value of Fe.Type: GrantFiled: December 7, 2018Date of Patent: December 13, 2022Inventors: Félix Latourte, Qiwei Shi, François Hild, Stéphane Roux
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Patent number: 11497818Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.Type: GrantFiled: May 23, 2018Date of Patent: November 15, 2022Assignees: NANOH, UNIVERSITE LYON 1 CLAUDE BERNARD, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYONInventors: François Lux, Olivier Tillement, Maxime Saint Jean, Pierre Mowat, Pascal Perriat, Stéphane Roux, Anna Mignot
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Publication number: 20220257801Abstract: A particulate structure that includes a/ a biodegradable polymer particle, b/ gold nanoparticles covered on their surface with macrocyclic chelators complexing at least one ion of interest and/or a radionuclide for medical imaging, c/ a polycation having a positive charge over a pH range from 5 to 11, the gold nanoparticles b/ being encapsulated in the polymer particle a/ and/or adsorbed at the surface of the polymer particle a/. Also, a method for preparing the particulate structures. Further, the use of the particulate structures for radiotherapy or chemotherapy in the context of cancer treatment.Type: ApplicationFiled: July 23, 2020Publication date: August 18, 2022Applicant: UNIVERSITE DE FRANCHE COMTEInventors: Gautier LAURENT, Arnaud BEDUNEAU, Stéphane ROUX
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Publication number: 20220241796Abstract: The concrete sludge recycling and recovering method comprises a concrete sludge treatment step consisting in separating aggregates, contained in the concrete sludge, from the water loaded with laitance contained in the concrete sludge; a clarification and dewatering step consisting in clarifying the water loaded with laitance which has been separated during the concrete sludge treatment step and dewatering the laitance contained in the water loaded with laitance; a first use step consisting in using the separated aggregates as raw material for concrete manufacturing; and a second use step consisting in using at least part of the clarified water resulting from the clarification and dewatering step as a raw material for concrete manufacturing.Type: ApplicationFiled: April 22, 2020Publication date: August 4, 2022Inventors: Olivier TOSONI, Hervé GUILLEMIN, Rémi DEL MEDICO, Stéphane ROUX, David LETELLIER
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Patent number: 11215446Abstract: A computer-implemented method for identifying mechanical parameters of an object subjected to mechanical stress is provided. The method comprises a step of acquiring, by an imaging means, images of the object taken before and during the application of the mechanical stress, three steps of calculating the effects due to the stress carried out either on the basis of the modeling of the recorded images or on the basis of a theoretical mechanical modeling of the stress, a step of defining a functional equal to the difference between the two models and a last step of minimizing said functional so that the experimental model is as close as possible to the theoretical mechanical model. Additional measurements make it possible to refine the method.Type: GrantFiled: February 28, 2018Date of Patent: January 4, 2022Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE CACHANInventors: François Hild, Hugo Leclerc, Stéphane Roux
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Patent number: 10987435Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.Type: GrantFiled: August 15, 2017Date of Patent: April 27, 2021Assignees: INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, NANOHInventors: François Lux, Olivier Tillement, Maxime Saint Jean, Pierre Mowat, Pascal Perriat, Stéphane Roux, Anna Mignot
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Publication number: 20210003389Abstract: A computer-implemented method for identifying mechanical parameters of an object subjected to mechanical stress is provided. The method comprises a step of acquiring, by an imaging means, images of the object taken before and during the application of the mechanical stress, three steps of calculating the effects due to the stress carried out either on the basis of the modeling of the recorded images or on the basis of a theoretical mechanical modeling of the stress, a step of defining a functional equal to the difference between the two models and a last step of minimizing said functional so that the experimental model is as close as possible to the theoretical mechanical model. Additional measurements make it possible to refine the method.Type: ApplicationFiled: February 28, 2018Publication date: January 7, 2021Inventors: François HILD, Hugo LECLERC, Stéphane ROUX
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Publication number: 20200349690Abstract: The invention relates to a method for processing images obtained by a diffraction detector, of a crystalline or polycrystalline material, in which a first image of the material is acquired in a state of reference as well as a second image of the material in a deformed state. The invention is characterised in that, in a calculator, during a first step (E6, E12), a current elastic deformation gradient tensor Fe is given a value determined by calculation, during a second step (E7), the current displacement field induced by the tensor Fe is calculated, during a third step (E8), third digital values of a deformed image {hacek over (g)}(x)=g(x+u(x)) corrected by the current displacement field are calculated, and during an iterative algorithm, iterations of the second and third steps (E12, E7, E8) are carried out on modified values of the tensor r Fe until a convergence criterion is met in relation to the correction to the current value of Fe.Type: ApplicationFiled: December 7, 2018Publication date: November 5, 2020Applicants: Electricite de France, Centre National de la Recherche Scientifique (CNRS), Ecole Normale Superieure De CachanInventors: Félix Latourte, Qiwei Shi, François Hild, Stéphane Roux
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Patent number: 10739281Abstract: A tomography scanner includes at least one first emission source (GX1), one first matrix detector (D1), and a computer (C) arranged to produce an initial tomography of an object (E) based on radiographs arising from the first matrix detector, taken from various angles. The tomography scanner further includes a second emission source (GX2) and a second matrix detector (D2) arranged so that, when the object is subjected to a loading that is known at a given instant in time, the computer determines the changes in the object subjected to said loading based only on the information from the first radiograph of the object under loading arising from the first matrix detector, from the second radiograph of the object under loading arising from the second matrix detector and the initial tomograph, the first radiograph and the second radiograph being taken simultaneously at the same given instant in time.Type: GrantFiled: June 1, 2015Date of Patent: August 11, 2020Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE CACHANInventors: François Hild, Hugo Leclerc, Stéphane Roux
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Publication number: 20180264145Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.Type: ApplicationFiled: May 23, 2018Publication date: September 20, 2018Applicants: NANOH, UNIVERSITE LYON 1 CLAUDE BERNARD, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYONInventors: François LUX, Olivier TILLEMENT, Maxime SAINT JEAN, Pierre MOWAT, Pascal PERRIAT, Stéphane ROUX, Anna MIGNOT
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Publication number: 20180008729Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.Type: ApplicationFiled: August 15, 2017Publication date: January 11, 2018Inventors: François LUX, Olivier TILLEMENT, Maxime SAINT JEAN, Pierre MOWAT, Pascal PERRIAT, Stéphane ROUX, Anna MIGNOT